The total number of records retrieved from this search are 12. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_393	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	50% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_394	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with SP600125 (100 μM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	35% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_395	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with 3-MA (5 mM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	38% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_396	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with z-YVAD- fmk (100 μM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	44% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_5100	Vaccinia virus	vvdd-tdTomato-hDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of human DAI	Yes	No	Virus expressing human DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.001 MOI	60% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5101	Vaccinia virus	vvdd-tdTomato-hDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of human DAI	Yes	No	Virus expressing human DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.01 MOI	30% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5102	Vaccinia virus	vvdd-tdTomato-hDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of human DAI	Yes	No	Virus expressing human DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.1 MOI	10% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5103	Vaccinia virus	vvdd-tdTomato-hDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of human DAI	Yes	No	Virus expressing human DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	1 MOI	100% cell killing	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5104	Vaccinia virus	vvdd-tdTomato-mDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of murine DAI	Yes	No	Virus expressing murine DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.001 MOI	80% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5105	Vaccinia virus	vvdd-tdTomato-mDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of murine DAI	Yes	No	Virus expressing murine DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.01 MOI	30% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5106	Vaccinia virus	vvdd-tdTomato-mDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of murine DAI	Yes	No	Virus expressing murine DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	0.1 MOI	10% cell viability	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058
OV_5107	Vaccinia virus	vvdd-tdTomato-mDAI	DNA	Poxviridae	Deletion of tk gene and vaccinia growth gene and addition of murine DAI	Yes	No	Virus expressing murine DAI gene	ATCC	Human melanoma cell line	A2058	1.0E+4 cells per well	NA	MTS assay	1 MOI	100% cell killing	No	No	NA	No response	NA	NA	Induction of Immunogenic gene such as T cell activation	NA	27626058