AHTpin: Designing of Antihypetensive peptides

AHTpin

Antihypertensive Peptide Inhibitors


*** Reference: Kumar et. al. (2015) An in silico platform for predicting, screening and designing of antihypertensive peptides. Sci. Rep. 5, 12512.

Scanning AHT (Hexa Peptide) in a Protein

User(s) can submit protein sequence (in single letter code) to generate all possible peptide fragments of length 6 residues (with predicted antihypertensive ability and physicochemical properties). Mutants of the generated peptide fragments may be generated to design best putative antihypertensive peptide. Graphical display of results is an interesting feature to estimate putative antihypertensive peptides present in whole protein.


(A) Paste Protein sequence (Please paste amino acid sequence in single letter code):      

(B) SVM threshold:

(C) Select model: AMINO ACID COMPOSITION   ATOMIC COMPOSITION  


(D) Physicochemical property:


Hydrophobicity    Sterichinderance    Solvation   Hydropathicity    Amphipathicity    Hydrophilicity   
Net Hydrogen    Charge pI Molecular weight All


  (E) Show Results:

Tabular    Graphically