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SAL_25486 details
Primary information
SALIDSAL_25486
Biomarker nameSOX10
Biomarker TypeDiagnostic
Sampling MethodA 44-year-old Japanese woman, who had a smoking habit, underwent subtotal tongue root resection for a solid mass located in the anterior mesopharynx after chemoradiation therapy
Collection MethodNA
Analysis MethodIHC
Collection SiteWhole Saliva
Disease CategoryCancer
Disease/ConditionSalivary gland Cancer
Disease SubtypeSalivary hyalinizing clear cell carcinoma
Fold Change/ ConcentrationNA
Up/DownregulatedDownregulated
ExosomalNA
OrganismHomo sapiens
PMID29434341
Year of Publication2018
Biomarker IDSOX10
Biomarker CategoryGene
SequenceAGTCGCTCAGTCAGTCTCGGGCTGTCCGGCCAGGGTGGTTGGTGGTAAGGATTCAGGCTCCGTCCTAACGAGGCCGTGGCCTGAGGCTCAGGGCCCCCCGCCCCTCCCTCCCAGCCCACCAGCGTCACCTCCCAGCCCCGAGCTGGACCGCACACCTTGGGACACGGTTTTCCACTTCCTAAGGACGAGCCCCAGACTGGAGGAGAGGTCCGAGGAGGTGGGCGTTGGACTCTTTGCGAGGACCCCGGCGGCTGGCCCGGGGGAGGCGGCCGAGGCGGCGGCGGCGGCGGCCGGGGGCGACATGGCGGAGGAGCAGGACCTATCGGAGGTGGAGCTGAGCCCCGTGGGCTCGGAGGAGCCCCGCTGCCTGTCCCCGGGGAGCGCGCCCTCGCTAGGGCCCGACGGCGGCGGCGGCGGATCGGGCCTGCGAGCCAGCCCGGGGCCAGGCGAGCTGGGCAAGGTCAAGAAGGAGCAGCAGGACGGCGAGGCGGACGATGACAAGTTCCCCGTGTGCATCCGCGAGGCCGTCAGCCAGGTGCTCAGCGGCTACGACTGGACGCTGGTGCCCATGCCCGTGCGCGTCAACGGCGCCAGCAAAAGCAAGCCGCACGTCAAGCGGCCCATGAACGCCTTCATGGTGTGGGCTCAGGCAGCGCGCAGGAAGCTCGCGGACCAGTACCCGCACCTGCACAACGCTGAGCTCAGCAAGACGCTGGGCAAGCTCTGGAGGCTGCTGAACGAAAGTGACAAGCGCCCCTTCATCGAGGAGGCTGAGCGGCTCCGTATGCAGCACAAGAAAGACCACCCGGACTACAAGTACCAGCCCAGGCGGCGGAAGAACGGGAAGGCCGCCCAGGGCGAGGCGGAGTGCCCCGGTGGGGAGGCCGAGCAAGGTGGGACCGCCGCCATCCAGGCCCACTACAAGAGCGCCCACTTGGACCACCGGCACCCAGGAGAGGGCTCCCCCATGTCAGATGGGAACCCCGAGCACCCCTCAGGCCAGAGCCATGGCCCACCCACCCCTCCAACCACCCCGAAGACAGAGCTGCAGTCGGGCAAGGCAGACCCGAAGCGGGACGGGCGCTCCATGGGGGAGGGCGGGAAGCCTCACATCGACTTCGGCAACGTGGACATTGGTGAGATCAGCCACGAGGTAATGTCCAACATGGAGACCTTTGATGTGGCTGAGTTGGACCAGTACCTGCCGCCCAATGGGCACCCAGGCCATGTGAGCAGCTACTCAGCAGCCGGCTATGGGCTGGGCAGTGCCCTGGCCGTGGCCAGTGGACACTCCGCCTGGATCTCCAAGCCACCAGGCGTGGCTCTGCCCACGGTCTCACCACCTGGTGTGGATGCCAAAGCCCAGGTGAAGACAGAGACCGCGGGGCCCCAGGGGCCCCCACACTACACCGACCAGCCATCCACCTCACAGATCGCCTACACCTCCCTCAGCCTGCCCCACTATGGCTCAGCCTTCCCCTCCATCTCCCGCCCCCAGTTTGACTACTCTGACCATCAGCCCTCAGGACCCTATTATGGCCACTCGGGCCAGGCCTCTGGCCTCTACTCGGCCTTCTCCTATATGGGGCCCTCGCAGCGGCCCCTCTACACGGCCATCTCTGACCCCAGCCCCTCAGGGCCCCAGTCCCACAGCCCCACACACTGGGAGCAGCCAGTATATACGACACTGTCCCGGCCCTAAAGGGGGCCCTGTCGCCACCACCCCCCGCCCAGCCCCTGCCCCCAGCCTGTGTGCCCTGTTCCTTGCCCACCTCAGGCCTGGTGGTGGCAGTGGAGGAGGCTGAGGAGGCTGAAGAGGCTGACAGGTCGGGGGGCTTTCTGTCTGGCTCACTGCCCTGATGACCCACCCGCCCCATCCAGGCTCCAGCAGCAAAGCCCCAGGAGAACAGGCTGGACAGAGGAGAAGGAGGTTGACTGTTGCACCCACACTGAAAGATGAGGGGCTGCACCTTCCCCCAGGAATGACCCTCTATCCCAGGACCTGAGAAGGGCCTGCTCACCCTCCTCGGGGAGGGGAAGCACCAGGGTTGGTGGCATCGGAGGCCTTACCACTCCTATGACTCCTGTTTTCTCTCTCACAGATAGTGAGGGTCTGACATGCCCATGCCACCTATGCCACAGTGCCTAAGGGCTAGGCCACCCAGAGACTGTGCCCGGAGCTGGCCGTGTCTCCCACTCAGGGGCTGAGAGTAGCTTTGAGGAGCCTCATTGGGGAGTGGGGGGTTCGAGGGACTTAGTGGAGTTCTCATCCCTTCAATGCCCCCTCCCTTTCTGAAGGCAGGAAGGAGTTGGCACAGAGGCCCCCTGATCCAATTCTGTGCCAATAACCTCATTCTTTGTCTGAGAAACAGCCCCCAGTCCTCCTCCACTACAACCTCCATGACCTTGAGACGCATCCCAGGAGGTGACGAGGCAGGGGCTCCAGGAAAGGAATCAGAGACAATTCACAGAGCCTCCCTCCCTGGGCTCCTTGCCAGCTCCCTCTTCCCTTACTAGGCTCTATGGCCCCTGCTCAGTCAGCCCCACTCCCTGGGCTTCCCAGAGAGTGACAGCTGCTCAGGCCCTAACCCTTGGCTCCAGGAGACACAGGGCCCAGCACCCAGGTTGCTGTCGGCAGGCTGAAGACACTAGAATCCTGACCTGTACATTCTGCCCTTGCCTCTTACCCCTTGCCTCCCAGTGGTATTTGAATAAAGTATGTAGCTATATCTGCCCCTATTTTCCTGTTCTGCAGCCCCCCAAATCCACATGTAACTCATTACTGTCTCCTGTTATTTATCTCAGTAGTCCCCTCTCCTAGCCACTCTAGCCCCTATTAACTCTGCATTAAGCATTCCACATAATAAAATTAAAGGTTCCGGTTA
Title of studyHyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas
Abstract of studyHyalinizing clear cell carcinoma of the bronchial glands is a very rare tumor. Since only five reports describing six tumors have been published to date, only a little is known about specific histologic findings and clinical features. Because of its rarity, hyalinizing clear cell carcinoma has not been described in the latest WHO classification of pulmonary tumors yet. Here we present three cases of bronchial hyalinizing clear cell carcinomas, confirmed by both fluorescence in situ hybridization (FISH) and RT-PCR, focusing on histologic and immunohistochemical characteristics in a comparison with three cases of salivary gland origin. In addition, we compared immunohistochemical features with bronchial mucoepidermoid carcinoma, a lesion that needs to be taken into account in differential diagnosis of hyalinizing clear cell carcinoma. All our bronchial hyalinizing clear cell carcinoma cases were surgically resected. Histologically, tumor cells showed clear to eosinophilic cytoplasm with hyalinizing stroma in various proportions, resembling those of salivary gland origin. Immunohistochemically, tumor cells were positive for CK7, CK5/6, p40, p63, and ATF1, while they were negative for TTF1, Napsin A, HMB45, and SOX10. The CK5/6 staining pattern varied in mucoepidermoid carcinomas, while that of hyalinizing clear cell carcinoma was uniformly positive. FISH revealed EWSR1-ATF1 fusion, and RT-PCR with sequencing confirmed specificity of the chimeric gene for hyalinizing clear cell carcinoma. Clinically, bronchial hyalinizing clear cell carcinoma was characterized by occurrence in the fourth to sixth decades, no link with smoking history, and a predilection for the right lung, in line with previous reports. In summary, our study confirmed that the bronchial hyalinizing clear cell carcinoma is a histologically and genetically identical tumor to that of salivary gland origin, and that gene rearrangement analysis can play a critical role in distinction from mucoepidermoid carcinoma.