Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 133. Click on ID to see further detail.
IDOV_323Virus nameCanine parvovirusVirus strainCPV2.NS1Virus genome typeDNAVirus familyParoviridaeVirus genome modificationCPV genome expressing non-structural protein (NS1)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNCCS (National Centre for Cell Science, Pune, India)Origin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture mediumIn-vitro toxicityNAAssayLDH assayIn-vitro virus concentrationNAIn-vitro result9% cancer cell death at 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9Immunogenic effectNAClinical trialNAPMID26555166
IDOV_324Virus nameCanine parvovirusVirus strainCPV2.NS1Virus genome typeDNAVirus familyParoviridaeVirus genome modificationCPV genome expressing non-structural protein (NS1)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNCCS (National Centre for Cell Science, Pune, India)Origin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture mediumIn-vitro toxicityNAAssayLDH assayIn-vitro virus concentrationNAIn-vitro result18% cancer cell death at 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9Immunogenic effectNAClinical trialNAPMID26555166
IDOV_607Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineATCCOrigin of cell lineHuman cervical cancer cellCell lineHeLaConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result85% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_610Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineATCCOrigin of cell lineHuman cervical cancer cellCell lineHeLaConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result37% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_613Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineATCCOrigin of cell lineHuman cervical cancer cellCell lineHeLaConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result8% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_616Virus nameAdenovirusVirus strainCRAd-CCL21-IL15Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cellsVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeIL-15Source of cell lineATCCOrigin of cell lineHuman cervical cancer cellCell lineHeLaConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result5% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27380620
IDOV_1106Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration0.01MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_1107Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration0.1MOIIn-vitro result35% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_1108Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration1MOIIn-vitro result15% cell viablityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_1121Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration0.01MOIIn-vitro result50% cell viablityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_1122Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration0.1MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_1123Virus nameReovirusVirus strainwild typeVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineCervical cancer cell lineCell lineHeLaS3Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayFluoroscent mesure at 450nmIn-vitro virus concentration1MOIIn-vitro result25% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryPathway inducedApoptosis induction in cancer cell linesImmunogenic effectNAClinical trialNAPMID15958641
IDOV_3045Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3046Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3047Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3075Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3076Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3077Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3661Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result75% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3662Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result68% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3677Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3678Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3693Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result75% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3694Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix cancer cell lineCell lineHeLaConcentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3803Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result18% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3804Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3805Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result23% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3806Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result23% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3807Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result25% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3808Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result26% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3809Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result42% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3810Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result45% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3811Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result45% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3812Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3813Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3814Virus nameNewcastle disease virusVirus strainNDVstrain ADVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result62% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3815Virus nameNewcastle disease virusVirus strainNDVstrain 429Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result65% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3816Virus nameNewcastle disease virusVirus strainNDVstrain 27Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result65% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3817Virus nameNewcastle disease virusVirus strainNDVstrain 718Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result65% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3818Virus nameNewcastle disease virusVirus strainNDVstrain 49Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result68% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3819Virus nameNewcastle disease virusVirus strainNDVstrain 52Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result68% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3820Virus nameNewcastle disease virusVirus strainNDVstrain 329Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result75% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3821Virus nameNewcastle disease virusVirus strainNDVstrain 12Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result75% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3822Virus nameNewcastle disease virusVirus strainNDVstrain 53Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result79% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3823Virus nameNewcastle disease virusVirus strainNDVstrain 746Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result79% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3824Virus nameNewcastle disease virusVirus strainNDVstrain 389Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result82% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3825Virus nameNewcastle disease virusVirus strainNDVstrain 339Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result85% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3826Virus nameNewcastle disease virusVirus strainNDVstrain 922Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result90% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3827Virus nameNewcastle disease virusVirus strainNDVstrain 945Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result95% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3828Virus nameNewcastle disease virusVirus strainNDVstrain 753Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result100% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3829Virus nameNewcastle disease virusVirus strainNDVstrain 48Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result100% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3830Virus nameNewcastle disease virusVirus strainNDVstrain 465Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result100% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3908Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result42% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3909Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result23% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3910Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3911Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result67% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3912Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result64% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3913Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3914Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result29% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3915Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result24% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3916Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result24% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3917Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result25% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3918Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result21% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3919Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3920Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result32% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3921Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result24% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3922Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result21% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3923Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result56% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3924Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result51% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3925Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result58% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3926Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result51% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3927Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result52% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3928Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result47% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3929Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result51% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3930Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result47% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3931Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result46% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3932Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result28% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3933Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result20% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3934Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result25% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3935Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result19% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3936Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result17% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3937Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result17% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3938Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result61% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3939Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result61% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3940Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result41% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3995Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result42% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3996Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result24% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3997Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4007Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result70% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4008Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result65% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4009Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4019Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result30% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4020Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result25% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4021Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result24% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4031Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result25% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4032Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result20% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4033Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4043Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result30% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4044Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4045Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result20% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4055Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result58% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4056Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4057Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4067Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4068Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4069Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineInstitute of clinical and experimental lymphology, RussiaOrigin of cell lineHuman epitheloid cervix carcinomaCell lineHeLaConcentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4304Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix adenocarcinomaCell lineHeLaConcentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result66 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_4427Virus nameVesicular stomatitis virusVirus strainRdBVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing VSVG epitope, with no dletion in HI-loop, no addition of linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line1.2E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration21:1 particle to pfuIn-vitro result60% cell survival after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26430798
IDOV_4435Virus nameVesicular stomatitis virusVirus strainRdB-1L-VSVGVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing VSVG epitope, with no dletion in HI-loop, addition of single linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line1.2E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration24:1 particle to pfuIn-vitro result20% cell survival after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26430798
IDOV_4885Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4886Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result98% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4887Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result88% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4888Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result88% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4889Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result90% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4890Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4891Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result10% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4892Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result100% cell killing aftwr 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4893Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result80% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4894Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4895Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result10% cell viability after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_4896Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of IL21 and CCL21gene in virus genomeVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-21 and CCL21 geneSource of cell lineATCCOrigin of cell lineHuman cervix epithelial adenocarcinoma cell lineCell lineHeLaConcentration of cell line1 million cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result100% cell killing aftwr 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicitySlightly toxic to HeLa as measured by LDH assay In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivate proloferation of B-cell and Naive T-cellClinical trialNAPMID27157859
IDOV_5066Virus nameAvian orthoreovirusVirus strainARV-PB1Virus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line1.0E+3 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result50% cell viability after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28441762
IDOV_5196Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result100% cell viable after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5197Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result100% cell viable after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5198Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result80% cell viable after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5199Virus nameAdenovirusVirus strainTRAD-shLucVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for Luciferase gene knockoutVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result100% cell viable after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5200Virus nameAdenovirusVirus strainTRAD-shLucVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for Luciferase gene knockoutVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result100% cell viable after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5201Virus nameAdenovirusVirus strainTRAD-shLucVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for Luciferase gene knockoutVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result80% cell viable after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5202Virus nameAdenovirusVirus strainTRAD-shDICERVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for DICERVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result100% cell viable after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5203Virus nameAdenovirusVirus strainTRAD-shDICERVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for DICERVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result60% cell viable after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5204Virus nameAdenovirusVirus strainTRAD-shDICERVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having shorthairpin RNA for DICERVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineJCRB cell bankOrigin of cell lineHuman epithelia carcinoma cell lineCell lineHeLaConcentration of cell lineNAIn-vitro toxicityToxic to normal human cell line above 10 MOIAssayAlamar blue assayIn-vitro virus concentration2 MOIIn-vitro result10% cell viable after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27760834
IDOV_5621Virus nameNewcastle disease virusVirus strainNDV-MK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman cervical carcinoma cell lineCell lineHeLaConcentration of cell line80% confluencyIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration4 pfuIn-vitro result50% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectInduction of IFN-Gamma productionClinical trialNAPMIDUS7470426
IDOV_5841Virus nameNewcastle disease virusVirus strainNDV-PPMK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman cervical carcinoma cell lineCell lineHeLaConcentration of cell line80% confluencyIn-vitro toxicityNAAssayNAIn-vitro virus concentration4 pfuIn-vitro result50% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS8105578