The total number of records retrieved from this search are 12. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
IDOV_393	Virus nameHerpes simplex virus	Virus strainICP10PK	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationDeletion mutant with R1 domain poorly functional in HSV-1	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman malignant melanoma cell lines	Cell lineA2058	Concentration of cell lineNA	In-vitro toxicityNA	AssayTrypan blue staining	In-vitro virus concentration1 MOI	In-vitro result50% cancer cell death at 48 hours after post infection	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduces JNK/c-Jun, autophagy and pyroptosis activation	Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	Clinical trialNA	PMID26602205
IDOV_394	Virus nameHerpes simplex virus	Virus strainICP10PK	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationDeletion mutant with R1 domain poorly functional in HSV-1	Virus aloneNo	Virus in combination with drug/radiationViral strain in combination with SP600125 (100 μM)	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman malignant melanoma cell lines	Cell lineA2058	Concentration of cell lineNA	In-vitro toxicityNA	AssayTrypan blue staining	In-vitro virus concentration1 MOI	In-vitro result35% cancer cell death at 48 hours after post infection	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduces JNK/c-Jun, autophagy and pyroptosis activation	Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	Clinical trialNA	PMID26602205
IDOV_395	Virus nameHerpes simplex virus	Virus strainICP10PK	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationDeletion mutant with R1 domain poorly functional in HSV-1	Virus aloneNo	Virus in combination with drug/radiationViral strain in combination with 3-MA (5 mM)	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman malignant melanoma cell lines	Cell lineA2058	Concentration of cell lineNA	In-vitro toxicityNA	AssayTrypan blue staining	In-vitro virus concentration1 MOI	In-vitro result38% cancer cell death at 48 hours after post infection	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduces JNK/c-Jun, autophagy and pyroptosis activation	Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	Clinical trialNA	PMID26602205
IDOV_396	Virus nameHerpes simplex virus	Virus strainICP10PK	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationDeletion mutant with R1 domain poorly functional in HSV-1	Virus aloneNo	Virus in combination with drug/radiationViral strain in combination with z-YVAD- fmk (100 μM)	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman malignant melanoma cell lines	Cell lineA2058	Concentration of cell lineNA	In-vitro toxicityNA	AssayTrypan blue staining	In-vitro virus concentration1 MOI	In-vitro result44% cancer cell death at 48 hours after post infection	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduces JNK/c-Jun, autophagy and pyroptosis activation	Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	Clinical trialNA	PMID26602205
IDOV_5100	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-hDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing human DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.001 MOI	In-vitro result60% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5101	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-hDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing human DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.01 MOI	In-vitro result30% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5102	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-hDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing human DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.1 MOI	In-vitro result10% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5103	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-hDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing human DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration1 MOI	In-vitro result100% cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5104	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-mDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing murine DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.001 MOI	In-vitro result80% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5105	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-mDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing murine DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.01 MOI	In-vitro result30% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5106	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-mDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing murine DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration0.1 MOI	In-vitro result10% cell viability	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058
IDOV_5107	Virus nameVaccinia virus	Virus strainvvdd-tdTomato-mDAI	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAI	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing murine DAI gene	Source of cell lineATCC	Origin of cell lineHuman melanoma cell line	Cell lineA2058	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTS assay	In-vitro virus concentration1 MOI	In-vitro result100% cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectInduction of Immunogenic gene such as T cell activation	Clinical trialNA	PMID27626058