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FISQIISTAI details |
| Primary information | |
|---|---|
| ID | antitb_1988, |
| Name | 25561178 |
| N-Terminal modification | Teixobactin |
| C-Terminal Modification | FISQIISTAI |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | adenylation, C, condensation; MT, methylation (of phenylalanine); T, thiolation (carrier); and TE,thioesterase (Ile-Thr ring closure). NmPhe,N-methylated phenylalanin |
| Chirality | Cyclic |
| Nature | 10 |
| Source | D |
| Origin | Cationic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
| Cell Line | MIC= 0.125µg/ml |
| Inhibition Concentration | In vitro |
| Sequence | 2015 |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Binding of teixobactin to WTA precursor contributes to efficient lysis and killing, due to digestion of the cell wall by liberated autolysins |
| Other activities | Cell wall |
| PMID | NA |
| Year of Publication | S. aureus (MSSA), S. aureus 110% serum, S. aureus (MRSA), Enterococcus faecalis (VRE), Enterococcus faecium (VRE), Streptococcus pneumoniae (penicillinR), Streptococcus pyogenes, Streptococcus agalactiae, Viridans group streptococci, B. anthracis, Clostridium difficile, Propionibacterium acnes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Escherichia coli (asmB1), Pseudomonas aeruginosa, Klebsiella pneumoniae |
| Tertiary Structure (Technique) | Not Predicted), |