HMRbase accession number | 22956 |
Swiss-prot Accession number | O02671 (Sequence in FASTA format) |
Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: CD_antigen=CD295;Precursor |
Source organism | Sus scrofa (Pig) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
Subcellular location | Membrane; Single-pass type I membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. |
Tissue Specificity | Kidney, liver, spleen, lung, brain, testis, uterus, ovary, corpus luteum, theca and granulosa cells. |
Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation (By similarity). |
Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3 (By similarity). Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). |
Protein Length | 1165 Amino acids |
Molecular weight | 132523 |
Domain Name | fn3 Lep_receptor_Ig |
References | 1 PubMed abstract 10911396 2 PubMed abstract 9800339 3 PubMed abstract 9069130
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Hormone | Q29406 Detail in HMRbase
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Gene ID | 396836 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | |