Protein-based Vaccine Adjuvants

This module takes protein sequence in single letter code and predict highly potential immunomodulatory regions in a protein. It also predict important physicochemical properties. In addition, this module also suggest mutations required in immunomodulatory regions to enhance/reduce its potential. User may identify proteins which are dominated by immunomodulatory peptides or A-cell epitopes. One may also identify vaccine adjuvants from pathogenic proteins.

Type or paste protein sequence in single letter code:
Choose fragment length:     Select fragment length in which you want to fragment your protein(s). 10 15 20 25 30 35 40 45 50
Select prediction method:     Please select prediction method, SVM-based or SVM+motif-based, if you need motif information for prediction.

 Dipeptide Composition

Dipeptide Composition + Motif

Choose SVM threshold: 0.0 -1.0 -0.9 -0.8 -0.7 -0.6 -0.5 -0.4 -0.3 -0.2 -0.1 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0     SVM threshold is required for prediction. Moving the threshold value
in either direction (+1 or -1) will lead to increase
in probability of correct prediction in that direction.

Optional (Peptide Property)

This server allow users to compute physicochemical property of residues. Please select property you wish to calculate

  Hydrophobicity

  Steric hinderance

  Solvation

  Hydropathicity 

   Amphiphilicity

  Hydrophilicity

  Net Hydrogen

   Charge

   pI

   Molecular weight

All