Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1997diacylated and triacylated lipopeptides

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NANANANANaturalNAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNANAQ15399.fastaQ15399786NANA290662552017Pubchem_assay
PRRID_1997diacylated and triacylated lipopeptides

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NANANANANaturalNAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanNANAQ15399.fastaQ15399786NANA290662552017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_2000diaminopimelic acid (DAP)

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Gram-negative and Gram-positive bacteriaC(CC(C(=O)O)N)CC(C(=O)O)NNAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_2000diaminopimelic acid (DAP)

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Gram-negative and Gram-positive bacteriaC(CC(C(=O)O)N)CC(C(=O)O)NNAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_2001DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154Activate NF-KBNA280491422017Pubchem_assay
PRRID_2001DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154Activate NF-KBNA280491422017Pubchem_assay
PRRID_2002DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisAIM2Pattern recognition receptor (PRR)HumanNANAO14862.fastaO14862343Activate NF-KBNA280491422017Pubchem_assay
PRRID_2002DNA

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All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisAIM2Pattern recognition receptor (PRR)HumanNANAO14862.fastaO14862343Activate NF-KBNA280491422017Pubchem_assay
PRRID_2004DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154NANA289610192017Pubchem_assay
PRRID_2004DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanDendritic cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154NANA289610192017Pubchem_assay
PRRID_2005DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA289610192017Pubchem_assay
PRRID_2005DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA289610192017Pubchem_assay
PRRID_2006DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2006DNA

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NANANANucleic AcidNaturalinduce the secretion of IL-12, IL-8, and IFN-α in human dendritic cells.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humandendritic cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2007dsRNA

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VirusNANANucleic AcidNaturalviral infectionMelanoma differentiation -associated gene 5 (MDA5)Pattern recognition receptor (PRR)Humanmitochondrial outer membrane(CARDs), a DEAD/H box RNA helicase domain, and a C-terminal domain (CTD).Q53TB6.fastaQ53TB6435NANA290696502017Pubchem_assay
PRRID_2007dsRNA

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VirusNANANucleic AcidNaturalviral infectionMelanoma differentiation -associated gene 5 (MDA5)Pattern recognition receptor (PRR)Humanmitochondrial outer membrane(CARDs), a DEAD/H box RNA helicase domain, and a C-terminal domain (CTD).Q53TB6.fastaQ53TB6435NANA290696502017Pubchem_assay
PRRID_2008dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904NANA290662552017Pubchem_assay
PRRID_2008dsRNA

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VirusNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanNANAO15455.fastaO15455904NANA290662552017Pubchem_assay
PRRID_2012dsRNA

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flu virus, SeV and bacteriaNANANucleic AcidNaturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2012dsRNA

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flu virus, SeV and bacteriaNANANucleic AcidNaturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2020Envelope F protein

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NANANANANaturalinduce proinflammatory cytokine production through NF-KB signaling, Activates the innate immune response by driving NF-κB-mediated cytokine expression, Activate macrophages through MyD88 and TRAF6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman PBMCsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2020Envelope F protein

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NANANANANaturalinduce proinflammatory cytokine production through NF-KB signaling, Activates the innate immune response by driving NF-κB-mediated cytokine expression, Activate macrophages through MyD88 and TRAF6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHuman PBMCsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290283692017Pubchem_assay
PRRID_2021F2M2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2021F2M2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2022F2Pal10

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2022F2Pal10

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2023F2Pal12

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2023F2Pal12

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2024F2Pal16

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2024F2Pal16

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2032Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the biosynthesis of leukotriene B4 in human neutrophils and monocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNeutrophils and monocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2032Fibronectin

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Endogenous (others)MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP2386GlycoproteinNaturalInduce the biosynthesis of leukotriene B4 in human neutrophils and monocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNeutrophils and monocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay
PRRID_2034FlaB1, FlaB2 or FlaB3

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T. pallidum (others)NANAPattern-associated molecular patterns (PAMPs)Naturalcapable of triggering MMP-9 and MMP-13 expression in humanToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAELISA289825392017Pubchem_assay
PRRID_2034FlaB1, FlaB2 or FlaB3

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T. pallidum (others)NANAPattern-associated molecular patterns (PAMPs)Naturalcapable of triggering MMP-9 and MMP-13 expression in humanToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAELISA289825392017Pubchem_assay
PRRID_2035Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNANAO60602.fastaO60602858NANA290662552017Pubchem_assay
PRRID_2035Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNANAO60602.fastaO60602858NANA290662552017Pubchem_assay
PRRID_2037Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInduce secretion of cytokines, chemokines and co-stimulatory molecules from T cellsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA290283692017Pubchem_assay
PRRID_2037Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInduce secretion of cytokines, chemokines and co-stimulatory molecules from T cellsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA290283692017Pubchem_assay
PRRID_2038Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalBacterial infectionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA289828472017Pubchem_assay
PRRID_2038Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalBacterial infectionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA289828472017Pubchem_assay
PRRID_2039Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMembraneD0 domainO60602.fastaO60602858recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.Co-immunoprecipitataion Binding assay288278252017Pubchem_assay
PRRID_2039Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMembraneD0 domainO60602.fastaO60602858recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.Co-immunoprecipitataion Binding assay288278252017Pubchem_assay
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2055Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2055Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2056foreign DNA

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NANANANANaturalNAZBP1/DAIIntracellular associated Pattern recognition receptor (PRR)HumanCytoplasmNAQ9H171.fastaQ9H171429NANA290662552017Pubchem_assay
PRRID_2056foreign DNA

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NANANANANaturalNAZBP1/DAIIntracellular associated Pattern recognition receptor (PRR)HumanCytoplasmNAQ9H171.fastaQ9H171429NANA290662552017Pubchem_assay
PRRID_2057FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticanti- inflammatory activityToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2057FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticanti- inflammatory activityToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2063G-rich oligonucleotides

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BacteriaNANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNANAQ9NR97.fastaQ9NR971041NANA290662552017Pubchem_assay
PRRID_2063G-rich oligonucleotides

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BacteriaNANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNANAQ9NR97.fastaQ9NR971041NANA290662552017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2079Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2079Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2080Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2080Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2087Glycerol monomycolate (MMG, GroMM)

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2087Glycerol monomycolate (MMG, GroMM)

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2090glycomimetic

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NANANAAgonistSyntheticActivation of CLRs.DC-SIGNC type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)NANANAinhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017NA
PRRID_2090glycomimetic

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NANANAAgonistSyntheticActivation of CLRs.DC-SIGNC type Lectin (CTL/CLR)HumanPlasma membranecarbohydrate recognition domain (CRD)NANANAinhibit TLR immune response pathways while independently triggering inflammatory cytokines or can act in synergy with TLR pathways.Flow cytometry287764162017NA
PRRID_2093Guanosine analog Isatoribine

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NANANANANaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanairway and lung epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290283692017Pubchem_assay
PRRID_2093Guanosine analog Isatoribine

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NANANANANaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanairway and lung epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290283692017Pubchem_assay
PRRID_2095H. pylori-derived components

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humangastrointestinal epithelial cellsLRR and TIR domainO60603.fastaO60603784transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)qRT-PCR284278962017Pubchem_assay
PRRID_2095H. pylori-derived components

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humangastrointestinal epithelial cellsLRR and TIR domainO60603.fastaO60603784transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)qRT-PCR284278962017Pubchem_assay
PRRID_2096H. pylori-derived components

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangastrointestinal epithelial cellsLRR and TIR domainO00206.fastaO00206839transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)qRT-PCR284278962017Pubchem_assay
PRRID_2096H. pylori-derived components

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H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangastrointestinal epithelial cellsLRR and TIR domainO00206.fastaO00206839transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)qRT-PCR284278962017Pubchem_assay
PRRID_2101Heat shock protein

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Host (Endogenous) (others)NANANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNFκB-luciferase knock-in mice, humanLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2101Heat shock protein

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Host (Endogenous) (others)NANANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNFκB-luciferase knock-in mice, humanLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_2102Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Activate NF-KBNA280491422017Pubchem_assay
PRRID_2102Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Activate NF-KBNA280491422017Pubchem_assay
PRRID_2103Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Activate NF-KBNA280491422017Pubchem_assay
PRRID_2103Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Activate NF-KBNA280491422017Pubchem_assay
PRRID_2104Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 91 (CD91)Pattern recognition receptor (PRR)HumanNANAQ71UW0.fastaQ71UW092Activate NF-KBNA280491422017Pubchem_assay
PRRID_2104Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 91 (CD91)Pattern recognition receptor (PRR)HumanNANAQ71UW0.fastaQ71UW092Activate NF-KBNA280491422017Pubchem_assay
PRRID_2105Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 21 (CD21)Pattern recognition receptor (PRR)HumanNANAP08571.fastaP08571375Activate NF-KBNA280491422017Pubchem_assay
PRRID_2105Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 21 (CD21)Pattern recognition receptor (PRR)HumanNANAP08571.fastaP08571375Activate NF-KBNA280491422017Pubchem_assay
PRRID_2106Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 40 (CD40)Pattern recognition receptor (PRR)HumanNANAP29965.fastaP29965261Activate NF-KBNA280491422017Pubchem_assay
PRRID_2106Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 40 (CD40)Pattern recognition receptor (PRR)HumanNANAP29965.fastaP29965261Activate NF-KBNA280491422017Pubchem_assay
PRRID_2107Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanNANAP08571.fastaP08571375Activate NF-KBNA280491422017Pubchem_assay
PRRID_2107Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalplays a cytoprotective role in Alzeihmer Disease by suppression of Ab aggregation enhancing the clearance of Ab, restoring homeostasis, and inhibiting neuronal apoptosiscluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanNANAP08571.fastaP08571375Activate NF-KBNA280491422017Pubchem_assay
PRRID_2108Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanMonocyteLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375NANA289610192017Pubchem_assay
PRRID_2108Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanMonocyteLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375NANA289610192017Pubchem_assay
PRRID_2109Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2109Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289610192017Pubchem_assay
PRRID_2110Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA289610192017Pubchem_assay
PRRID_2110Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA289610192017Pubchem_assay
PRRID_2111Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.cluster of differentiation 91 (CD91)Pattern recognition receptor (PRR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ71UW0.fastaQ71UW092NANA289610192017Pubchem_assay
PRRID_2111Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-6 by human monocytes.cluster of differentiation 91 (CD91)Pattern recognition receptor (PRR)HumanMonocyteLeucine-rich Repeat (LRR) DomainQ71UW0.fastaQ71UW092NANA289610192017Pubchem_assay
PRRID_2112Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalnduce the maturation and activation of pDCs.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanpDCsLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375NANA289610192017Pubchem_assay
PRRID_2112Heat shock protein

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NANANADamage-associated molecular patterns (DAMPs)Naturalnduce the maturation and activation of pDCs.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanpDCsLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375NANA289610192017Pubchem_assay