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Details of CPPsite entry with Sequence CAYGRKKRRQRRR
Primary information
PEPTIDE SEQUENCECAYGRKKRRQRRR
CPPsite ID 2511, 2512, 2517, 2518, 2648,
PEPTIDE NAMEPTX-TAT-LP, PTX-C-TAT-LP, TAT-LP-PTX, T7/TAT-LP-PTX, TAT
CHIRALITYL, L, L, L, L
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear
SOURCESynthetic, Synthetic, Protein derived, Protein derived, Protein derived
CATEGORYCationic, Cationic, Cationic, Cationic, Cationic
SUB CELLULAR LOCALIZATIONCytoplasm, Cytoplasm, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Nucleus
N-TERMINAL MODIFICATIONConjugated with PTX via cysteine, Conjugated with PTX via cysteine, Cysteine addition, Conjugated with T7, Cysteine addition
C-TERMINAL MODIFICATIONConjugation with liposome-GSH, Conjugation with liposome-GSH, Conjugation with rhodamine LP, Conjugation with rhodamine LP, NA
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA
UPTAKE EFFICIENCYHigher uptake efficiency, Higher uptake efficiency, Lower uptake efficiency, Higher uptake efficiency, NA
PROPOSED UPTAKE MECHANISMEndocytosis, Macropinocytosis and caveolae mediated endocytois, Clathrin dependent pathway, Clathrin dependent pathway, Endocytosis
INVITRO/INVIVOIn vitro and in vivo, In vitro and in vivo, In vitro and in vivo, In vitro and in vivo, In vitro and in vivo
CELL LINEMurine B16F1 melanoma tumor cells, Murine B16F1 melanoma tumor cells, A549, A549, BCECs and C6s cells
In VIVO MODELB16F1 tumor-bearing C57 mice, B16F1 tumor-bearing C57 mice, BALB/c male athymic nude mice, BALB/c male athymic nude mice, Mice
CARGONanoparticle (PTX with liposome), GSH, Nanoparticle (PTX with liposome), GSH, Nanoparticle (Liposome), Nanoparticle (Liposome), Nanoparticle (Liposomes)
PMID25449709, 25449709, 25482610, 25482610, 22188312
PATENTUnknown, Unknown, Unknown, Unknown, Unknown
Tertiary Structure
(Technique)		2511 (PEPstrMOD), 2512 (PEPstrMOD), 2517 (PEPstrMOD), 2518 (PEPstrMOD), 2648 (PEPstrMOD),