| Primary information |
|---|
| SALID | SAL_25247 |
| Biomarker name | C1S |
| Biomarker Type | NA |
| Sampling Method | This study included 41 OSCC patients and 10 healthy volunteers (HV) |
| Collection Method | Saliva samples were collected using an Oragene¨ RNA Self-Collection kit. Via the spitting technique, subjects were asked to collect 2ml of their saliva in a tube within 15 min |
| Analysis Method | qRT-PCR |
| Collection Site | Whole Saliva |
| Disease Category | Healthy |
| Disease/Condition | Healthy |
| Disease Subtype | NA |
| Fold Change/ Concentration | NA |
| Up/Downregulated | NA |
| Exosomal | NA |
| Organism | Homo sapiens |
| PMID | 32871760 |
| Year of Publication | 2020 |
| Biomarker ID | C1S |
| Biomarker Category | Gene |
| Sequence | AACTAACAAGGCACTGAAGAGCCCACAGCTTGGGGCTCATGGGGACAAGGTCAGGAGATGGTGGGAGGGGATGCAAATTTAGAAGTTCCACCTACGAGGATCCCGATATGGCAAGTACAAAATGCCCAATTAACCTTTTTCTACATGTTTTCTTCCAATGGTGTTTAAGTTCACAGGACATAGACTTTTTTTTTTGACAGGGTCTCACTCTATTGCCCAGGCTGGAGTGCAGTGGTGTGATCACAGCTCATTGCAGCCTTGACCTCCAGGGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGACATGCTCTAGCATGCCTGGCATTCTTTCTTTTTTTTGTGGAGATAGGGTCTCACCATGTTGCCCAGGCTGATCTCAAACTCCTGAACTCAAGCAACCCTCCTGCTTTGGCCTCCTAAAGTATTGGTATTACAGGTGTGAGCCACCACACCTGGCCCACAGGACATGGATTCTGAACAACTGGCATAAATCGACTGGCCTCAAGGTAAGGTTTTAAACTAAGCTTAAGCTTTTCTGTTGCCCTCAGATACCACTGAATTTCTTCTTCAGATTTTGGTGACATTAAGTGGTGGTTTCTGGAAATACAATTTTAATTTTGCTTGGGATGATTGTCTTGGGGTCTGGGGATAGCTCATTTTCTAAATTTTGTGGTTGTGGGGCTGGTGTTGCAATATTCTTGTGTCTCATTAACTTTCTGGAATTTTAAAAACAGACTCATGGAAGGTTTGCCTCAGAACTCAGTCTTTGAAGCCTTGGAGGAACTAACCTGTTCCAGCCCAGGCCGCAGCTTCGGAAGGGACCACAGCTCTGCCCAGGGATTGGAAACCCACTAGCTGGGATTAAACAGAACACAAATTGGAACTGATAGTTTTGTGACTTTAACATAGACACTTTGGGCTTCAATTACTTTTGACTTTAATGTCATAGTTTCAGTTTGCAATGGGATTTGAACTTTAATTTTGGAGTTTGATTAATGGGAGGGTTATTTGTTGTTCAAATTTGAAAATGGGAGGGTTATTTGTTGTTCAAAACCTTTATTGTTGGCAATCCCTTGTTGGAGCTTCTTAATACCATCATTTAATCTCATTGTGGATCTCCGATAGCTACTTAGATAACATGGCTGCATGAAATTTTATTTTATTTATTTTTGAGACAGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCATTGCAGCCTCAAAATCCTGGGCTCAAGTTATCCTCCTCCCTTGGCCTCCTGAGTAGCTGGGACTACAAGTGCGTGCCACTATGCCTGACTAATTTTTTGACTTTTTGTAGAGATGAAATCTTGCTATGTTCCCCAGGCTGGTCTTGAACTCCTGGCATCAAGTGATCCTCTCTTTTTGGTCTACCAAAGTGCTGGGATTACAGCACTTTGGCATGAGCCACTATGCCTGACCAATGAAATTTGAGGTGGGAAACGGAGCACCCAGGCTGAAGTGCAATGCTGTGGTCATAGCTCACTGCAGGCTTGAACTCCTGGGCTCAAGCAATCCTCCTGCCTCTCAGCCTCCTGAGTAGCTGGGACCACAGGATGGCTAATTTTTAAACTTTTTTGTAGAGATGAGGTCTCCCTATGTTGCCTAGGCTGGTCTTGAACTCCCAGCCTCAAGCGATCCTCCCGCCTCAGCCTTCTGAGTTGCTGGGATTACAGGTGTGAGCCACTGCTCCTGGCAATGTATTTCAATTTCGTGGCAAAATTGCAGAAATGAACATAAAACACAGGTGAGGATAGGAGAGTCTAACTTTTCTGGCAAGATCGGGCAGTGTTGAGCTCCAAGGAAAAGGAGAAGGAACCCTGGACACATTGATAAGGCGTCCTCTTTTCCTTGGTATTAACTGAAGCATGCTCTTGATGGGGAGGAAGCTGCTGCTACTGCTGCCGTGTTTGGTGTTTGGAGAAGTTAATATGGTTTGTTATTTGTTAAAAGCTTACTGAGTACCAGGTATATGCTGAATGCTTAGCATACGTTATTTTGTTTAATCTTGGCCACAATGGGCCCTGACAGTGATAGCTGTGTCTGAAGTAGGTGCTATTATTCCCATTTTACACCTGATAAAGCTGGAGCTCAGAGAGGCATAGTAACTTTTTCAAGGTCACACGGCTAAAATGAAAGGTAATGAATGGTTTGAATTCACTTTGGCACATTCAATCAACCAATCCTCAGATACTCACTGAGCGTGTTGTATCAGCCATTATTTTTAGTTGCAAGCAGTAGAAACCAACTCTGGCTGAGTTTAGCAGAAGATGAATTTATTAAAGGGACCCTGGATTGCTCATGGAAATTCCAGGGGAGCTACAGAGCCATTGTGGAAGCTTCCCAGCAGGGACAATGGTCAGAACCTGGCTGCCGCTGCTGCCACTTCTTTGACCATGGCCTGGATGCTTCGGCTTGCAATGCTTACCCACTGGGGCTGGATGCTGGGTGCTGCTGAGAACTCTACCTCCTCTGTGATCTTGCTGTGGCCACCACTGTCCCTACAGGCTCTAGGGTCCCTGCTTCCTGGCATTACTGGCTCTGGATTGAAAGCCTGGGCCTCTGATGAATGGAACGTGTGTGCATGTGAAACTGCCTTTGCAAAGATGATGACAGTGAGGGAAGTCTAGCATGGGTGACTCCATCTTGCCTCTACCCTCACAGGCTGGCTGTCCTCACTCATTCCTGGGCATAGGCCAAGCTAACCATGGGAGGAATTTAGTTTACAGTTTAACTCTGAAGCAAAGATGATATTAGTCCCTCCCTAAAATGAACCCCCTCCTAGCTCAGGGACCTGCCTTTGTAAAACTAATGAAAGGCCACAAGATTAGGATTATGGGAGGGGCTTGAATTTTGCTAAGATGTGGGTGTAGCTAACCGATGACCAGCCATTGACCCCTAGCTTGCCTTTCTATAATCCTTTGCTGCTCAGGAGTCATGCGGCCAGAGGTCACAAGATCTGTGACTTCCCCAATTGCTCCTATAGATAACATCACTATTGTAAAACCAAATATTGGTCTTCTGAGATATTTTTCAGACTTTTGCATTCTGAAATGATTCATGACTCAACTGGTCCTGTGACCCCCACCCAGAGGTGGACTTAGTGCACAAGGTCTGTTTTCTACACTCCTATGATTTTATCCCCAACGAATCAGTAGCACCCATTCTCTGCTCTTACCGCCCACCAAATTCTCCTTAAGAACCCTAGCCTCTGAGTTCTTGTGGGGACTGATTTGAGAAATAAACTCCCATCCTTTCACTTGGCTAGCTCTGTGTTGTTAAACTCTTTCTCTACTGCAATACCATGGTCTCAGTGAATTGGTTTTGTCTACGCAGCAGGCAGGAAGAACCCTTCGGGTGATTACAAATTAGCCTGCTCCAGAGCTGCTGGAGGTGGGGGTGACACACTTCTTGTGCCTGTGTCTTCTTTCTTGGGAGGTCGGCTCTGTTCCCAAGACTGATATCATGGGGAACTCCTCTAATGTGGCAAAGCAGTTTGAATGCTGGGCAGCCAGGGGAGTCACAGATGGTTGCATACACATCTGTGTTCTGCATGACACTGCTAGACATGGCGGACAATACCAAGACGGATCAGACCCAGCACCTGTCTTCCGAGACCTTACGGGCTCATGATTCTCTTCCTTTTAACATGCACATTTATTAGGTACCATAGTGTGCAAAGCTTGTTCACTCGAATTATTTCATTAGGTCCATCTGATAGTCATGTAGGGTAGGCAGAACTGATAGGATTTCTGTTTTATATTTGAAGAAACTAGGTCTGTCAATAGTGAGCCAGGTTTAAAAAAAAAAAGAAACTAGGAAGTTAGGTGATGAGCCTAAGACATCACCACTGGTGAGGAGCAGAGCTGGGACATGAGCCTATCTTCTGACTCCAGGCCCAGTGCTAAGCCAACTAAAGGGGCATAAAGGGGAGCTGAGATCAGGGAAGGCTCTGTGGAGTGGCACTGCCCCTCAGTCCCTTGTCTGCAATTCTAAAATCCAAAGGACTCTGAAAACAAAGTCTCTGTCTTTTTTTTGTAATGGGATCTCATTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCCCTCTGCAGCCTCGACCTCCCTGGCACAAGTGATCCTCTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGTGTGTCACAATACCTGGCTATTGTTTTTTGTTTGTTTGTTTTCAAGTTTGGGACTAAAACTCAATTTGGCAGCAAAACCTGACCCGAACTGATGTGATTTGTAATCTTTAGTTATCCATTTACCGTAAGATCAATGTGTTTAGCTGCAGAAATCTTAATGTTTGTTAATAGGGGGTTATCCTGGTCCATAAAGGGAGGGAGAGGAGGAGGTGTTACCTAATATTGGGTCCATGGACTACATAGCCTAAAAAAATCTATAAAATTTCAAAACACACCTGGCTTCAAGGGTTATGGATAAGGGAGTCTGGGTTGGATCTGAAAGGGGGCTTGGTTGTGGGGTAGAATTTCGATGTTTGGAAGGGATGTGGAGGGATGTTATGAAGAGGAAGCCTCACGCCATACCACCTTGGGTCTTGGTGTTAAGTCATTATCAACCATTACATTTGCTTTAAAGCAGAGATGACTTACATTTCTGATAACTACTTTCCCTTAATTCATGATTCACACACATTTGGAGGGCTGGACTTTCTGGGTTTGGTTATTTCCCCTGGTACCAATCCCCGCCTTTTCCCAGAAATCACTTGACTTTCCCGAAAACTCAGAAACACACCCTTTGGCTGAAAAATAGCATTAAGCAATCGGTGAAATTCCCCATTCCTCCTTTCCCCGCTGGAGCCCTGGATAGAGGGCTCTCTGGCCTGGGAGGAGGACGCTGTCCTTGTTTCAAAAGCAGAGGGAGCTCCAAGATCAAGGCTGAGTTTCCCTAAGTCATGGTCTCCCAGCCCCCTCTGTTTAGATCAGGGAATTTCAGACATGCACACTCGGGTAGGGAATCTTATGAACAGAACCAGGACAGGGAGGCTGGCCGGAGGTTCCTGCAGAGGGAGCGTCAAGGCCCTGTGCTGCTGTCCCTGGGGGCCAGAGGGGTTGCCCAGCATGCCCACTGGCAGGAGAGAGGGAACTGACCCACTTGCTCCTACCAGCTTCTGAAGGTAAAATCCTTACAAACGAGGAGCAGAGCTTTGATGGAGGAAAAAGGAAAGGCAGAAAACTTCACGTAGGAGGGCTTGGGGCAATGATAGAGGGCTGACAAAGGCAGCATAAAAAAAGGCAGAATATAGACAACCTATTTCTCTTAGGCTCACCCCATCCACCCCTACTTCACCCCCTTACCTACCACTGTTTTCAGGGTTAAAGCAATTTTAGCAACCCTTTACTAGGAACTGTGGGGAGATAGCTTGTATTTTCAGTAAGTTGGCGGTGGGGGGCAGGGACAAACTCCAAACAAACTCTGGAAAACGAATGTAGGAAGTTTTTATGTTCCTTGTCATTTGGCTGTCCCTTTTCTCCTTCCTCGCACAACCCTGTATCAGTGGGGCAGCACTTCCTTCTCAGACCGCTTGTCCCAGGGTCCCTGCCTTCCCCTAGTGAAAGAAGCTCCTGCCTCCATCGGTGGGCGTTGGGAGCATCAGCGGAGATGCACGCAATGATAAACAGCAGACAGGGCTGCTTGAGGAGATGAGGTGATCACGGTTAAAGAAGAGGGGCTGTCCTACATGGATGATCATGATGCGCCAAGACTGTTGAAAACCTGAGTGGAAATGGGAGCATCGTTCTTGAGGGCAGGAGAGAGACTGATACCGCGGGGGTGGGGCTGGTGGAGGACAATAGAGGAAGAAGAAAACTGGGAGAAAGTACTCGATTCCTTTGGAGAAAAATTAGGAGAAAGTCTAGAGAAGCAATGAGGGAAGGATACAATTTAGCTATAGTCTAGAAAGTTAGTCGAAGTTAACTAGGGAGGGTGTGAGGGGCACGGTGCCATGTGGGGATGTTGGTGATATGGCCCTGTGTGTTATACCTTTGAAGGTGACACTGAGCCCCAGGTGACGCCGCACCACCAAAGAAGGTGCTTGTGTTTGTCAGACAAATACAGCCAGGCCTGCCACCCCTTAGGCTCCAAAGTCCGGAGGTGCAGAAAGCCAGGACCAAGAGACAGGCAGCTCACCAGGGTGGACAAATCGCCAGAGATGTGGTAAGTGATCAAGGGTCCCTGAGATGACACAGACTCCATTCCCTTCATCTTCTCAAGAAAAGCGCTCAAGGGCCAGGCATGATGGCTCACACCTGTAACCCCAGCACTTTGGGAGGCTGAGGCGGGAGGATTGCTTGAGCCCAGGACTTTGAGACCAGCCTGGGCAACATAAGGAGACCCTGTCTCTATTAAAAAAAAAAAAAATTAGCCCAGCGTCATGCGTGTCACCTGTGGTCCCTGCTACTCAAAAGGCTGAGGTGGTAGAATCACTTGAGCGCGGGAGGTCAAGGCTGCAGTGACCTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGAACCTGTCTCAAAAAAAAAAAAAAAAGGGCTCTTGTCTGAAGCCTGGGTTTTGGTTTGACCTGGGCCTTTTCTTTATTCCGACCTAAGATTCTCCCCCATGGCCGATTGACTGCCTCTCTTCTTCCCCCTTTCTTCTGCCTCTGGCAAATAGCGCGTTCTGTCCTAGGCTACTGGTGCCTGGTCACCCGCCAATCTATGCCTCTGTTTTTTCAGGTGCATTGTCCTGTTTTCACTTTTGGCATGGGTTTATGCTGAGCCTACCATGTATGGGGAGATCCTGTCCCCTAACTATCCTCAGGCATATCCCAGTGAGGTAGAGAAATCTTGGGACATAGAAGTTCCTGAAGGGTATGGGATTCACCTCTACTTCACCCATCTGGACATTGAGCTGTCAGAGAACTGTGCGTATGACTCAGTGCAGGTATGTTATAAGCACAAAAAGAATAGAGATGGAAGACTAGGGCTAAGGTAGCGGAATAAGGATGTGGGAGGGAGTGCCACCTGTACTCACAGTGAACTGGAGTCAAGTCCTAGTGGCATAAATGTTCTATTCTCTCTGTCCCTTCTTTTAACTCCATACCAAAATATTACCCTTTCCTAGATTTTTTTTTTGTGACTCTTCTCTTAGATAATCTCAGGAGACACTGAAGAAGGGAGGCTCTGTGGACAGAGGAGCAGTAACAATCCCCACTCTCCAATTGTGGAAGAGTTCCAAGTCCCATACAACAAACTCCAGGTGATCTTTAAGTCAGACTTTTCCAATGAAGAGCGTTTTACGGGGTTTGCTGCATACTATGTTGCCACAGGTAAGGCTCACCCTTCTGCATGTGCCTTATTGACCCAGCTAAAAGATTAGAAATGAGAAATCCACTGAGCAACACATTGAATGAGGATTCTGTTCGTAATTCTTATAAAAAGTGTTGACTTGGCCTGGGTCGCTCCATAAATCACTTTTGTGAAATTCAAATGCATGATCATATCTTAGTGGTGATGATGATCATGGTAATAACACATAGTACATAATAAACAGCAATTTGTTGAGAGCCACTATAAACTGGGTATGTATTGGGGATTGGGGATTTTTCCTATTTTAACACAATCGTCACTTTAATCCTTCAAGGTAGGTATTATTTGCTCCATATAAAGATGAAGAAAATAAGGACTAGGAAAGTTAATAACTTGCCAAGAATCACACAAGGAATGTGTAGTATTTAAACCCATTCAATATATGGCATTCAAACCTTCAAATTCTGGGTACTTCTGTATCTCTCTCTAGGTTAAAATGAAGCTAGGACATCTCATAAAGCCAAACTATTGTTTAGATTTGACAGAAGGACCAACATCATATAAAGCAATGAATGTACTGATTCCTCCCTGCAGAAGGCATCGTCATGATGTTTACCTTGCAGAGTGTCATTCCTGGAGCTGAAATGCTCTGTACATGAGAAAAGTCAAGGATCTCTGACATTAAGAGCTGCCTAGGCCGGGCATGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATTACCGGAGCCCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATGAAAAATTAACCAGGCATAGTGGTGGTGCGTGCTTGTGTTCCCAGCTCCTCGGGAGGTAGAGGCGTGAGACTTGTTTGAACTTGCTTGAAAATGTGGAGGTTGCAGTGAGCCAAGATCCCACCACTGCACTCCAGCCTCGGTGACAGAGTGAGGCTATGTCACTTACACACACACACCCCCGAGCTTCCTTATAGCTGTGTAGTGGTAGGGCTCAACTCTGGAATCATATGTCAGGAGAGTAATATGGAATAATAGTAGCCTGAAATGTGATCCCTTGACGGATCTTTAAGCAATAGGCCTTTCCTACTTTTTCTTACCCTTATGGTTTTGGATTTAACCTCATTCTCCCTTCTTGGTGTTTGTTCTTGACCTCAGCCTCTTTCTACTCTTTGTAGACATAAATGAATGCACAGATTTTGTAGATGTCCCTTGTAGCCACTTCTGCAACAATTTCATTGGTGGTTACTTCTGCTCCTGCCCCCCGGAATATTTCCTCCATGATGACATGAAGAATTGCGGAGGTGAGCTTGGTGTTAAGAGGGTTGCATGTTCCCTGGGATTTGGAATGGCTGAGGCCTCAGAAAGGGCTTTGTCCACCCTTCCAACTTCGATTAGGCCAAGCCTTCATTTGGCACTTCTTTTTTATTTTAGAATTTATTTATTTATGTATTATTTTTAATAATTTCAATAGTTTTGGGGGTACTGGTGTTTTTGGTTACATGGATGAGTTCCTTAGTGGTCAATTCTGAGATTTTAGTGCACTTGTTACTTGAGCGGTGTACACTATACCCAGTGTGTAGTTTTCTCGCCCCTGTTTCAACCTCCTCCCACGTTGAGTCCCCAGAGTCCATTATATCACTCTGTATTGGCATCTATTCTTAGTTACTCATAAGCTGAGATGAAGCCACAAGAAGGAGGAAGATAAGACTATAGGGTAAAGTTAGTTAATTGGATAAGAGAGATAGATGCCTGTAAAGGGTCTACTGGGGGCTGTTCATAACCAGAAAGGCTCCATCCTAAGCAAAGTGATGGAAACCTAATAGGGATTGGGTATTCCTACTGATACGTATTGCACGTGTAATTGCTCTATCCCTCCAGTTAGGGCAGGGATCTCAGGTTAGTTTGAATGCAGGACTGTCAGTTTCTGAGAGAAGGAATCATAGAATAGTGCAGGAATTCCTTTGCTTGACCCTGTATTTGATTCTCCCTTTCTCTTTTTCTCTGTTAGTTAATTGCAGTGGGGATGTATTCACTGCACTGATTGGGGAGATTGCAAGTCCCAATTATCCCAAACCATATCCAGAGAACTCAAGGTGTGAATACCAGATCCGGTTGGAGAAAGGGTTCCAAGTGGTGGTGACCTTGCGGAGAGAAGATTTTGATGTGGAAGCAGCTGACTCAGCGGGAAACTGCCTTGACAGTTTAGTTGTGCGTGATGGTTGATTAATACCCCACCCTTAACTTACACAGAGAGATCTCTCCCTGAAGACAAATTTTTTTTTCATACAGCATCTTTCTCTGTTGCTCAAGCTGGAGTGCAGTGGTGCAATCACAGCTCACTGTAGCCTTGATCTCTTGGGCTCAAGCAAGCGTCCCACCTCAGCCTCCTGAGTAGCTGGGCCCACAGACGTGTGTCATCAAACCCAGCTAATATTTTTATTGTTATTCTTTTTTTTTTTACAGAGATGGGGTTTTGCTATGTTGCTCAGGATAGCCTGAAACTCCTAGCCTCAAGCAATGCTCCCACCTCGGCCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGCACTCAGCCTGAAGATAAAATTATCTTTTCTCCTGACCCTTATTTTCTTCTTATTTTATGTGACATTTAATGCCTCTTTTATTTGTATCTCCCACTTCCCAATTTTACCTCTTCCCTTTAGTTCTTTCCCTCTTCTGATTTCATCATTTTGTTCAGTTTGTTGCAGGAGATCGGCAATTTGGTCCTTACTGTGGTCATGGATTCCCTGGGCCTCTAAATATTGAAACCAAGAGTAATGCTCTTGATATCATCTTCCAAACTGATCTAACAGGGCAAAAAAAGGGCTGGAAACTTCGCTATCATGGAGATCGTGAGTAACTTAGAAGTGCCTCTTTGGTTGGTGATACCAAAGTCCCCAAACAATGTGGGATCAAAGCAGGTAGATGATCCAGGCACACTGGAAGCACCTGTGATCTCAGCTACCGAGGGAGGCTGAGGCAGGAGGATCCCTTGAGCCCAGGAAGTAGGAGTTTGAGTCCACTCTGGGCAACAGAGCAAAACCTTGTCTCTAAAACAAAACAAAAACAAAGCAACAATAATTTAAAAAACAGATAGATTGTTGTTCTGATAGAATCCTGAGATACTTCACTTCTTCAGGAAAATCTAAACCAGTCAACGGTTGCTAGAAATGCCTCAACCTCTAGTAATCCTTTAACTAGACCTGAGACTGCAGACAGCTTGCGGGTGGTTAGTTGGTAATGCCATATGATTTTAGACATCTGCTGTATTGGAATGTTAAGCATCAGGATTGAGGACAACTGGACGATTTTAGAAAGTGTGAGAATGATGTAAATAGAATGAGAGTCTTCAACTATTTAGTAATTTTTTCCTCCTGTCCCAACTTCTGTTCTTTCAAGCAATGCCCTGCCCTAAGGAAGACACTCCCAATTCTGTTTGGGAGCCTGCGAAGGCAAAATATGTCTTTAGAGATGTGGTGCAGATAACCTGTCTGGATGGGTTTGAAGTTGTGGAGGTAAAGTACCACCTTGGCTTCTCCCCAGTCCCTGGCCCCAGATCAGGATGAGCGGACTGAAATTGTCCAGTTGTTTACCCAATGTATGTGTGTGATCAAGGTATAACACCTTTCCCATAAACACAACAGCTTAAGATCTGTAGTTCTCCCTTGTGAGTCATGGAGCTGCCTGGCCAGCTTGGCATTCTCTCTGCCTTCAGTCTTCTTGAGGAAGGGGAGTTGACACGTTGGGGCAAAGCTTTCTGTCAGCCTCATCTCCTGGGTGCTTTAGGTCTGCTAAGATGTTCCCAAGCTTCTTGTGGTGAGGACTCCTCATTGATCCAAGGCCAGAGATCAATTCCAGTTTTGATTTTGGTTTCCCATATCTCTCTTCAGAAATAAGTGGTGATGTTTATTATTCTCCAGGGACGTGTTGGTGCAACATCTTTCTATTCGACTTGTCAAAGCAATGGAAAGTGGAGTAATTCCAAACTGAAATGTCAACGTATGTGTCTCTTCAAAGTGGAAGTCTTTCTTTTTCTCTCAGAGAGAATGGAAAGATCAGCACATCAAAATTCAAATGCATGGTTTCCTCTTAGGCATGTGAGGGAGTGGGTTGGGTTTTTGAAGGGAAGCCAGTCATGGAAGCTTTTCTAGTCCCAGCCCCGCATCTGGTCCCAGGCCAACTAGATCGGCATGTTTCTTTCCAAGAAAGGGGCTATGGGATAGGTCGAGTTAGTAGCCCCACGTGGGTGCATTTGTGGCTTCCACTGGGCCTTCACCAACCACTGAGAACCAGGCTCTTCACTACGGCTTTCATGGGGCCATCTGAATTGGCATCTCAGCGGGTGAGAGAGCTGAGAGATGCCAGTTGGGGAGGATGGCCACAGAGAGGCTGGTGTGGGGAGGTTCATCCCAGGTGTGCCTGTGGATATGGGGTGGGGAAGCAGTGAGGATGAACCTGGCCCCATGACTCTTCCTTGGAGGAAGTGGCTGTCCTGACCATCGCTCTCCTTCCTTCGTCTGGTAGCTGTGGACTGTGGCATTCCTGAATCCATTGAGAATGGTAAAGTTGAAGACCCAGAGAGCACTTTGTTTGGTTCTGTCATCCGCTACACTTGTGAGGAGCCATATTACTACATGGAAAATGGAGGAGGTGGTAGGTTTCTTCTACTGGAGAAGAGAGAGAGAGAGTGAGAAGGTGTTGGAGGGTGGATAGCATAATCTGTGCCAGAGACAGAGTTTGGAGACAAATGAAGGCGATAGGACAGACATTGTTCATCCCCTTGGCTTCGTCCAAAGATACAGTTTTCATCTGGAGCAGGGCAAGTTCAGGGGAGCATCAGCCTCAGGGAATCATAGAGGTCACCAACTGAGTTCACAGCTGCAGCAGGAATTCCCCTACAACATCCATTTCATGGGATTACCCACCTTTTGACCAGTTATTTCATGTAAAACCCACAGGAGCAATGCCTTCAGCTTTAAGCCACCAAACTACACTGACTGGCTTTCTTGATGTAGAGGCTTTGGTCATGCTAGGTGCAGGGCTGAATGAGACCCTAATACGTTCTCTGCATTGCTCTGTATTTATTTCGCCACTTTCCCGATGCCTTCTTTCCTTCTGCTTTGGAGATGTTCCCTTTGTCTCCCTGGCAGGCTAGAGGCCTGAGGGATTGTTTGGAGGAAGATATTTTTTTTCTGGCTGATTTAATCTGATTTACTACTTGAATCCTAGACGAGCTGAGGTTCTGAAGGAACGGGGCAGGGTGTTGGGGTCGGAGGGGGGAATGGAAGAAGGAAGATGTGGTGGTGAGTGTGGCCTGTGTTCTCTGTGCTATTCCAGGGGAGTATCACTGTGCTGGTAACGGGAGCTGGGTGAATGAGGTGCTGGGCCCGGAGCTGCCGAAATGTGTTCCAGGTAAGGAGGGCTGAGGCTTGGGGAGAGATGATAGCCATGGGTGACTGGGAGTCACCTTCTGAAAGCAACTGTAATCCTCTTGGGAAAGGACTGAACAGTGACCTGCCAGAGTCCAGCTCAGTGAGGTGGCAGTATCACTGTGCCGTGGGCTGCCAGGGCCGTGGGGAACCTCCTCAGCCGCACTGAAGCCAGGCCAACTGGAAGGAAATAGAAACGTCAGCCAGCGACAGTTGGTGTCTGGTAATGTAGCTGCAGTGAGAAGATACAGAACTGCTAAAAACAGGGCCTGAAAGCTGAGAGTGTGTGAGTAATCAACACTCAGAAACAAGTCTAGCTAAATAGCCTAGTTATTATATTAAAAGTTTATAGGGCAGCAAGATATAGAGGAATTCAAAGAATGAGGAAGATAAGAGTTGGGTAGCAGAAGGCTGAGGCAAATCCAATAGGATAATAACCATCCTGGGTGGTACTGAAAGCTGAAGACTGAGCTGATTTGTTGCATTTATTATCTCATTCGTGTCCGTATAACAGCCCTGTGAGCTAGGTGTCATTGGTCTTATCTGACCAATGTCAAATGTGAATGGGTGGGGTGCAAGTTCACAGAGTTAGCAAGTGGCAAAGGCAGGCTTTGAGCCCAGGTCTGTCTAAGTTCACAGCCCATTGTGCTCAACTTGGAGTCCCTCCAGGCTGTCTAGTAAGGGATTTAAGTAAGCAGCTTCACTTGAATTCAGTTATTAGTATAACTGAATGGTAATGGCACCAGTCACTGGGAGTGAGAGGTCAGGGCCAAAGAAGGGACCCCTCTCTACTTCCTAGGCTGACCTGTGGTTTACTAGGAGGGACTCAGGTGCAACTAGGACTCCAGTAAAGAAGGTGATTAAAGTTTGATCTGGGCATCTGAAGAAGGCAGAAATCTTTCCTCCTCCACCATCTGTGTGAGAAAAGGGTTTCCAGCACTGGCTCTTGATTGGGCACCGGCCTCATGTGCCGAGTTGGGAGGTGCAAAGGGGACCCCTGCCTCCAGGGGGGCTGTGGGTCGCACTGTGGATAGTGTGAGGCATTAGTGCATCTGGACTCAGTGATTCACACACTGCCTCCGTTTAACTGAGCTCTCCCATGAGCCAGCTTATGACATCGGCAAAGCGGGATGTTTAGGTAAGGCCAGAGTGGGTCAGGTATTGAGATTGTTGACCAAATAGGGTTGACTATTTTGTACTAGAGAATCCTGCAACCTAGCAGGTAACATTATGTGAGTGGTTGGAGGATTTGCAGGAAGCCAGCATCATTTCTTCCTCCTTCCCTGTGTTGTTTTATTCCTTCCTAGTCTGTGGAGTCCCCAGAGAACCCTTTGAAGAAAAACAGAGGATAATTGGAGGATCCGATGCAGATATTAAAAACTTCCCCTGGCAAGTCTTCTTTGACAACCCATGGGCTGGTGGAGCGCTCATTAATGAGTACTGGGTGCTGACGGCTGCTCATGTTGTGGAGGGAAACAGGGAGCCAACAATGTATGTTGGGTCCACCTCAGTGCAGACCTCACGGCTGGCAAAATCCAAGATGCTCACTCCTGAGCATGTGTTTATTCATCCGGGATGGAAGCTGCTGGAAGTCCCAGAAGGACGAACCAATTTTGATAATGACATTGCACTGGTGCGGCTGAAAGACCCAGTGAAAATGGGACCCACCGTCTCTCCCATCTGCCTACCAGGCACCTCTTCCGACTACAACCTCATGGATGGGGACCTGGGACTGATCTCAGGCTGGGGCCGAACAGAGAAGAGAGATCGTGCTGTTCGCCTCAAGGCGGCAAGGTTACCTGTAGCTCCTTTAAGAAAATGCAAAGAAGTGAAAGTGGAGAAACCCACAGCAGATGCAGAGGCCTATGTTTTCACTCCTAACATGATCTGTGCTGGAGGAGAGAAGGGCATGGATAGCTGTAAAGGGGACAGTGGTGGGGCCTTTGCTGTACAGGATCCCAATGACAAGACCAAATTCTACGCAGCTGGCCTGGTGTCCTGGGGGCCCCAGTGTGGGACCTATGGGCTCTACACACGGGTAAAGAACTATGTTGACTGGATAATGAAGACTATGCAGGAAAATAGCACCCCCCGTGAGGACTAATCCAGATACATCCCACCAGCCTCTCCAAGGGTGGTGACCAATGCATTACCTTCTGTTCCTTATGATATTCTCATTATTTCATCATGACTGAAAGAAGACACGAGCGAATGATTTAAATAGAACTTGATTGTTGAGACGCCTTGCTAGAGGTAGAGTTTGATCATAGAATTGTGCTGGTCATACATTTGTGGTCTGACTCCTTGGGGTCCTTTCCCCGGAGTACCTATTGTAGATAACACTATGGGTGGGGCACTCCTTTCTTGCACTATTCCACAGGGATACCTTAATTCTTTGTTTCCTCTTTACCTGTTCAAAATTCCATTTACTTGATCATTCTCAGTATCCACTGTCTATGTACAATAAAGGATGTTTATAAGCAAATTTTGTGTGACTTACCTCATTCCACACCAAACCCTCAGAATTATAGAAGGGGAATGGGATGAGAAGGCTGTTATGTCACTGAAATTGGGCATCCAGCAACTAATATTTAATTTAATTGTCACGAAAACAGGGAATTCAGCTTTTCTTCTCTCTTCCAAATGAGATTTACTGAATATTGTGGGTTAGTATGAAGATCGCCAGTGTAAGGCATCACATTCTGCTTTTGAAACTCATTAATATTTACCTGGCCAAAAAAAAAAAAAAAAAAAAAAGAAGAAAAGAAAAATAAGAAAAAAAAGAAGCTCATTAAATGTCATGTGGTGCGTGGCTCACACCTGTGATCCCAACACTTTGGGAGGCAGGGGTGGGAGGATTGCTTGAGCCCAGGGATTCAAGACCAGTGTGAGCAACATAGGGAGACCCTGTCTCTACAAAAATAAAAAATAAAAATTAGCTAGGCATGATGGTGCGTGCCTTAGTCCCAGCTACTCAGGAGGCTGAGTTGGGAGGATCGCTTGAGCCCAGGAGGTCAAGGTTGCAGTGATCATGCCACTGTACTCCAGCCTGGGCAACCAGAGTGAGACATTATCTGGAACAAAGCAAAATAAAAAAACCCCACCTCATTCAGAAATCCATGTACAATAGTTTGAGTTGGCTGTTTAAGATCTTCTTTAAGTAGAAATTGTTTCAATATGTGAACGGAAAGTTAATTTTCCTCTAATACTCATTGTATCATGCAATATTATGACAACAAAAAAGAAAAACTAAAGAAATTGAGCATGCTCTTGTCTGCTTTCCTGGTGGTTTTAATCAATTTGTGACAATGTTTTCATTAGACTGAACTCTGTACCAAGATGACATAGCAGAAAATCTCGGTAAGGATGGACCCCAAAACTCTCCCTTCTATTTTCTAGGGGAAGGAAAAGAAAAGATTCCTCTTCCAAAAGAATGATTAGTGATGAGAAATGACTACAGAATAGAGACTTAGCATTTTAAAAACTGAGGACAGGACAACTATCTTAGGACAGCGGTTGCCCTAACAGGGCGTCTTAGGAAAGCGGAGGTCTGAGAGGAAGAGCTGAGGGGGAATCTGACCTATTTGATGTGACACGTGGCTTTCAGGAGGGCAGTTTTTACTAGAAGCCAAAAAAGGTTGGTTTGGGCCCATCAAGAATGGACTTTGATATTCCATAGACCAAGAGGGCTAAATTCAACAGTTGACCTTAGACCGCAGGGTAAACGTGATGAGGTAACCAGAGGAACTCTAATTGAAGGGCCTGAAGAATTGAAGGGAATTACAACAGGGAGTCCCTGGGAGGATTATATGGTCAACCAAGCAGCATAAAGTCACTGTGTCACTCCTGAACTGTATGCCTCATAGCCACCTCCTCACCCTTCCTGTCATTGCAGGAGCAATGGAGTTGACAGTGTGCCCTGGGTGAGAGTGTTTCCGTGAGAGGAGGATTCTTCTAGAGATAAAAAGGCATTGGAGGAATATTAAGATTTAGAAACATGGTCTGTGAAAGGGATATTGTTCTTCTTTTTTTATACTTGGGGCAATAGCAAAAAATTAACCTGGAATCTGACAAGTAACAGAAAAAGGAAGTTCATCCCTCTCGGAGAATCACCAGTCTATTTGGGTTCTGCCCTTGCTGATGGGCTGAGGTATTGGTGAAGAATTTCCCTCTTTGCTGCCACCTTGTACGGCATGACGGGAATGGGCTTTGCATCGTTGACTGTGCTGCAAGGTCATTTCTCTGGGTGAATGGCAGGGAGAAGACCTAAATGAATCATGATCAGAGACTTCAGAGCTGGGAAGAGCTTGTCATCAGGTCCTAGAGGGGCTAGAAAGTCATTCATTGTGTTTAAAGGGTATCCATCGTAGTACCTTGCAAGTTACTTGGGAACATATGTCCGCTTCATCTGAAACTCAGGAAAAGAGTTAGCTTTTTGAAGAAGGTGAATTGTCACTTTTCTTTGGTCAGAAGAAAATGGACTGG 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| Title of study | Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis |
| Abstract of study | AIM: Oral cancer may become advanced because of delay in diagnosis. In order to promote oral cancer screening, simple and highly reliable screening methods that can be implemented at general dental clinics are required. Herein we investigated differential salivary gene expression between oral squamous cell carcinoma (OSCC) patients and healthy volunteers (HV) to identify new biomarkers for OSCC detection.MATERIALS AND METHODS: Candidate genes were selected by microarrays, nuclear undecaprenyl pyrophosphate synthase 1 (NUS1) and reticulocalbin 1 (RCN1) were selected for further investigation. We used real-time quantitative reverse transcription PCR (qRT-PCR) to determine NUS1 and RCN1 expression levels in saliva and tissues.RESULTS: qRT-PCR analysis of clinical samples revealed that OSCC patients had significantly higher expression of salivary NUS1 and RCN1 than HV.CONCLUSION: A combination of NUS1 and RCN1 accurately distinguished patients from controls, and this combination can be implemented as a screening test for OSCC. |