Detailed description page of Selected OV_ID


OV_4892 details
Primary information
OV_IDOV_4892
Virus Name Adenovirus
Strainwild type
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAddition of IL21 gene in virus genome
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-21 gene
Source of cell lineATCC
Origin of cell lineHuman cervix epithelial adenocarcinoma cell line
Cell lineHeLa
Concentration of cell line1
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration50 MOI
In-vitro result100% cell killing aftwr 7 days
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicitySlightly toxic to HeLa as measured by LDH assay
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectActivate proloferation of B-cell and Naive T-cell
Clinical trialNA
PMID27157859