Detailed description page of Selected OV_ID


OV_2973 details
Primary information
OV_IDOV_2973
Virus Name Tanapoxvirus
StrainTPV-delta66R/flic
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDeletion of 66R and insertion of flic gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman colorectal cancer cell line
Cell lineHCT-116
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude Foxn1 mice xenograft for HCT-116 (5 × 10⁶)
In-vivo virus concentration5 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to below 50mm after 36 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectTriggers activation of Ipaf inflamosome, IL-beta, TNF-alpha, IL-6 and IL-8
Clinical trialNA
PMID25887490