AHTpin: Designing of Antihypetensive peptides

AHTpin

Antihypertensive Peptide Inhibitors


*** Reference: Kumar et. al. (2015) An in silico platform for predicting, screening and designing of antihypertensive peptides. Sci. Rep. 5, 12512.
Antihypertensive Activity of Dipeptides

Antihypertensive Activity of Peptides

This page provides antihypertensive activity of all possible dipeptides (20 × 20 = 400). Experimentally validated dipeptides' antihypertensive activity (pIC50) is shown by black color. For rest of the dipeptides, we computed antihypertensive activity (pIC50) using one of the features given below (amino acid composition, atomic composition, Descriptors) and is presented by blue color. User may select desired model for prediction.
Amino Acid Composition :           Atomic Composition :        Descriptor :       

20 x 20 Matrix representing Dipeptides' pIC50 (AHTPs) Based upon AACom


ACDEFGHIKLMNPQRSTVWY
A4.29 3.68 3.54 3.54 3.78 2.60 3.28 5.47 3.61 3.61 3.65 3.68 4.54 3.61 4.02 3.65 3.60 3.10 5.00 4.85
C3.68 3.74 3.61 3.61 5.71 2.98 3.68 3.81 3.68 3.67 3.71 3.74 3.72 3.68 3.75 3.71 3.66 3.78 4.00 4.06
D2.42 3.61 3.47 3.47 3.44 5.67 3.54 3.67 3.29 2.70 3.22 3.61 5.67 3.54 3.61 3.57 3.52 3.64 4.89 3.92
E2.00 3.61 3.47 3.47 3.79 2.00 3.54 3.67 3.54 3.53 3.57 3.61 2.92 3.54 3.18 3.57 3.52 3.64 3.86 5.57
F3.86 3.92 3.79 5.84 4.10 2.43 3.85 3.99 3.58 5.88 3.89 3.92 3.50 3.85 3.04 3.89 3.84 3.96 5.41 5.43
G2.70 2.98 2.04 2.27 3.56 2.14 2.51 2.92 2.27 2.60 2.85 2.98 4.18 2.72 3.79 2.42 2.24 2.34 4.52 4.17
H3.61 3.68 3.54 3.54 3.85 2.20 3.61 3.74 3.61 2.49 3.64 3.68 3.66 3.61 3.68 3.64 3.59 3.71 3.93 4.58
I3.82 3.81 3.67 3.67 4.18 2.92 3.74 3.87 3.74 3.74 3.78 3.81 3.89 3.74 3.82 3.77 3.72 3.84 5.82 5.68
K4.50 3.68 3.54 3.54 4.55 2.49 3.61 3.74 3.61 4.30 3.64 3.68 4.66 3.61 3.42 3.64 3.59 3.71 5.79 5.79
L3.51 3.67 3.53 3.53 3.46 2.06 3.60 3.74 3.60 3.60 3.64 3.67 3.65 3.60 3.68 3.64 3.59 3.71 5.36 5.17
M3.82 3.71 3.57 3.57 6.04 2.32 3.64 3.78 3.64 3.64 3.68 3.71 3.87 3.64 3.72 3.68 3.63 3.75 5.00 3.71
N3.68 3.74 3.61 3.61 4.33 1.92 3.68 3.81 3.09 3.67 3.71 3.74 2.64 3.68 3.75 3.71 3.66 3.78 4.00 4.49
P3.66 3.72 3.59 3.59 3.90 1.77 3.66 3.79 3.66 3.47 3.69 3.72 3.70 3.66 5.39 3.69 3.64 3.76 3.98 4.04
Q3.61 3.68 3.54 3.54 3.85 2.13 3.61 3.74 3.05 3.60 3.64 4.05 4.18 3.61 3.68 3.64 3.59 3.71 3.93 3.99
R3.34 3.75 3.61 3.61 4.03 2.99 3.68 3.82 3.68 3.13 3.72 3.75 4.82 3.68 3.57 4.21 3.67 3.79 4.80 4.98
S3.65 3.71 3.57 3.57 3.89 2.07 3.64 3.77 3.64 3.64 3.68 3.71 3.69 3.64 3.72 3.68 5.39 3.74 3.97 4.18
T3.60 3.66 3.52 3.52 4.74 2.00 3.59 3.72 3.59 3.59 3.63 3.66 3.54 3.59 3.67 3.63 3.58 3.69 3.92 3.98
V3.72 3.78 3.64 3.64 5.04 2.96 3.71 3.84 4.89 4.89 3.75 3.78 3.38 3.71 4.28 3.74 3.69 3.81 5.85 5.15
W3.56 4.00 3.86 3.86 4.18 2.23 5.29 4.07 3.93 4.52 4.02 4.00 3.66 3.93 4.01 3.97 3.20 3.30 4.26 4.42
Y3.34 4.06 3.92 3.92 4.24 2.82 5.29 4.13 3.21 4.09 4.03 4.29 3.14 3.99 4.07 3.39 3.98 4.10 5.09 4.38

**Values in BLUE are predicted ones and in BLACK are actual ones.

** In above matrix, vertical header shows first position and horizontal header represents second position of Amino acid in dipeptides e.g. a dipeptide KD would be having pIC50 value of 3.29 (predicted).