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This page gives details of CPPsite entry with ID 2512
Primary information
CPPsite ID2512
PEPTIDE SEQUENCECAYGRKKRRQRRR
PEPTIDE NAMEPTX-C-TAT-LP
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONConjugated with PTX via cysteine
C-TERMINAL MODIFICATIONConjugation with liposome-GSH
UPTAKE EFFICIENCYHigher uptake efficiency
PROPOSED UPTAKE MECHANISMMacropinocytosis and caveolae mediated endocytois
INVITRO/INVIVOIn vitro and in vivo
CELL LINEMurine B16F1 melanoma tumor cells
In VIVO MODELB16F1 tumor-bearing C57 mice
CARGONanoparticle (PTX with liposome), GSH
PMID25449709
PATENTUnknown
LENGTH13
Secondary StructureCCSSHHHHHHHTC
SMILESN[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)