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SAL_10281 details
Primary information
SALIDSAL_10281
Biomarker nameSalivary adiponectin
Biomarker TypeDiagnostic
Sampling MethodSalivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19).
Collection MethodUnstimulated whole saliva was collected by drooling before the oral examination.
Analysis MethodELISA
Collection SiteWhole Saliva
Disease CategoryAutoimmune Disorder
Disease/ConditionSjogren's Syndrome
Disease SubtypeNA
Fold Change/ ConcentrationNA
Up/Downregulatedupregulated
ExosomalNA
OrganismHomo sapiens
PMID30030617
Year of Publication2018
Biomarker IDQ15848
Biomarker CategoryProtein
SequenceMLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDGTPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLYHDTN
Title of studySalivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren's syndrome: a pilot study
Abstract of studyOBJECTIVES: To evaluate salivary adiponectin and adenosine deaminase (ADA) in women suffering from Sjögren's syndrome (SS).METHODS: Salivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19). A clinical history was made for each patient, patients were examined clinically, and xerostomia inventory (XI) was performed.RESULTS: Salivary adiponectin corrected by total protein was higher in patients with SS than in healthy individuals (P < 0.05) or patients with non-SS sicca (P < 0.01) and correlated with XI (r = 0.555; P < 0.05). Salivary ADA was higher in patients with SS and non-SS sicca compared to controls (P < 0.05 in both cases).CONCLUSION: The results of the present study indicate that adiponectin and ADA are increased in the saliva of patients with SS.CLINICAL RELEVANCE: Salivary adiponectin corrected by total protein can be a potential biomarker of SS.TRIAL REGISTRATION: NCT03156569.