AHTpin: Designing of Antihypetensive peptides

AHTpin

Antihypertensive Peptide Inhibitors


*** Reference: Kumar et. al. (2015) An in silico platform for predicting, screening and designing of antihypertensive peptides. Sci. Rep. 5, 12512.
Trieptide Matrices page of AHTpin

Antihypertensive Acivity of Tripeptides

This page provides antihypertensive activity of all possible tripeptides (20 × 20 × 20 = 8000). Experimentally validated tripeptides' antihypertensive activity (pIC50) is shown by black color. For rest of the tripeptieds, we computed antihypertensive activity (pIC50) using one of the features given below (amino acid composition, atomic composition, Descriptors) which are presented by blue color. User needs to select first residue of tripeptides, rest of the residues (2nd and 3rd residues) are presented by a matrix of dimension 20 × 20. User may select desired model for prediction.
Amino Acid Composition          Atomic Composition       Descriptor       

[A-Y] x 20 x 20 Matrix representing Dipeptides pIC50 (AHTPs) Based upon AACom


Select the Initial Alphabet of Tripeptide for which Prediction Matrix to be displayed
A C D E F G H I K L
M N P Q R S T V W Y
        
Tripeptide starting with letter A (This is the First position of Tripeptide***)
ACDEFGHIKLMNPQRSTVWY
A5.14 5.17 5.00 4.41 4.73 3.62 4.03 4.55 5.11 4.99 5.19 4.03 4.52 4.34 5.32 4.52 5.20 4.59 4.99 5.06
C5.17 5.38 5.26 4.80 4.97 4.24 4.28 4.99 5.08 5.24 5.41 4.28 4.94 4.73 5.36 5.03 5.18 4.94 5.29 5.19
D5.00 5.26 5.04 4.62 4.92 3.92 4.10 4.82 4.90 5.06 5.23 4.10 4.77 4.56 5.18 4.86 5.00 4.91 5.12 4.87
E4.41 4.80 4.62 4.11 4.44 3.73 3.63 4.36 4.30 4.24 4.76 3.63 4.58 4.09 4.72 4.39 4.54 4.43 4.51 4.41
F4.73 4.97 4.92 4.44 4.43 3.60 3.56 4.47 4.47 4.20 4.88 3.80 3.21 4.25 4.98 4.68 4.52 4.35 4.94 4.74
G3.62 4.24 3.92 3.73 3.60 3.58 3.15 3.65 3.93 4.32 4.23 3.07 3.25 3.42 4.07 3.28 4.11 3.74 3.72 3.77
H4.03 4.28 4.10 3.63 3.56 3.15 3.33 3.83 3.92 4.36 4.24 3.12 3.64 3.46 3.97 3.85 3.98 3.78 4.27 4.03
I4.55 4.99 4.82 4.36 4.47 3.65 3.83 4.22 4.70 4.65 4.96 3.71 3.46 4.63 5.09 4.59 4.76 4.55 5.17 4.66
K5.11 5.08 4.90 4.30 4.47 3.93 3.92 4.70 5.51 4.73 5.13 4.10 4.37 4.23 4.78 4.68 4.96 4.37 5.02 4.79
L4.99 5.24 5.06 4.44 4.67 4.32 4.36 4.65 4.73 4.83 5.21 4.11 3.62 4.44 5.20 5.01 4.84 4.71 4.81 5.31
M5.19 5.41 5.23 4.76 4.88 4.23 4.24 4.96 5.13 5.21 5.32 4.24 4.83 4.70 5.33 5.00 5.15 4.77 5.31 5.24
N4.03 4.28 4.10 3.63 3.80 3.07 3.12 3.71 4.10 4.11 4.24 3.09 3.73 3.45 4.20 3.87 3.87 3.92 4.27 3.94
P4.57 4.94 4.77 4.58 4.49 4.04 3.64 4.50 4.37 4.86 4.83 3.73 5.34 4.48 5.04 4.39 4.82 4.64 4.66 4.32
Q4.34 4.73 4.56 4.09 4.25 3.42 3.46 4.63 2.74 4.44 4.70 3.45 4.48 3.75 4.51 4.33 4.47 4.24 4.68 4.89
R5.32 5.36 5.18 4.72 5.52 4.07 3.97 5.09 4.78 5.20 5.33 4.20 5.04 4.51 4.95 4.95 5.10 4.72 5.59 5.11
S4.52 5.03 4.86 4.39 4.68 3.80 3.85 4.59 4.68 5.01 5.00 3.87 3.62 4.33 4.95 4.58 4.77 4.67 4.75 4.93
T5.20 5.18 5.00 4.54 5.02 4.11 3.98 4.76 4.96 4.84 5.15 3.87 4.82 4.47 5.10 4.77 4.78 4.68 4.89 4.93
V4.59 4.94 4.91 4.43 2.67 3.74 3.78 4.55 4.37 4.71 4.77 3.92 3.47 4.24 4.72 4.67 4.68 4.18 4.79 4.81
W4.99 5.29 5.12 4.51 4.94 3.72 4.27 5.17 5.02 4.81 5.31 4.27 4.66 4.68 5.59 4.75 4.89 4.79 5.19 4.99
Y5.06 5.19 4.87 4.41 4.74 3.77 4.03 4.66 4.79 5.31 5.24 3.94 4.32 4.89 5.11 4.93 4.93 4.81 4.99 4.82

**Scores in BLUE are predicted ones and in BLACK are actual ones.

***In this matrix, vertical header represents second position and horizontal header denotes third position of Amino acid in tripeptides e.g. a tripeptide AHT would be having pIC50 value of 3.73 (precidted).