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SAL_17081 details
Primary information
SALIDSAL_17081
Biomarker nameCholesterol [HMDB0000067]
Biomarker TypeNA
Sampling MethodAdult (>18 years old); Gender-both
Collection MethodNA
Analysis MethodNA
Collection SiteSaliva
Disease CategoryHealthy
Disease/ConditionHealthy
Disease SubtypeNA
Fold Change/ Concentration<1.00 uM
Up/DownregulatedNA
ExosomalNA
OrganismHomo sapiens
PMID15179829
Year of Publication2004
Biomarker ID5997
Biomarker CategoryMetabolite
SequenceC[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
Title of study[Levels of unified metabolites and thyroid hormones in blood and oral fluid of children with minimal brain dysfunction]
Abstract of studyMinimal brain dysfunctions in children with various perinatal complications are accompanied by metabolic imbalance manifested by decreased total protein content, the tendency to reduced triglycerides, increased cholesterol concentrations in the oral fluid, the trend to hypoproteinaemia, hypoglycaemia, hypotriglyceridaemia. The most significant changes in the redox systems alpha-ketoglutarate-glutamate, oxaloacetate-malate, pyruvate-lactate, dioxyacetone phosphate-alpha-glycerophosphate in biological fluids were revealed in cases of antenatal alcoholisation. A certain correlation was found between anemia in pregnant women and hypothyroidal background in children. In addition, a high level of free and total thyroxine, that of total triiodthyronine were found in the oral fluid. Hypophysis--thyroid dysregulation in children with minimal brain dysfunction associated with gestosis in their mothers during pregnancy, was manifested by decreased content of total and free T4 and T3 in blood serum and increased level of the thyroid-stimulating hormone.