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SAL_24874 details
Primary information
SALIDSAL_24874
Biomarker namehsa-miR-339-3p
Biomarker TypeDiagnostic
Sampling MethodThis study involved two analysis groups: (1) a case-control comparison between 13 former professional American football athletes and 18 age/gender-matched controls (ages 46-89 years); and (2) a cross-sectional study of 310 individuals (ages 7 to 39 years)
Collection MethodSaliva was collected from each participant in a non-fasting state after oral tap-water rinse, using OraCollect Swabs
Analysis MethodNA
Collection SiteSaliva
Disease CategoryNeurological Disorder
Disease/ConditionCumulative Concussion
Disease SubtypeNA
Fold Change/ Concentration2.7
Up/DownregulatedUpregulated
ExosomalExosomal
OrganismHomo sapiens
PMID33092191
Year of Publication2020
Biomarker IDhsa-miR-339-3p
Biomarker CategorymiRNA
SequenceUGAGCGCCUCGACGACAGAGCCG
Title of studySaliva microRNA Biomarkers of Cumulative Concussion
Abstract of studyRecurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (n = 230), a single concussion (n = 56), or recurrent concussions (n = 24). There was no difference in neurocognitive performance between the former professional athletes and their peers, or among younger individuals with varying concussion exposures. However, younger individuals without prior concussion outperformed peers with prior concussion on three balance assessments. Twenty salivary miRNAs differed (adj. p < 0.05) between former professional athletes and their peers. Two of these (miR-28-3p and miR-339-3p) demonstrated relationships (p < 0.05) with the number of prior concussions reported by younger individuals. miR-28-3p and miR-339-5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects.