Welcome to IL-6Pred

Reference: Dhall A, Patiyal S, Sharma N, Usmani SS, Raghava GPS (2020) Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19 Briefings in Bioinformatics, dx.doi.org/10.1093/bib/bbaa259.

Several methods have been developed for the prediction of the antigenic regions for subunit vaccines designing. Interleukin-6 (IL-6) is a rapidly produced proinflammatory cytokine generated as an immune response in various infections and tissue injuries. Many studies show that high levels of IL-6 are related to a high risk of cancer and other disease conditions such as insulin resistance, asthma, coronary heart disease, advanced-stage cancer. The elevated level of IL-6 causes cytokine release syndrome(CRS) in severe COVID-19 patients. Thus, it is essential to check the subunit vaccine candidate provided to a COVID-19 patient must not be IL-6 inducing peptide. Based on our knowledge, we develop an in silico tool that allows the user to predict, scan, and map the IL-6 inducing/non-inducing peptides.