The Total number of records shown on this page is 9. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_2972	Tanapoxvirus	TPV-delta66R-mMCP-1	DNA	Poxviridae	Deletion of 66R and insertion of MCP-1 gene	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Nude Foxn1 mice xenograft for HCT-116 (5.0E+6)	5.0E+6 pfu	NA	Reduction in tumor volume to 50mm after 36 days	Intratumoral	NA	Triggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8	NA	25887490
OV_2973	Tanapoxvirus	TPV-delta66R/flic	DNA	Poxviridae	Deletion of 66R and insertion of flic gene	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Nude Foxn1 mice xenograft for HCT-116 (5.0E+6)	5 × 10⁶ pfu	NA	Reduction in tumor volume to below 50mm after 36 days	Intratumoral	NA	Triggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8	NA	25887490
OV_2974	Tanapoxvirus	TPV-delta66R	DNA	Poxviridae	Deletion of 66R	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Nude Foxn1 mice xenograft for HCT-116 (5.0E+6)	5 × 10⁶ pfu	NA	Reduction in tumor volume to 50mm after 36 days	Intratumoral	NA	Triggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8	NA	25887490
OV_2975	Tanapoxvirus	TPV-delta2L	DNA	Poxviridae	Deletion of 2L gene	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Nude Foxn1 mice xenograft for HCT-116 (5.0E+6)	5 × 10⁶ pfu	NA	Reduction in tumor volume to below 50mm after 36 days	Intratumoral	NA	Triggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8	NA	25887490
OV_2976	Tanapoxvirus	TPV-delta2L/delta66R/flic	DNA	Poxviridae	Deletion of 66R, 2L and insertion of flic gene	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Nude Foxn1 mice xenograft for HCT-116 (5.0E+6)	5 × 10⁶ pfu	NA	Reduction in tumor volume to below 50mm after 36 days	Intratumoral	NA	Triggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8	NA	25887490
OV_5184	Tanapoxvirus	wild type	DNA	Poxviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 250 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5185	Tanapoxvirus	TPV-delta15L	DNA	Poxviridae	Deletion mutant for 15L gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Complete regression in tumor volume compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5186	Tanapoxvirus	TPV-delta66R	DNA	Poxviridae	Deletion mutant for tk 66ORF	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 150 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5187	Tanapoxvirus	TPV-delta15Ldelta66R	DNA	Poxviridae	Deletion mutant for 15L gene and tk 66R locus	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 200 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905