The total number of records retrieved from this search are 41. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_608	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	96% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_611	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	1 MOI	94% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_614	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	10 MOI	92% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_617	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	50 MOI	90% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_842	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	NA	Epithelial ovarian carcinoma	SKOV3	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.01 MOI	35% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_843	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	OVCAR3	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.01 MOI	35% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_844	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	CaOV3	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.01 MOI	35% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_845	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2780	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.01 MOI	35% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_846	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2781	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.1 MOI	75% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_847	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2782	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.1 MOI	75% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_848	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2783	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.1 MOI	75% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_849	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2784	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	0.1 MOI	75% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_850	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2784	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	1 MOI	98% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_851	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2784	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	1 MOI	98% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_852	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2784	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	1 MOI	98% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_853	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant in ICP34.5 and ICPC6 gene	Yes	No	No	ATCC	Epithelial ovarian carcinoma	A2784	3.0E+3 cells per well	Minimal cytotoxic to mesothelial cells	Beta galacosidase colorimetric proliferation assay	1 MOI	98% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10770637
OV_4885	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	0.1 MOI	100% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4886	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	1 MOI	98% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4887	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	10 MOI	88% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4888	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	50 MOI	88% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4889	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 gene in virus genome	Yes	No	Virus expressing IL-21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	0.1 MOI	90% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4890	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 gene in virus genome	Yes	No	Virus expressing IL-21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	1 MOI	50% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4891	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 gene in virus genome	Yes	No	Virus expressing IL-21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	10 MOI	10% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4892	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 gene in virus genome	Yes	No	Virus expressing IL-21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	50 MOI	100% cell killing aftwr 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4893	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 and CCL21gene in virus genome	Yes	No	Virus expressing IL-21 and CCL21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	0.1 MOI	80% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4894	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 and CCL21gene in virus genome	Yes	No	Virus expressing IL-21 and CCL21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	1 MOI	20% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4895	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 and CCL21gene in virus genome	Yes	No	Virus expressing IL-21 and CCL21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	10 MOI	10% cell viability after 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_4896	Adenovirus	wild type	DNA	Adenoviridae	Addition of IL21 and CCL21gene in virus genome	Yes	No	Virus expressing IL-21 and CCL21 gene	ATCC	Human cervix epithelial adenocarcinoma cell line	HeLa	1 million cells per well	NA	MTT assay	50 MOI	100% cell killing aftwr 7 days	No	No	Slightly toxic to HeLa as measured by LDH assay	No response	NA	NA	Activate proloferation of B-cell and Naive T-cell	NA	27157859
OV_5071	Avian orthoreovirus	ARV-PB1	RNA	Reoviridae	None	Yes	No	No	ATCC	Human epithelial ovarian carcinoma	SKOV3	1.0E+3 cells per well	NA	Crystal violet staining	10 MOI	70% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28441762
OV_5196	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5197	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5198	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5199	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5200	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5201	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5202	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5203	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	60% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5204	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	10% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5671	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human renal epithelia cancer cell line	HRE	NA	NA	MTT assay	0.01 MOI	Complete cancer cell death	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5672	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human renal epithelia cancer cell line	HRE	NA	NA	MTT assay	1 MOI	Complete cancer cell death after day 8	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5850	Newcastle disease virus	NDV-PPMK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human neuroepithelia cancer cell line	SK-N-MC	80% confluency	NA	NA	20 pfu	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	US8105578