AHTpin: Designing of Antihypetensive peptides

Antihypertensive Activity of Dipeptides

Antihypertensive Activity of Peptides
This page provides antihypertensive activity of all possible dipeptides (20 × 20 = 400). Experimentally validated dipeptides' antihypertensive activity (pIC₅₀) is shown by black color. For rest of the dipeptides, we computed antihypertensive activity (pIC₅₀) using one of the features given below (amino acid composition, atomic composition, Descriptors) and is presented by blue color. User may select desired model for prediction.
Amino Acid Composition :	Atomic Composition :	Descriptor :

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon AACom

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	4.29	3.68	3.54	3.54	3.78	2.60	3.28	5.47	3.61	3.61	3.65	3.68	4.54	3.61	4.02	3.65	3.60	3.10	5.00	4.85
C	3.68	3.74	3.61	3.61	5.71	2.98	3.68	3.81	3.68	3.67	3.71	3.74	3.72	3.68	3.75	3.71	3.66	3.78	4.00	4.06
D	2.42	3.61	3.47	3.47	3.44	5.67	3.54	3.67	3.29	2.70	3.22	3.61	5.67	3.54	3.61	3.57	3.52	3.64	4.89	3.92
E	2.00	3.61	3.47	3.47	3.79	2.00	3.54	3.67	3.54	3.53	3.57	3.61	2.92	3.54	3.18	3.57	3.52	3.64	3.86	5.57
F	3.86	3.92	3.79	5.84	4.10	2.43	3.85	3.99	3.58	5.88	3.89	3.92	3.50	3.85	3.04	3.89	3.84	3.96	5.41	5.43
G	2.70	2.98	2.04	2.27	3.56	2.14	2.51	2.92	2.27	2.60	2.85	2.98	4.18	2.72	3.79	2.42	2.24	2.34	4.52	4.17
H	3.61	3.68	3.54	3.54	3.85	2.20	3.61	3.74	3.61	2.49	3.64	3.68	3.66	3.61	3.68	3.64	3.59	3.71	3.93	4.58
I	3.82	3.81	3.67	3.67	4.18	2.92	3.74	3.87	3.74	3.74	3.78	3.81	3.89	3.74	3.82	3.77	3.72	3.84	5.82	5.68
K	4.50	3.68	3.54	3.54	4.55	2.49	3.61	3.74	3.61	4.30	3.64	3.68	4.66	3.61	3.42	3.64	3.59	3.71	5.79	5.79
L	3.51	3.67	3.53	3.53	3.46	2.06	3.60	3.74	3.60	3.60	3.64	3.67	3.65	3.60	3.68	3.64	3.59	3.71	5.36	5.17
M	3.82	3.71	3.57	3.57	6.04	2.32	3.64	3.78	3.64	3.64	3.68	3.71	3.87	3.64	3.72	3.68	3.63	3.75	5.00	3.71
N	3.68	3.74	3.61	3.61	4.33	1.92	3.68	3.81	3.09	3.67	3.71	3.74	2.64	3.68	3.75	3.71	3.66	3.78	4.00	4.49
P	3.66	3.72	3.59	3.59	3.90	1.77	3.66	3.79	3.66	3.47	3.69	3.72	3.70	3.66	5.39	3.69	3.64	3.76	3.98	4.04
Q	3.61	3.68	3.54	3.54	3.85	2.13	3.61	3.74	3.05	3.60	3.64	4.05	4.18	3.61	3.68	3.64	3.59	3.71	3.93	3.99
R	3.34	3.75	3.61	3.61	4.03	2.99	3.68	3.82	3.68	3.13	3.72	3.75	4.82	3.68	3.57	4.21	3.67	3.79	4.80	4.98
S	3.65	3.71	3.57	3.57	3.89	2.07	3.64	3.77	3.64	3.64	3.68	3.71	3.69	3.64	3.72	3.68	5.39	3.74	3.97	4.18
T	3.60	3.66	3.52	3.52	4.74	2.00	3.59	3.72	3.59	3.59	3.63	3.66	3.54	3.59	3.67	3.63	3.58	3.69	3.92	3.98
V	3.72	3.78	3.64	3.64	5.04	2.96	3.71	3.84	4.89	4.89	3.75	3.78	3.38	3.71	4.28	3.74	3.69	3.81	5.85	5.15
W	3.56	4.00	3.86	3.86	4.18	2.23	5.29	4.07	3.93	4.52	4.02	4.00	3.66	3.93	4.01	3.97	3.20	3.30	4.26	4.42
Y	3.34	4.06	3.92	3.92	4.24	2.82	5.29	4.13	3.21	4.09	4.03	4.29	3.14	3.99	4.07	3.39	3.98	4.10	5.09	4.38

^**Values in BLUE are predicted ones and in BLACK are actual ones.

^** In above matrix, vertical header shows first position and horizontal header represents second position of Amino acid in dipeptides e.g. a dipeptide KD would be having pIC50 value of 3.29 (predicted).

/usr1/webserver/cgibin/ahtpin/data/ditrimatrix

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon Descriptors

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	4.29	2.78	2.40	2.66	3.78	2.60	3.28	5.47	3.03	3.14	3.15	2.64	4.54	2.91	4.02	2.37	2.82	3.10	5.00	4.85
C	2.93	3.20	2.89	3.11	5.71	2.15	4.15	3.65	3.49	3.62	3.59	3.12	3.20	3.36	4.48	3.02	3.44	3.49	4.89	4.48
D	2.42	2.46	2.09	2.34	3.44	5.67	3.38	2.88	3.29	2.70	3.22	2.34	5.67	2.60	4.01	2.08	2.51	2.72	4.89	3.74
E	2.00	2.54	2.20	2.43	3.67	2.00	3.48	2.99	2.82	2.95	2.92	2.44	2.92	2.69	3.18	2.18	2.61	2.82	4.24	5.57
F	3.06	3.30	2.95	5.84	4.39	2.43	4.60	3.73	3.58	5.88	3.68	3.20	3.50	3.45	3.04	2.96	3.37	3.59	5.41	5.43
G	2.70	2.32	2.04	2.27	3.56	2.14	2.51	2.92	2.27	2.60	2.85	1.90	4.18	2.72	3.79	2.42	2.24	2.34	4.52	4.17
H	2.68	2.97	2.63	2.86	4.09	2.20	3.90	3.41	3.25	2.49	3.35	2.87	2.94	3.11	4.33	2.61	3.03	3.25	4.64	4.58
I	3.82	3.22	2.87	3.12	4.18	2.92	4.53	3.67	3.50	3.63	3.61	3.12	3.89	3.37	4.34	2.87	3.29	3.51	5.82	5.68
K	4.50	3.32	2.70	2.95	4.55	2.49	4.00	3.50	3.33	4.30	3.44	2.95	4.66	3.21	3.42	2.96	3.12	3.34	5.79	5.79
L	3.51	3.19	2.83	3.08	3.46	2.06	4.13	3.63	3.46	3.58	3.57	3.07	3.30	3.33	4.28	2.81	3.25	3.46	5.36	5.17
M	3.82	3.16	2.82	3.06	6.04	2.32	4.10	3.61	3.44	3.57	3.55	3.06	3.87	3.31	4.32	2.80	3.23	3.44	5.00	3.71
N	2.38	2.70	2.33	2.58	4.33	1.92	3.63	3.13	3.09	3.08	3.07	2.58	2.64	2.84	4.29	2.32	2.75	2.96	4.43	4.49
P	2.72	3.07	2.71	2.96	4.24	1.77	4.01	3.53	3.34	3.47	3.45	2.95	3.42	3.21	5.39	2.67	3.12	3.33	4.90	4.42
Q	2.49	2.78	2.44	2.68	3.91	2.13	3.72	3.23	3.05	3.19	3.16	4.05	4.18	2.93	4.31	2.42	2.85	3.06	4.48	4.07
R	3.34	3.88	3.57	3.73	4.03	2.98	4.65	3.90	3.87	3.13	3.88	3.85	4.82	4.02	3.57	4.21	3.85	3.84	4.80	4.98
S	2.51	3.00	2.50	2.74	3.89	2.07	3.78	3.29	3.12	3.24	3.22	2.74	2.78	2.99	4.37	2.76	5.39	3.11	4.64	4.18
T	2.70	3.16	2.66	2.90	4.74	2.00	4.60	3.45	3.28	3.41	3.38	2.90	3.54	3.15	4.44	2.93	3.36	3.27	5.37	4.95
V	2.74	3.06	2.71	2.95	5.04	2.96	4.00	3.51	4.89	4.89	3.44	2.95	3.38	3.20	4.28	2.68	3.12	3.33	5.85	5.15
W	3.56	3.29	3.01	3.21	4.32	2.23	5.29	3.72	3.59	4.52	4.02	3.26	3.66	3.46	4.40	3.06	3.20	3.30	4.56	4.42
Y	3.34	3.15	2.83	3.05	4.22	2.82	5.29	3.59	3.21	4.09	3.54	4.29	3.14	3.30	4.41	3.39	3.23	3.46	5.09	4.32

^**Values in BLUE are predicted ones and in BLACK are actual ones.

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon AtomicCom

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	4.29	5.01	3.03	3.24	3.78	2.60	3.28	5.47	4.12	3.73	4.04	3.68	4.54	3.91	4.02	3.59	3.48	3.10	5.00	4.85
C	4.63	6.14	4.24	4.51	5.71	3.56	4.69	5.31	4.80	4.68	4.96	4.76	4.81	4.98	5.20	4.67	4.56	4.63	6.17	5.85
D	2.42	4.38	2.60	2.80	3.44	5.67	2.98	3.61	3.29	2.70	3.22	3.04	5.67	3.28	3.52	2.96	2.85	2.93	4.89	4.15
E	2.00	4.45	2.61	3.00	4.67	2.00	3.06	3.69	3.18	3.07	3.34	3.12	2.92	3.35	3.18	3.03	2.93	3.01	4.56	5.57
F	3.54	5.38	3.16	5.84	5.00	2.43	3.95	4.03	3.58	5.88	5.14	4.18	3.50	4.24	3.04	3.93	4.26	4.11	5.41	5.43
G	2.70	3.97	2.04	2.27	3.56	2.14	2.51	2.92	2.27	2.60	2.85	2.61	4.18	2.72	3.79	2.42	2.24	2.34	4.52	4.17
H	2.92	4.58	2.74	3.02	4.08	2.20	3.32	3.82	3.32	2.49	3.47	3.26	3.31	3.49	3.72	3.17	3.06	3.14	5.75	4.58
I	3.82	5.33	3.50	3.77	4.18	2.92	3.95	4.74	4.06	3.95	4.22	4.01	3.89	4.24	4.47	3.93	3.82	3.90	5.82	5.68
K	4.50	5.33	3.60	3.78	4.55	2.49	3.96	4.57	4.25	4.30	4.23	3.90	4.66	3.66	3.42	3.93	3.83	4.72	5.79	5.79
L	3.51	4.74	2.71	3.18	3.46	2.06	2.75	3.98	3.72	3.55	3.63	3.42	3.47	3.65	3.34	3.33	3.23	4.22	5.36	5.17
M	3.82	5.01	3.17	3.45	6.04	2.32	3.62	4.25	3.74	3.63	4.03	3.69	3.87	3.92	4.15	3.60	3.49	3.57	5.00	3.71
N	3.12	4.58	2.73	3.00	4.33	1.92	3.18	3.81	3.09	3.19	3.46	3.34	2.64	3.74	3.71	3.16	3.05	3.13	4.69	4.49
P	3.54	4.83	3.22	3.10	3.86	1.77	3.44	3.99	4.04	3.47	3.74	3.23	3.65	4.08	5.39	3.41	3.31	2.92	4.58	3.93
Q	3.55	5.00	3.16	3.43	4.49	2.13	3.61	4.24	3.05	3.61	3.89	4.05	4.18	4.02	4.14	3.59	3.48	3.56	5.10	4.77
R	3.34	5.15	3.33	3.28	4.03	2.86	3.78	4.39	2.94	3.13	4.05	3.84	4.82	4.06	3.57	4.21	3.65	3.72	4.80	4.98
S	3.28	4.75	2.89	3.17	3.89	2.07	3.35	3.98	3.47	3.35	3.63	3.41	3.46	3.64	4.22	3.38	5.39	3.30	4.85	4.18
T	3.26	4.71	2.87	3.14	4.74	2.00	3.32	3.95	3.44	3.33	3.60	3.38	3.54	3.61	3.85	3.48	3.28	3.27	4.26	4.49
V	3.55	5.24	3.40	3.67	5.04	2.96	3.85	4.47	4.89	4.89	4.13	3.92	3.38	4.14	4.28	3.83	3.72	3.91	5.85	5.15
W	3.56	5.38	3.87	3.83	4.87	2.23	5.29	4.91	4.38	4.52	4.02	4.07	3.66	4.29	4.17	3.98	3.20	3.30	5.74	4.42
Y	3.34	5.30	3.47	4.49	5.02	2.82	5.29	5.02	3.21	4.09	3.26	4.29	3.14	4.21	4.44	3.39	3.79	3.91	5.09	5.29

^**Values in BLUE are predicted ones and in BLACK are actual ones.

AHTpin

Antihypertensive Peptide Inhibitors

Antihypertensive Activity of Peptides

20 x 20 Matrix representing Dipeptides' pIC50 (AHTPs) Based upon AACom

20 x 20 Matrix representing Dipeptides' pIC50 (AHTPs) Based upon Descriptors

20 x 20 Matrix representing Dipeptides' pIC50 (AHTPs) Based upon AtomicCom

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon AACom

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon Descriptors

20 x 20 Matrix representing Dipeptides' pIC₅₀ (AHTPs) Based upon AtomicCom