AHTpin: Designing of Antihypetensive peptides

Trieptide Matrices page of AHTpin

Antihypertensive Acivity of Tripeptides
This page provides antihypertensive activity of all possible tripeptides (20 × 20 × 20 = 8000). Experimentally validated tripeptides' antihypertensive activity (pIC₅₀) is shown by black color. For rest of the tripeptieds, we computed antihypertensive activity (pIC₅₀) using one of the features given below (amino acid composition, atomic composition, Descriptors) which are presented by blue color. User needs to select first residue of tripeptides, rest of the residues (2nd and 3rd residues) are presented by a matrix of dimension 20 × 20. User may select desired model for prediction.
Amino Acid Composition	Atomic Composition	Descriptor

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon AACom

Select the Initial Alphabet of Tripeptide for which Prediction Matrix to be displayed
A	C	D	E	F	G	H	I	K	L
M	N	P	Q	R	S	T	V	W	Y

Tripeptide starting with letter A (This is the First position of Tripeptide^***)

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	5.14	5.17	5.00	4.41	4.73	3.62	4.03	4.55	5.11	4.99	5.19	4.03	4.52	4.34	5.32	4.52	5.20	4.59	4.99	5.06
C	5.17	5.38	5.26	4.80	4.97	4.24	4.28	4.99	5.08	5.24	5.41	4.28	4.94	4.73	5.36	5.03	5.18	4.94	5.29	5.19
D	5.00	5.26	5.04	4.62	4.92	3.92	4.10	4.82	4.90	5.06	5.23	4.10	4.77	4.56	5.18	4.86	5.00	4.91	5.12	4.87
E	4.41	4.80	4.62	4.11	4.44	3.73	3.63	4.36	4.30	4.24	4.76	3.63	4.58	4.09	4.72	4.39	4.54	4.43	4.51	4.41
F	4.73	4.97	4.92	4.44	4.43	3.60	3.56	4.47	4.47	4.20	4.88	3.80	3.21	4.25	4.98	4.68	4.52	4.35	4.94	4.74
G	3.62	4.24	3.92	3.73	3.60	3.58	3.15	3.65	3.93	4.32	4.23	3.07	3.25	3.42	4.07	3.28	4.11	3.74	3.72	3.77
H	4.03	4.28	4.10	3.63	3.56	3.15	3.33	3.83	3.92	4.36	4.24	3.12	3.64	3.46	3.97	3.85	3.98	3.78	4.27	4.03
I	4.55	4.99	4.82	4.36	4.47	3.65	3.83	4.22	4.70	4.65	4.96	3.71	3.46	4.63	5.09	4.59	4.76	4.55	5.17	4.66
K	5.11	5.08	4.90	4.30	4.47	3.93	3.92	4.70	5.51	4.73	5.13	4.10	4.37	4.23	4.78	4.68	4.96	4.37	5.02	4.79
L	4.99	5.24	5.06	4.44	4.67	4.32	4.36	4.65	4.73	4.83	5.21	4.11	3.62	4.44	5.20	5.01	4.84	4.71	4.81	5.31
M	5.19	5.41	5.23	4.76	4.88	4.23	4.24	4.96	5.13	5.21	5.32	4.24	4.83	4.70	5.33	5.00	5.15	4.77	5.31	5.24
N	4.03	4.28	4.10	3.63	3.80	3.07	3.12	3.71	4.10	4.11	4.24	3.09	3.73	3.45	4.20	3.87	3.87	3.92	4.27	3.94
P	4.57	4.94	4.77	4.58	4.49	4.04	3.64	4.50	4.37	4.86	4.83	3.73	5.34	4.48	5.04	4.39	4.82	4.64	4.66	4.32
Q	4.34	4.73	4.56	4.09	4.25	3.42	3.46	4.63	2.74	4.44	4.70	3.45	4.48	3.75	4.51	4.33	4.47	4.24	4.68	4.89
R	5.32	5.36	5.18	4.72	5.52	4.07	3.97	5.09	4.78	5.20	5.33	4.20	5.04	4.51	4.95	4.95	5.10	4.72	5.59	5.11
S	4.52	5.03	4.86	4.39	4.68	3.80	3.85	4.59	4.68	5.01	5.00	3.87	3.62	4.33	4.95	4.58	4.77	4.67	4.75	4.93
T	5.20	5.18	5.00	4.54	5.02	4.11	3.98	4.76	4.96	4.84	5.15	3.87	4.82	4.47	5.10	4.77	4.78	4.68	4.89	4.93
V	4.59	4.94	4.91	4.43	2.67	3.74	3.78	4.55	4.37	4.71	4.77	3.92	3.47	4.24	4.72	4.67	4.68	4.18	4.79	4.81
W	4.99	5.29	5.12	4.51	4.94	3.72	4.27	5.17	5.02	4.81	5.31	4.27	4.66	4.68	5.59	4.75	4.89	4.79	5.19	4.99
Y	5.06	5.19	4.87	4.41	4.74	3.77	4.03	4.66	4.79	5.31	5.24	3.94	4.32	4.89	5.11	4.93	4.93	4.81	4.99	4.82

^**Scores in BLUE are predicted ones and in BLACK are actual ones.

^***In this matrix, vertical header represents second position and horizontal header denotes third position of Amino acid in tripeptides e.g. a tripeptide AHT would be having pIC50 value of 3.73 (precidted).

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon AtomicCom

Select the Initial Alphabet of Tripeptide for which Prediction Matrix to be displayed
A	C	D	E	F	G	H	I	K	L
M	N	P	Q	R	S	T	V	W	Y

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	4.34	4.25	4.18	4.97	4.33	3.65	3.92	3.65	4.73	4.32	5.03	3.54	4.52	3.07	4.86	3.49	4.77	4.42	4.66	4.26
C	4.18	4.18	4.13	4.84	4.35	3.73	3.87	3.81	4.41	4.36	4.72	3.49	4.47	3.17	4.24	3.68	4.38	4.44	4.29	4.23
D	4.10	4.13	4.02	4.76	4.63	3.61	3.80	3.74	4.34	4.38	4.65	3.42	4.45	3.10	4.22	3.60	4.31	4.50	4.21	3.66
E	4.73	4.67	4.59	5.24	5.14	4.30	4.33	4.05	3.97	4.24	5.17	3.95	5.63	3.63	4.75	4.14	4.83	4.90	3.75	3.98
F	3.99	4.09	4.40	5.07	4.10	3.39	2.87	4.03	3.63	4.20	4.53	3.46	3.21	3.32	4.84	3.84	3.60	3.89	4.69	4.27
G	3.76	3.91	3.80	4.64	3.87	3.51	3.60	3.29	4.18	4.37	4.40	3.19	3.25	2.80	3.77	3.28	4.23	4.16	3.47	3.78
H	3.63	3.66	3.58	4.29	2.93	3.21	4.02	3.34	3.87	4.14	4.17	2.94	3.56	2.65	3.39	3.18	3.44	3.90	4.43	3.68
I	3.36	3.61	3.53	4.01	4.10	2.85	3.35	2.77	4.33	3.43	4.12	2.90	3.46	3.55	3.96	3.08	3.77	3.92	4.63	3.76
K	5.06	4.78	4.70	4.48	4.24	4.37	4.44	4.90	5.51	4.25	5.16	4.80	4.54	3.02	4.61	4.26	5.55	4.32	5.64	4.74
L	4.32	4.45	4.47	4.37	4.44	4.32	4.43	3.70	3.96	4.10	4.95	3.30	3.62	3.84	4.91	4.38	3.85	4.51	4.32	4.80
M	4.87	4.62	4.54	5.24	4.69	4.11	4.28	4.22	4.69	4.77	5.09	3.82	4.82	3.58	4.91	4.09	4.78	4.12	4.83	4.88
N	3.47	3.49	3.42	4.13	3.72	3.01	3.16	3.11	4.40	3.25	3.93	2.75	3.65	2.43	3.60	2.97	3.35	4.18	3.81	3.42
P	4.08	4.23	4.21	5.56	4.15	3.86	3.54	4.02	3.93	4.23	4.68	3.39	5.34	3.50	5.03	3.44	4.43	4.49	4.35	4.20
Q	3.16	3.35	3.27	3.98	3.75	2.78	3.03	3.90	2.74	3.92	3.86	2.59	3.92	1.88	2.43	2.82	3.52	3.59	4.00	4.17
R	5.14	4.53	4.52	5.21	5.52	3.84	3.89	4.47	4.53	5.11	5.32	3.89	5.61	2.53	2.95	4.07	4.76	4.48	6.04	4.87
S	3.58	3.84	3.77	4.47	4.24	3.36	3.55	3.45	4.05	4.41	4.36	3.12	3.62	2.81	3.94	3.27	4.01	4.37	3.72	4.30
T	4.92	4.59	4.52	5.22	5.02	4.28	3.88	4.20	5.36	4.01	5.10	3.55	4.88	3.56	4.67	4.06	4.60	4.83	4.33	4.54
V	4.10	4.20	4.26	4.82	2.67	3.73	3.86	3.89	3.72	4.19	3.98	3.94	3.47	3.17	3.95	3.97	4.36	4.18	4.51	4.28
W	4.57	4.23	4.16	3.81	4.90	3.12	4.62	4.80	5.22	4.15	4.88	3.77	4.53	3.80	5.71	3.47	4.05	4.72	5.19	4.27
Y	3.39	3.43	2.82	3.33	3.74	2.74	3.10	3.15	3.58	3.92	4.19	2.61	3.64	3.23	3.80	3.38	3.52	3.72	3.53	3.76

^**Scores in BLUE are predicted ones and in BLACK are actual ones.

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon Descriptors

Select the Initial Alphabet of Tripeptide for which Prediction Matrix to be displayed
A	C	D	E	F	G	H	I	K	L
M	N	P	Q	R	S	T	V	W	Y

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	4.07	4.07	4.07	4.23	5.14	4.07	5.14	4.41	4.07	4.41	4.34	3.61	4.52	4.07	4.07	3.46	3.26	4.08	5.14	5.14
C	4.07	4.08	4.07	4.23	5.14	4.07	5.14	4.41	4.08	4.41	4.34	3.61	4.36	4.07	4.07	3.46	3.26	4.08	5.14	5.14
D	4.14	4.14	4.14	4.29	5.14	4.14	5.14	4.47	4.14	4.47	4.41	3.67	4.42	4.14	4.14	3.52	3.33	4.14	5.14	5.14
E	4.23	4.23	4.23	4.23	5.14	4.23	5.14	4.56	4.23	4.24	4.50	3.77	4.52	4.23	4.23	3.61	3.42	4.23	5.14	5.14
F	3.72	3.72	3.72	3.88	5.14	3.72	5.14	4.06	3.72	4.20	3.99	3.26	3.21	3.72	3.72	3.11	2.91	3.72	5.14	5.14
G	4.07	4.07	4.07	4.23	3.72	3.97	3.60	4.40	4.07	4.40	4.34	3.61	3.25	4.07	4.07	3.28	3.26	4.07	4.23	3.67
H	3.60	3.60	3.60	3.76	5.14	3.60	5.14	3.94	3.61	3.94	3.87	3.60	3.89	3.60	3.09	2.99	2.80	3.61	5.14	5.14
I	4.41	4.41	4.40	4.56	4.98	4.40	4.60	4.41	4.41	4.41	4.34	3.94	3.46	4.40	4.40	3.79	3.59	4.41	5.14	5.14
K	4.07	4.08	4.07	4.23	5.14	4.07	5.14	4.41	5.51	4.41	4.34	3.61	4.36	4.07	4.07	3.46	3.26	4.08	5.14	5.14
L	4.41	4.41	4.40	4.56	5.14	4.40	5.14	4.41	4.41	4.41	4.34	3.94	3.62	4.40	4.40	3.79	3.59	4.41	5.14	5.14
M	4.34	4.34	4.34	4.50	5.14	4.34	5.14	4.34	4.34	4.34	4.34	3.88	4.63	4.34	4.34	3.72	3.53	4.34	5.14	5.14
N	3.61	3.61	3.61	3.77	5.14	3.61	5.14	3.94	3.61	3.94	3.88	3.61	3.89	3.61	3.61	2.99	2.80	3.61	5.14	5.14
P	4.57	4.57	4.57	4.73	5.14	4.57	5.14	4.90	4.57	4.90	4.83	4.10	5.34	4.57	4.57	3.95	3.75	4.57	5.14	5.14
Q	4.07	4.07	4.07	4.23	5.14	4.07	5.14	4.40	2.74	4.40	4.34	3.61	4.36	4.07	4.07	3.46	3.26	4.07	5.14	5.14
R	4.84	4.84	4.84	5.00	5.52	4.84	4.63	5.17	4.84	5.17	5.11	4.37	5.13	4.84	4.33	4.22	4.03	4.84	5.14	5.14
S	4.07	4.07	3.67	4.23	5.14	4.07	5.14	4.40	4.07	4.40	4.34	3.21	3.62	4.07	4.07	3.45	3.26	4.07	5.14	5.14
T	3.88	3.88	3.48	4.03	5.02	3.88	3.68	4.21	3.88	4.21	4.15	3.02	4.44	3.88	3.88	3.26	3.07	3.88	5.14	5.14
V	4.08	4.08	4.07	4.23	2.67	4.07	5.14	4.41	4.08	4.41	4.34	3.61	3.47	4.07	4.07	3.46	3.26	4.18	5.14	5.14
W	4.23	4.23	4.23	4.23	5.14	4.23	5.14	4.56	4.23	4.56	4.50	3.76	4.52	4.23	4.23	3.61	3.42	4.23	5.19	5.14
Y	3.67	3.67	3.67	3.83	5.14	3.67	5.14	4.00	3.67	4.00	3.94	3.21	3.96	3.67	3.67	3.06	2.86	3.67	5.14	5.14

^**Scores in BLUE are predicted ones and in BLACK are actual ones.

AHTpin

Antihypertensive Peptide Inhibitors

Antihypertensive Acivity of Tripeptides

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC50 (AHTPs) Based upon AACom

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC50 (AHTPs) Based upon AtomicCom

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC50 (AHTPs) Based upon Descriptors

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon AACom

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon AtomicCom

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC₅₀ (AHTPs) Based upon Descriptors