This webserver has been designed to help the scientific community in identification of potential disease causing antigens which can cause β-cell destruction in T1DM. This server predict T1DM causing peptides.
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This page provides help on different modules of server. Following are major modules in this server:
Predict: This module allows users to predict the T1DM causing peptide/epitope in a set of peptides or peptide library (virtual screening). User may submit large number of peptides and server will predict and rank them based on their potential to induce T1DM.
Design: It generate mutant of a query peptide and predict T1DM causing epitopes in mutants. This server allows users to identify minimum mutations required to increase its potency.
Protein Scan: This module allows user to identify regions in a protein, which are contributing in T1DM causing, which may be further removed or altered. The other way round, here users can also search a protein sequence to find out novel T1DM causing peptides.
Motif Scan: This module allows users to scan or map T1DM causing motifs in the query sequence, using MEME/MAST and MERCI programs.
BLAST Scan: This page allows users to search the query protein sequence against the database of known T1DM causing peptides using similarity-based search method, i.e. BLAST.
