The total number of records retrieved from this search are 38. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_1447	Reovirus	ReoT3D	RNA	Reoviridae	None	Yes	No	No	NCI	Human NSCLC cell line	H226	NA	NA	XTT assay	Log10 pfu/cell	70% cell survived 48 hours after post infection	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1457	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death occurs at 0.543 CI value	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1463	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell death at CI value 0.344	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1469	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.218	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1475	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death occurs at 0.004 CI value	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1481	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell death at CI value 1 × 10⁴	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1487	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (77.79 +/- 25.08 micromolar, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 4 × 10⁶	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1493	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.615	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1499	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% death at CI value 0.297	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1505	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.145	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1511	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.558	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1517	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% death at CI value 0.057	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1523	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (14.71+/- 6.60, ratio is 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.013	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1529	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.112	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1535	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75 % cell death at CI 0.030	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1541	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.008	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1547	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.057	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1553	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.007	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1559	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (17.69+/- 10.16, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.001	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1565	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.081	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1571	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.043	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1577	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:20)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.023	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1583	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.027	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1589	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.006	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1595	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(28.46+/-14.13, 1:200)	No	NCI	Human NSCLC cell line	H226	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.001	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_4984	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	10 VP per cell	90% cell viability after 72 hours	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4985	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	No	Virus in combination with drugs pemetrexed 0.0026 mg/ml + cisplatin 0.0625	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	10 VP per cell	70% cell viability after 72 hours	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4986	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	No	Virus in combination with drugs pemetrexed 0.0026 mg/ml + carboplatin 0.0625	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	10 VP per cell	72% cell viability after 72 hours	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4994	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	1 VP per cell	100% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4995	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	10 VP per cell	90% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4996	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	100 VP per cell	40% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_4997	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	H226	1.0E+4 cells per well	NA	MTS assay	1000 VP per cell	20% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_5237	Parovirus	wild type	DNA	Paroviridae	None	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	10 VP per cell	10% cell viable	No	No	NA	No response	NA	NA	NA	NA	27783867
OV_5238	Parovirus	wild type	DNA	Paroviridae	None	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	100 VP per cell	2% cell viable	No	No	NA	No response	NA	NA	NA	NA	27783867
OV_5239	Parovirus	wild type	DNA	Paroviridae	None	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	1000 VP per cell	100% cell killing	No	No	NA	No response	NA	NA	NA	NA	27783867
OV_5249	Parovirus	Ad5/3VEGFE1-delta	DNA	Paroviridae	Deletion mutant for E1A gene and expressing VEGF gene	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	10 VP per cell	10% cell viable	No	No	NA	No response	NA	NA	NA	NA	27783867
OV_5250	Parovirus	Ad5/3VEGFE1-delta	DNA	Paroviridae	Deletion mutant for E1A gene and expressing VEGF gene	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	100 VP per cell	5 % cell viable	No	No	NA	No response	NA	NA	NA	NA	27783867
OV_5251	Parovirus	Ad5/3VEGFE1-delta	DNA	Paroviridae	Deletion mutant for E1A gene and expressing VEGF gene	Yes	No	No	ATCC	Human mesothelioma cell line	NCI-H226	5.0E+3 cells per well	NA	MTS assay	1000 VP per cell	100% cell killing	No	No	NA	No response	NA	NA	NA	NA	27783867