Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2576Profilin and bacterial rRNA respectively (not found in humans)

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BacteriaNANAProteinNaturalNAToll-like receptor 12 (TLR12)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2576Profilin and bacterial rRNA respectively (not found in humans)

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BacteriaNANAProteinNaturalNAToll-like receptor 12 (TLR12)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2577Profilin and bacterial rRNA respectively (not found in humans)

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BacteriaNANAProteinNaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2577Profilin and bacterial rRNA respectively (not found in humans)

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BacteriaNANAProteinNaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2585rBanLec

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E. coli(Bacteria)NANANASyntheticImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeritoneal macrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2585rBanLec

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E. coli(Bacteria)NANANASyntheticImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeritoneal macrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2586rBanLec

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E. coli(Bacteria)NANANASyntheticImmunostimulantcluster of differentiation 4 (CD4)Pattern recognition receptor (PRR)MicePeritoneal macrophagesNAP06332.fastaP06332457production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2586rBanLec

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E. coli(Bacteria)NANANASyntheticImmunostimulantcluster of differentiation 4 (CD4)Pattern recognition receptor (PRR)MicePeritoneal macrophagesNAP06332.fastaP06332457production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2590RNA

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Streptococcus (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNA23S rRNA motif,Q9NR97.fastaQ9NR971041NANA290428602017Pubchem_assay
PRRID_2590RNA

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Streptococcus (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNA23S rRNA motif,Q9NR97.fastaQ9NR971041NANA290428602017Pubchem_assay
PRRID_2593RNA

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Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceDendritic cellsLRRQ99MB1.fastaQ99MB1905This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2593RNA

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Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceDendritic cellsLRRQ99MB1.fastaQ99MB1905This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2594RNA

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Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceDendritic cellsLRRP58681.fastaP586811050This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2594RNA

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Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceDendritic cellsLRRP58681.fastaP586811050This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2619single-stranded RNA

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Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290389562017Pubchem_assay
PRRID_2619single-stranded RNA

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Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290389562017Pubchem_assay
PRRID_2620single-stranded RNA

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Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA290389562017Pubchem_assay
PRRID_2620single-stranded RNA

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Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA290389562017Pubchem_assay
PRRID_2629single-stranded RNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2629single-stranded RNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2630single-stranded RNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2630single-stranded RNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2645TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2645TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2646TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRHumanNANAQ8WXI8.fastaQ8WXI8215Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2646TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRHumanNANAQ8WXI8.fastaQ8WXI8215Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2647TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2647TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2648TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2648TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2657trehalose 6,6′-dimycolate

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Mycobacteria (Bacteria)CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)ONAGlycolipidNaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay
PRRID_2657trehalose 6,6′-dimycolate

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Mycobacteria (Bacteria)CCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)C(=O)OCC2C(C(C(C(O2)OC3C(C(C(C(O3)COC(=O)C(CCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O)ONAGlycolipidNaturalNACLEC4EC type Lectin (CTL/CLR)HumanNAC-Type Lectin domain family 4, member EQ9ULY5.fastaQ9ULY5219NANA290662552017Pubchem_assay
PRRID_2658Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA292639322017Pubchem_assay
PRRID_2658Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA292639322017Pubchem_assay
PRRID_2659Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2659Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2660Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalInduce IL-Ôòæ production in human tonsillar B cellsToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA290283692017Pubchem_assay
PRRID_2660Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalInduce IL-Ôòæ production in human tonsillar B cellsToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA290283692017Pubchem_assay
PRRID_2661Unknown

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BacteriaNANAProteinNaturalNATRl OToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2661Unknown

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BacteriaNANAProteinNaturalNATRl OToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2662Unknown (uropathogenic bacteria)

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BacteriaNANAProteinNaturalNAToll-like receptor (TLRll)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2662Unknown (uropathogenic bacteria)

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BacteriaNANAProteinNaturalNAToll-like receptor (TLRll)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2663Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292639322017Pubchem_assay
PRRID_2663Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA292639322017Pubchem_assay
PRRID_2664Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNANAQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2664Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNANAQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2665Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2665Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290662552017Pubchem_assay
PRRID_2666Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2666Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2667Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2667Unmethylated CpG DNA

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BacteriaNANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290283692017Pubchem_assay
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2669Unmethylated CpG DNA

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BacteriaNANAProteinNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2669Unmethylated CpG DNA

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BacteriaNANAProteinNaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2680Uropathogenic E. coli

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E. coli(Bacteria)NANANANaturalNAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292639322017NA
PRRID_2680Uropathogenic E. coli

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E. coli(Bacteria)NANANANaturalNAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292639322017NA
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_27001,3 beta glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNAb-1,3-glucan recognition proteinsGastrin-releasing peptide receptor (GRP)NANANANANANANANA290322412018NA
PRRID_27001,3 beta glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNAb-1,3-glucan recognition proteinsGastrin-releasing peptide receptor (GRP)NANANANANANANANA290322412018NA
PRRID_2732Pseudomonas aeruginosa

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Gram negative Bacteria (Bacteria)NANAPeptidoglycanNaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumancytoplasmCARDQ9Y239.fastaQ9Y239953via outer membrane vesicles (OMVs)NA293533102018Pubchem_assay
PRRID_2732Pseudomonas aeruginosa

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Gram negative Bacteria (Bacteria)NANAPeptidoglycanNaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumancytoplasmCARDQ9Y239.fastaQ9Y239953via outer membrane vesicles (OMVs)NA293533102018Pubchem_assay