Hormones are the chemical messengers of the body which convey the message from one part to another. They are secreted from a particular cell/tissue and act on some distantly located cell/tissue. On the basis of chemical composition, there are two types of hormones: (a) Peptides (b) Non-peptides. The action of both types of hormone is mediated through Receptors which receive the signal and relay it to the destination. Receptors of polypeptide/protein hormones are located in the plasma membrane and regulate various intracellular functions by changing the activity of a particular enzyme. Most of the non-peptide hormones interact with intracellular receptors located in cytoplasm or nucleus and this complex provides the signal.
HMRbase is a manually curated database of Hormones and their Receptors. It is a compilation of sequence data after extensive manual literature search and from publicly available databases. HMRbase can be searched on the basis of a variety of data types such as hormone and receptor description and their names, molecular weight, molecular formula, IUPAC name, smiles, physiochemical properties, post-translational modification, developmental stage, subcellular location, length of the protein sequence, organism name etc. This database has been developed by Dr. GPS Raghava's group at Indraprastha Institute of Information Technology, New Delhi, INDIA.
Citation: If you are using this database, please cite:-
Rashid M, Singla D, Sharma A, Kumar M and Raghava GPS (2009): Hmrbase: a database of hormones and their receptors. BMC Genomics 10(1): 307.