| Primary information |
|---|
| SALID | SAL_11902 |
| Biomarker name | C-reactive protein |
| Biomarker Type | Diagnostic |
| Sampling Method | A total of six saliva samples were collected via passive drool from each participant using polypropylene collection tubes |
| Collection Method | Participants were asked to provide 2 ml whole saliva at each time point. |
| Analysis Method | ELISA and CRP assay |
| Collection Site | Saliva |
| Disease Category | Stress |
| Disease/Condition | Stress |
| Disease Subtype | NA |
| Fold Change/ Concentration | NA |
| Up/Downregulated | Upregulated |
| Exosomal | NA |
| Organism | Homo sapiens |
| PMID | 32253920 |
| Year of Publication | 2020 |
| Biomarker ID | P02741 |
| Biomarker Category | Protein |
| Sequence | MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP |
| Title of study | C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African-Americans |
| Abstract of study | Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based social-evaluative stressor task. Six saliva samples taken before, during and after were assayed for salivary CRP. DBS measurements of CRP were taken alongside saliva at the first and last collection. Results: Salivary and DBS CRP were modestly positively associated with one another at baseline, and only salivary CRP increased in response to the stressor task. Conclusion: Noninvasive measures of CRP reactivity may be only moderately related to one another in stress reactivity contexts. |