Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 54. Click on ID to see further detail.
IDOV_325Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result98% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_329Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration2.5 MOIIn-vitro result98% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_333Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration5 MOIIn-vitro result98% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_337Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result99% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_341Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration20 MOIIn-vitro result100% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_380Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.01 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_383Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_386Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_389Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration5 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_1607Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyHantaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineHuman Science Research Resource Bank, JapanOrigin of cell lineOral squamous cell lineCell lineH-1Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayLuminiscence measurementIn-vitro virus concentration0.01 MOIIn-vitro result30% cell are viable after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID19638980
IDOV_1620Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyHantaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineHuman Science Research Resource Bank, JapanOrigin of cell lineOral squamous cell lineCell lineH-1Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayLuminiscence measurementIn-vitro virus concentration0.01 MOIIn-vitro result25% cells are viable after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID19638980
IDOV_1633Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyHantaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineHuman Science Research Resource Bank, JapanOrigin of cell lineOral squamous cell lineCell lineH-1Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayLuminiscence measurementIn-vitro virus concentration1 MOIIn-vitro result25% cells are viable after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID19638980
IDOV_1646Virus nameSindbis virusVirus strainAR339Virus genome typeRNAVirus familyHantaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineHuman Science Research Resource Bank, JapanOrigin of cell lineOral squamous cell lineCell lineH-1Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayLuminiscence measurementIn-vitro virus concentration20 MOIIn-vitro result15% cells are viable after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID19638980
IDOV_2785Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2786Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.5 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2787Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2788Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration5 MOIIn-vitro resultModerate cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2789Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro resultAll cell was deadModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2790Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result90% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2791Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2792Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result80% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2793Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result80% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2794Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_3332Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result100% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3333Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3334Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result60% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3335Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result80% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3336Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result30% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3337Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result20% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3338Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result70% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3339Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result20% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3340Virus nameReovirusVirus strainRecombinant reovirus T1LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationMutant in L1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result100% cell killing after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3341Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result100% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3342Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3343Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result80% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3344Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result100% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3345Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result80% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3346Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result70% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3347Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration10 pfuIn-vitro result100% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3348Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration100 pfuIn-vitro result90% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3349Virus nameReovirusVirus strainRecombinant reovirus T3LVirus genome typeRNAVirus familyReoviridaeVirus genome modificationSubstitution mutant in T3 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayCell-titer-glo assayIn-vitro virus concentration1000 pfuIn-vitro result70% cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID28587298
IDOV_3631Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3632Virus nameMeasles virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result5% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3645Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3646Virus nameMumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell viability after day 6Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3659Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_3660Virus nameMeasles and mumps virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationMeasles virus in combination with mumps virusImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro resultComplete cell death after 6 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus in combination with induce apiptosis in cancer cellImmunogenic effectNAClinical trialNAPMID29485292
IDOV_4326Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman nonsmall cell lung cancerCell lineH-1299Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result96.3 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_4947Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4948Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4949Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4950Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineH-1299Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_5596Virus nameNewcastle disease virusVirus strainNDV-MK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung carcinoma cell lineCell lineH-1299Concentration of cell line80% confluencyIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration26 pfuIn-vitro result50% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectInduction of IFN-Gamma productionClinical trialNAPMIDUS7470426
IDOV_5832Virus nameNewcastle disease virusVirus strainNDV-PPMK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineH-1299Concentration of cell line80% confluencyIn-vitro toxicityNAAssayNAIn-vitro virus concentration26 pfuIn-vitro result50% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS8105578