Primary information |
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ID | antitb_1892 |
Peptide Name | Trichoderin B |
Sequence | PXXXVVXX |
N-terminal Modification | Addition of MDA (2-methyl decanoic acid) |
C-terminal Modification | Addition of AMAE (2-[(20-aminopropyl) methylamino] ethanol) |
Chemical Modification | Addition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8 |
Linear/ Cyclic | Cyclic |
Length | 8 |
Chirality | D |
Nature | NA |
Source | Natural |
Origin | Isolated from Trichoderma species 05FI48 |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37RV |
Inhibition Concentartion | MIC = 0.63 μg/ml |
In vitro/In vivo | In vitro |
Cell Line | NA |
Inhibition Concentartion | Tratment with this concentration inhibit 100% bacterial growth |
Cytotoxicity | NA |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | NA |
Target | Lipid bilayer |
Combination Therapy | NA |
Other Activities | NA |
Pubmed ID | 20483615 |
Year of Publication | 2010 |
3-D Structure | NA |