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PXXXVVXX details |
| Primary information | |
|---|---|
| ID | antitb_1890, |
| Name | 20483615 |
| N-Terminal modification | Trichoderin B |
| C-Terminal Modification | PXXXVVXX |
| Chemical Modification | Addition of MDA (2-methyl decanoic acid) |
| Linear/Cyclic | Addition of AMAE (2-[(20-aminopropyl) methylamino] ethanol) |
| Length | Addition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8 |
| Chirality | Cyclic |
| Nature | 8 |
| Source | D |
| Species | Natural |
| Strain | Isolated from Trichoderma species 05FI48 |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis M341 |
| Cell Line | MIC = 0.63 μg/mL |
| Inhibition Concentration | In vitro |
| Sequence | 2010 |
| Cytotoxicity | NA |
| In vivo Model | Tratment with this concentration inhibit 100% bacterial growth |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | Lipid bilayer |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1891, |
| Name | 20483615 |
| N-Terminal modification | Trichoderin B |
| C-Terminal Modification | PXXXVVXX |
| Chemical Modification | Addition of MDA (2-methyl decanoic acid) |
| Linear/Cyclic | Addition of AMAE (2-[(20-aminopropyl) methylamino] ethanol) |
| Length | Addition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8 |
| Chirality | Cyclic |
| Nature | 8 |
| Source | D |
| Species | Natural |
| Strain | Isolated from Trichoderma species 05FI48 |
| Inhibition Concentration | Mycobacterium bovis |
| In Vitro/ In vivo | Mycobacterium bovis BCG |
| Cell Line | MIC = 0.02 μg/ml |
| Inhibition Concentration | In vitro |
| Sequence | 2010 |
| Cytotoxicity | NA |
| In vivo Model | Tratment with this concentration inhibit 100% bacterial growth |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | Lipid bilayer |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1892, |
| Name | 20483615 |
| N-Terminal modification | Trichoderin B |
| C-Terminal Modification | PXXXVVXX |
| Chemical Modification | Addition of MDA (2-methyl decanoic acid) |
| Linear/Cyclic | Addition of AMAE (2-[(20-aminopropyl) methylamino] ethanol) |
| Length | Addition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8 |
| Chirality | Cyclic |
| Nature | 8 |
| Source | D |
| Species | Natural |
| Strain | Isolated from Trichoderma species 05FI48 |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37RV |
| Cell Line | MIC = 0.63 μg/ml |
| Inhibition Concentration | In vitro |
| Sequence | 2010 |
| Cytotoxicity | NA |
| In vivo Model | Tratment with this concentration inhibit 100% bacterial growth |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | Lipid bilayer |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |