AHTpin

Antihypertensive Peptide Inhibitors

• Dipeptide
  • AHT Activity
• Tripeptide
  • AHT Activity
• Tetrapeptide
  • Design peptide
  • Batch submission
  • Protein scan
• Pentapeptide
  • Design peptide
  • Batch submission
  • Protein scan
• Hexapeptide
  • Design peptide
  • Batch submission
  • Protein scan
• 7-12 residues
  • Design peptide
  • Batch submission
  • Protein scan
• 13 residues and above
  • Design peptide
  • Batch submission
  • Protein scan
• AllinOne
  • Variable Length I/P
• Propensity Matrices
  • P. Matrices

This module of AHTpin allows user to design antihypertensive peptides of length above 12 residues residues. This module generates all possible mutations in a query peptide submitted by the user. All possible mutants are generated (through amino acid substitution at single position at a time) to get the optimized antihypertensive tetrapeptide. It predicts whether peptide or its mutants are having antihypertensive property or not. User can select the physicochemical properties (viz. hydrophobicity, charge, hydrophilicity etc.) to be displayed as an additional information. For more information, please visit HELP page.

(A) Paste peptide sequence (amino acids single leter code) :

(B) Select model: AMINO ACID COMPOSITION   ATOMIC COMPOSITION

(C) SVM threshold:    -1.0 -0.9 -0.8 -0.7 -0.6 -0.5 -0.4 -0.3 -0.2 -0.1 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 -1.0 -0.9 -0.8 -0.7 -0.6 -0.5 -0.4 -0.3 -0.2 -0.1 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0

(D) Physicochemical property: