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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 650
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1575Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic20LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM24CFU/well 3.11 ± 0.09 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1576Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic21LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM25CFU/well 3.19 ± 0.05 at peptide concentration 4 μg/ml +INH 4μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1577Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic22LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM26CFU/well 3.08 ± 0.09 at peptide concentration 64 μg/ml +INH 4μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1578Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 3.10 ± 0.08 at peptide concentration 8 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1579Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 3.00 ± 0.10 at peptide concentration 16 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1580Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 3.05 ± 0.11 at peptide concentration 32 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1581Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.88 ± 0.06at peptide concentration 64 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1582Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.71 ± 0.09 at peptide concentration 128 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1583β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.11 ± 0.10 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1584β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.15 ± 0.0.16 at peptide concentration 64 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1585β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 1.31 ± 0.10 at peptide concentration 4 μg/ml + INH 0.06 μg/mlin vitroNANANANA NANABacterial membrane pore formationNApeptide +INHNA200415245864
antitb_1586β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NANABacterial membrane pore formationNApeptide +INHNA200415245864
antitb_1587β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.15 ± 0.20 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1588β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.21 ± 0.42 at peptide concentration 8 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1589β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 3.02 ± 0.30 at peptide concentration 16 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1590β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 2.991± 0.23 at peptide concentration 32 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1591β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 2.90± 0.20 at peptide concentration 64 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1592β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 2.80 ± 0.15 at peptide concentration 128 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1593β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.91 ± 0.19 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1594β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.89 ± 0.19 at peptide concentration 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1595β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.70 ± 0.15 at peptide concentration 64 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1596β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.90 ± 0.09 at peptide concentration 4 μg/ml + INH 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1597β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.91 ± 0.19 at peptide concentration 64 μg/ml + INH 4 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1598β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.93 ± 0.07 at peptide concentration 8 μg/mlin vitroNANANANA NANABacterial membrane pore formationNAINH+peptideNA200415245864
antitb_1599β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.78 ± 0.15 at peptide concentration 16 μg/mlin vitroNANANANA NANABacterial membrane pore formationNAINH+peptideNA200415245864
antitb_1600β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.80 ± 0.14 at peptide concentration 32 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1601β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.66 ± 0.15 at peptide concentration 64 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1602β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 2.60 ± 0.17 at peptide concentration 128 μg/mlin vitroNANANANA NANABacterial membrane pore formationNANANA200415245864
antitb_1603Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis H37RvCFU/well 0.68 ± 0.30 at peptide 64ul + 4 ul of INHin vitroNANANANA NANABacterial membrane pore formationNAPeptide(64 ul) + INH(4 ul)NA200415245864
antitb_1604Protegrin -1RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-14Cyclic18LCationicNaturalDerived from porcine leucocyteMycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 1.99 ± 0.44 at peptide 64ul + 4 ul of INHin vitroNANANANA NANABacterial membrane pore formationNAPeptide(64 ul) + INH(4 ul)NA200415245864
antitb_1605β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis H37RvNAin vitroNANANANA NANABacterial membrane pore formationNAPeptide(64 ul) + INH(4 ul)NA200415245864
antitb_1606β-Defensin-1(HBD-1)DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCKFreeFreeDisulphide nlinkage between cys5-34, cys12-27, cys17-35.Cyclic36LCationicNaturalDerived from beta defensin 1 OF HUMAN Mycobacterium tuberculosisMycobacterium tuberculosis RM22CFU/well 0.90 ± 0.75 at peptide 64ul + 4 ul of INHin vitroNANANANA NANABacterial membrane pore formationNAPeptide(64 ul) + INH(4 ul)NA200415245864
antitb_1628LL-37LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESFreeFreeNoneLinear37LCationicSyntheticNAMycobacterium smegmatisMycobacteria smegmatis mc2 155MIC = 2400 μg/mlin vitro J774 macrophage cell linesNAIC50= 11226 μg/mlNA NAStimulation of TNF-α productioninhibit bacterial Atpase activityNANANA201526218806
antitb_1629LLAPRKSAKKIGKRAKRFreeFreeNoneLinear13LCationicNaturalNAMycobacterium smegmatisMycobacteria smegmatis mc2 155MIC = 600 μg/mlin vitro J774 macrophage cell linesNAIC50= 11226 μg/mlNA NAStimulation of TNF-α productioninhibit bacterial Atpase activityNANANA201526218806
antitb_1648Tuftsin peptide conjugate compoundEFAGAGFVRAGALINH is conjugated FreeNoneCyclic13LCationicNaturalDerived from 16-kDa protein of M. tuberculosis and tuftsin-derived peptidesMycobacterium Tuberculosis Mycobacterium tuberculosis H37Rv ATCC 27294MIC = 2.52 μg/mlin vitroNANANANA NANACell wall biosynthesis inhibitionNAPeptide + INH(0.24 ug/ml)NA200919319854
antitb_1649Tuftsin peptide conjugate compoundSEFAYGSFVRTVSLPVINH is conjugated FreeNoneCyclic16LCationicNaturalDerived from 16-kDa protein of M. tuberculosis and tuftsin-derived peptidesMycobacterium Tuberculosis Mycobacterium tuberculosis H37Rv ATCC 27294MIC = 2.54 μg/mlin vitroNANANANA NANACell wall biosynthesis inhibitionNAPeptide + INH(0.24 ug/ml)NA200919319854
antitb_1650Tuftsin peptide conjugate compoundSEFAYGSFVRTVSLPVINH is conjugated FreeNoneCyclic16LCationicNaturalDerived from 16-kDa protein of M. tuberculosis and tuftsin-derived peptidesMycobacterium Tuberculosis Mycobacterium tuberculosis H37Rv ATCC 27294MIC = 2.26μg/mlin vitroNANANANA NANACell wall biosynthesis inhibitionNAPeptide + INH(0.24 ug/ml)NA200919319854
antitb_1651Human neutrohil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicSyntheticHuman neutrophil Mycobacterium Tuberculosis Mycobacterium tuberculosis H37RvIC50 = 0.8μg/mlin vitromurine macrophage-like cell line J744A.1NAcytotoxic at above concentration 5 ug/mlNA NANAMicrobial membrane disruptionNANANA201610933095
antitb_1652Human neutrohil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicSyntheticHuman neutrophil Mycobacterium Tuberculosis Mycobacterium tuberculosis H37RvIC90 = 2.5 μg/mlin vitromurine macrophage-like cell line J744A.1NANANA NANAMicrobial membrane disruptionNANANA201610933095
antitb_1653NAWKWLKKWIK FreeFreeNoneLinear9LCationicSyntheticNAMycobacterium Tuberculosis Mycobacterium tuberculosis H37RvIC90 = 1.5 μg/mlin vitroHuman THP-1 cell linesNANANA NANAMicrobial membrane disruptionNANANA201626645944
antitb_1672Lariatin AGSQLVYRWVGHSNVIKGPFreeFreeAlpha carbon of glutamine form amide bond with first glycine and gamma carbon of glutamine involved in side chain formationCyclic18DCationicNaturalRhodococcus jostii B0171Mycobacterium smegmatis Mycobacterium smegmatis ATCC607MIC = 10 μg/mlin vitro NANANANA NANANANANANA200717617692
antitb_1673Lariatin BGSQLVYRWVGHSNVIKGPFreeFreeAlpha carbon of glutamine form amide bond with first glycine and gamma carbon of glutamine involved in side chain formationCyclic18NACationicNaturalRhodococcus jostii B0171Mycobacterium smegmatis Mycobacterium smegmatis ATCC607MIC = 10 μg/mlin vitro NANANANA NANANANANANA200717617692
antitb_1675Wollamides 5WLLVNGFreeFreeNACyclic6DCationicNaturalStreptomyces species MST-115088Mycobacterium bovis Mycobacterium bovis BCGIC50 = 2.8 μg/mlin vitro NANANANA NANANANANAAntibacterial against staphylococcus aureus and bacillus subtilis201425229313
antitb_1676Wollamides 6WLV-allo-INGFreeFreeFourth amino acid is allolysine and form cyclic structure with 1st and 6th Cyclic6DCationicNaturalStreptomyces species MST-115088Mycobacterium bovis Mycobacterium bovis BCGIC50 = 3.1 μg/mlin vitro NANANANA NANANANANAAntibacterial against staphylococcus aureus and bacillus subtilis201425229313
antitb_1702Human neutrophil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosis Mycobacterium tuberculosis Ra 7632GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802
antitb_1703Human neutrophil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys30Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosis Mycobacterium tuberculosis Ra 9034GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802
antitb_1704Human neutrophil peptide (HNP-1)ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys31Cyclic30LCationicNaturalHuman neutrophil Mycobacterium tuberculosis Mycobacterium tuberculosis Ra 11170GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802
antitb_1708Porcine leucocyte peptide (PG-1)RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-13Cyclic18LCationicNatural porcine neutrophil leucocyteMycobacterium tuberculosis Mycobacterium tuberculosis Ra 7632GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802
antitb_1709Porcine leucocyte peptide (PG-1)RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-14Cyclic18LCationicNatural porcine neutrophil leucocyteMycobacterium tuberculosis Mycobacterium tuberculosis Ra 9034GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802
antitb_1710Porcine leucocyte peptide (PG-1)RGGRLCYCRRRFCVCVGRFreeFreeDisulphide linkage 6-15 and 8-15Cyclic18LCationicNatural porcine neutrophil leucocyteMycobacterium tuberculosis Mycobacterium tuberculosis Ra 11170GReduction in CFU at 50 μg/mlin vitroNANANANA NANAMicrobial membrane disruptionNANANA19968641802