| Primary information |
|---|
| SALID | SAL_17089 |
| Biomarker name | L-Tryptophan [HMDB0000929] |
| Biomarker Type | NA |
| Sampling Method | Adult (>18 years old); Gender-both |
| Collection Method | NA |
| Analysis Method | NA |
| Collection Site | Saliva |
| Disease Category | Healthy |
| Disease/Condition | Healthy |
| Disease Subtype | NA |
| Fold Change/ Concentration | 0.5 +/- 0.5 uM |
| Up/Downregulated | NA |
| Exosomal | NA |
| Organism | Homo sapiens |
| PMID | 15995595 |
| Year of Publication | 2005 |
| Biomarker ID | 6305 |
| Biomarker Category | Metabolite |
| Sequence | C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N |
| Title of study | [Metabolism of tryptophan via the kynurenine pathway in saliva] |
| Abstract of study | In this review, the role of the kynurenine pathway enzymes TDO (tryptophan 2,3 dioxygenase) and IDO (indoleamine 2,3 -dioxygenase) as well as the properties of the metabolites of kynurenine degradation present in human saliva described. The implications of these metabolites in the pathomechanism of tissue and organs dysfunction are demonstrated. The authors also describe at length the role of saliva kynurenine derivatives in the onset and development of periodontal disease in humans. |