The total number of records retrieved from this search are 9. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_2570	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	90% cell survival after 24 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2571	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	72.5% cell survival after 48 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2572	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	50.2% cell survival after 72 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2573	Adenovirus	SG600-IL-24	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	28.2% cell survival after 96 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2574	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	87.2% cell survival after 24 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2575	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	68% cell survival after 48 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2576	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	45% cell survival after 72 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2577	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	1000 cells	NA	MTT assay	10 MOI	25% cell survival after 96 hours	No	No	NA	No response	NA	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2578	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for HCCLM3 cell line	2.0E+8 pfu	NA	Significant reduction in tumor volume from the onset of tretament and till the end of 42 days and increase in median survival time	Intratumoral	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271