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This page gives details of CPPsite entry with ID 2518
Primary information
CPPsite ID2518
PEPTIDE SEQUENCECAYGRKKRRQRRR
PEPTIDE NAMET7/TAT-LP-PTX
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm and Nucleus
N-TERMINAL MODIFICATIONConjugated with T7
C-TERMINAL MODIFICATIONConjugation with rhodamine LP
UPTAKE EFFICIENCYHigher uptake efficiency
PROPOSED UPTAKE MECHANISMClathrin dependent pathway
INVITRO/INVIVOIn vitro and in vivo
CELL LINEA549
In VIVO MODELBALB/c male athymic nude mice
CARGONanoparticle (Liposome)
PMID25482610
PATENTUnknown
LENGTH13
Secondary StructureCCSSHHHHHHHTC
SMILESN[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)