Detailed description page of Selected OV_ID


OV_2575 details
Primary information
OV_IDOV_2575
Virus Name Adenovirus
StrainSG600-IL-24+IFN
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B gene and insertion of IL-24 gene and addition of IN
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene and IFN gene
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHCCLM3
Concentration of cell line1000
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration10 MOI
In-vitro result68% cell survival after 48 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionCombined therapy increases STAT1, SOCS1 and apoptosis
Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF
Clinical trialNA
PMID22569271