| Primary information |
|---|
| SALID | SAL_17005 |
| Biomarker name | p-Hydroxyphenylacetic acid [HMDB0000020] |
| Biomarker Type | NA |
| Sampling Method | Adult (>18 years old); Gender-both |
| Collection Method | NA |
| Analysis Method | NA |
| Collection Site | Saliva |
| Disease Category | Healthy |
| Disease/Condition | Healthy |
| Disease Subtype | NA |
| Fold Change/ Concentration | 7.0 (2.0-10.0) uM |
| Up/Downregulated | NA |
| Exosomal | NA |
| Organism | Homo sapiens |
| PMID | 11997029 |
| Year of Publication | 2002 |
| Biomarker ID | 127 |
| Biomarker Category | Metabolite |
| Sequence | C1=CC(=CC=C1CC(=O)O)O |
| Title of study | The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach |
| Abstract of study | Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2-10 microM) and nitrite (60-300 microM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions. These results suggest that salivary HPA is nitrated to NO2HPA when saliva is swallowed into the stomach. |