Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 36. Click on ID to see further detail.
IDOV_606Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_609Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_612Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_615Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineKey Laboratory of Zoonosis, Jilin UniversityOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result10% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_898Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result2% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_899Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result20% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_900Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result50% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_901Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result20% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_902Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result40% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_903Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result80% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_904Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result60% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_905Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result80% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_906Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.01 pfu/cellIn-vitro result90% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_907Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result20% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_908Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result30% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_909Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result50% cancer cell killing after 24 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_910Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result50% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_911Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result60% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_912Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result100% cancer cell killing after 48 hourModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_913Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result60% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_914Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result80% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_915Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell linePC-3M-Pro4Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue stainingIn-vitro virus concentration0.1 pfu/cellIn-vitro result100% cancer cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_3724Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3M-LucConcentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3731Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell linePC-3M-LucConcentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration10 MOIIn-vitro result18% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_4909Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4910Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4911Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4912Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4913Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4914Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4915Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result30% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4916Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4917Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4918Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4919Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4920Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineJilin University chinaOrigin of cell lineHuman prostate cancer cell lineCell linePC-3MConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result15% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859