Detailed description page of AntiTbPdb
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antitb_1988 details |
| Primary information | |
|---|---|
| ID | antitb_1988 |
| Peptide Name | Teixobactin |
| Sequence | FISQIISTAI |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | adenylation, C, condensation; MT, methylation (of phenylalanine); T, thiolation (carrier); and TE,thioesterase (Ile-Thr ring closure). NmPhe,N-methylated phenylalanin |
| Linear/ Cyclic | Cyclic |
| Length | 10 |
| Chirality | D |
| Nature | Cationic |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis H37Rv |
| Inhibition Concentartion | MIC= 0.125µg/ml |
| In vitro/In vivo | In vitro |
| Cell Line | NA |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Binding of teixobactin to WTA precursor contributes to efficient lysis and killing, due to digestion of the cell wall by liberated autolysins |
| Target | Cell wall |
| Combination Therapy | NA |
| Other Activities | S. aureus (MSSA), S. aureus 110% serum, S. aureus (MRSA), Enterococcus faecalis (VRE), Enterococcus faecium (VRE), Streptococcus pneumoniae (penicillinR), Streptococcus pyogenes, Streptococcus agalactiae, Viridans group streptococci, B. anthracis, Clostridium difficile, Propionibacterium acnes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Escherichia coli (asmB1), Pseudomonas aeruginosa, Klebsiella pneumoniae |
| Pubmed ID | 25561178 |
| Year of Publication | 2015 |
| 3-D Structure | NA |