Potential Vaccine Candidates

--------------------------------------------------------------------------------------------------------------------------------------------------------

This page provides list of potential vaccine candidate/epitopes in SARS-COV-2 proteins that can elicit both arms of immune system; adaptive immune system (memory B-cells and T-cells) and innate immune system (peptide-based vaccine-adjuvants). Firstly, experimentally epitopes were identified using IEDB. Here we used following prediction methods, LBtope B-cell epitopes; Propred1 for MHC Class I binders; and Propred for MHC Class II binders. In order to predict peptide-based vaccine adjuvants, we used VaxinPAD.

--------------------------------------------------------------------------------------------------------------------------------------------------------


S.No.Protein Potential Vaccine CandidateIEDB(T-cell) (#1)IEDB(B-cell) (#1)Bcell epitope (#2)Tcell epitope (#3)Vaccine Adjuvants (#4)MHC-I (#5)MHC-II (#6)
1Nucleocapsid PhosphoproteinLQLPQGTTLPKGFYAYesYesYesYesNoHLA-A2, HLA-A*0201, HLA-B*2705, HLA-B*51DRB1_0101, DRB1_0102, DRB1_0301, DRB1_0306, DRB1_0307, DRB1_0308, DRB1_0311, DRB1_0401, DRB1_0402
2Nucleocapsid PhosphoproteinVILLNKHIDAYKTFPPTEPKKDKKKKYesYesYesYesNoHLA-A3, HLA-A68.1, HLA-B*5301, HLA-B*5401, HLA-B*51DRB1_0817, DRB1_1101, DRB1_1102, DRB1_1104, DRB1_1106, DRB1_1107, DRB1_1114, DRB1_1120, DRB1_1328, DRB1_1327, DRB1_1323, DRB1_1322, DRB1_1321, DRB1_1311
3Membrane GlycoproteinEITVATSRTLSYesYesYesYesNoHLA-A1, HLA-B*3501, HLA-B*4403, HLA-B*5801DRB1_0421
4Nucleocapsid PhosphoproteinGKGQQQQGQTVYesYesYesYesNoHLA-A*0201, HLA-B*2702, HLA-B*2705, HLA-B*5201, HLA-B62, HLA-A*1101,HLA-A3,HLA-B*2705NA
5Membrane GlycoproteinSELVIGAVILRNoYesYesYesYesHLA-A1, HLA-A*3302, HLA-B14, HLA-A2.1, HLA-B*5101, HLA-B*5102, HLA-B*5103, HLA-B*3701, MHC-Db, MHC-KkDRB1_0101, DRB1_0102, DRB1_0301, DRB1_0305, DRB1_0306, DRB1_0307, DRB1_0308, DRB1_0309, DRB1_0311, DRB1_0402, DRB1_0421, DRB1_0802, DRB1_0804, DRB1_1101, DRB1_1102, DRB1_1104, DRB1_1106, DRB1_1107, DRB1_1120, DRB1_1121, DRB1_1128, DRB1_1301, DRB1_1302, DRB1_1305, DRB1_1311, DRB1_1322, DRB1_1327, DRB1_1328, DRB1_1501, DRB1_1506, DRB5_0101, DRB5_0105
6Enevelope ProteinALRLCAYCCNYesNoYesYesYesHLA-A1, HLA-B*2702, HLA-B*2705, HLA-B*4403, HLA-B*5101, HLA-B*5102, HLA-B*5103, HLA-B62, HLA-B*5801DRB1_0306, DRB1_0307, DRB1_0308, DRB1_0806
7ORF6HLVDFQVTIAEILLIIMRYesNoYesYesNoHLA-A*0205, HLA-A3, HLA-A2.1, HLA-B*3801, HLA-B*5102, HLA-B*5401, HLA-B62, HLA-B*0702, HLA-Cw*0401, MHC-Db, MHC-Kd, HLA-A*3302, HLA-B40, HLA-B*4403, HLA-B61, HLA-Cw*0301, HLA-Cw*0702, MHC-LdDRB1_0402, DRB1_0404, DRB1_0405, DRB1_0408, DRB1_0410, DRB1_0423, DRB1_1506, DRB1_1301, DRB1_1327, DRB1_1328, DRB5_0101, DRB5_0105
8Enevelope ProteinVFLLVTLAILTALRLCAYCCNIYesNoYesYesYesHLA-A2, HLA-A2.1, HLA-B*5103, HLA-B*5102, HLA-B*5101, HLA-B*5103, HLA-B62, MHC-KdDRB1_0311, DRB1_0410, DRB1_0423, DRB1_0806, DRB1_1101, DRB1_1102, DRB1_1106
9Membrane GlycoproteinNGTITVEELKKLLEQWNLVIGFLFLYesNoYesYesYesHLA-A24, HLA-A3, HLA-B*3701, HLA-B*4403, HLA-B*5101, HLA-B*5102, HLA-B*5103, HLA-B60, HLA-B*3902, HLA-B7, HLA-Cw*0401, MHC-Db revised, MHC-Dd, HLA-A2, HLA-A20, HLA-B*3902, HLA-B*0702, HLA-Cw*0301, HLA-A*0201, HLA-A*0205, HLA-A24, HLA-A2.1, HLA-B*2705, HLA-B62, MHC-Db, MHC-Kb, MHC-KdDRB1_0101, DRB1_0309, DRB1_0701, DRB1_0703, DRB1_1502, DRB5_0101, DRB5_0105
10Membrane GlycoproteinASFRLFARTRSMWSFNPETNILLNVPLHGTYesNoNoYesYesHLA-A*0201, HLA-A*0205, HLA-B*2702, HLA-Cw*0401, MHC-KbDRB1_1101, DRB1_1128, DRB1_0701, DRB1_0703
11Membrane GlycoproteinSRYRIGNYKLYesNoNoYesYesHLA-A24, HLA-B*2702, HLA-B*2705, HLA-B*3501, HLA-B*4403, HLA-B*5101, HLA-B*5301, HLA-B*5401, HLA-B*51, HLA-B*5801, HLA-B*0702, HLA-B8DRB1_0801, DRB1_0802
12ORF8RCSFYEDFLEYHDVRNoNoYesYesYesHLA-A24, HLA-A2.1, HLA-B*3701, HLA-B*3902, HLA-B40, HLA-B*4403, HLA-B*5301, HLA-B*5401, HLA-B60, HLA-B7, HLA-B*0702, HLA-Cw*0401, HLA-Cw*0702DRB1_0402, DRB1_1102, DRB1_1114, DRB1_1120, DRB1_1121, DRB1_1301, DRB1_1302, DRB1_1304, DRB1_1322, DRB1_1323, DRB1_1327, DRB1_1328
13ORF6IWNLDYIINLIIKNLSKSLTNoNoYesYesNoHLA-A*0201, HLA-A*0205, HLA-A24, HLA-A3, HLA-A*3101DRB1_0301, DRB1_0305, DRB1_0306, DRB1_0307, DRB1_0308, DRB1_0402, DRB1_0801
14Surface Glycoprotein SequenceSETKCTLKSFTVEKGIYQTSNFNoNoYesYesNoHLA-A1, HLA-A2, HLA-A*0201, HLA-A*1101, HLA-A24, HLA-A20 Cattle, HLA-A2.1, HLA-B40, HLA-B*4403, MHC-KkDRB1_0410, DRB1_1301, DRB1_1304, DRB1_1327, DRB1_1328
15ORF8MKFLVFLGIITTVAAFHQECSLQSCTQNoNoYesYesNoHLA-A2, HLA-A*0201, HLA-A*0205, HLA-A24, HLA-A20 Cattle, HLA-A2.1, HLA-B*3701, HLA-B*5102, HLA-B*5103, HLA-B*5201, HLA-B*5301, HLA-B*51, HLA-Cw*0401, HLA-Cw*0602, MHC-KdDRB1_0101, DRB1_0102, DRB1_0404, DRB1_0423, DRB1_1101, DRB1_1104, DRB1_1106, DRB1_1311, DRB1_1501, DRB1_1502, DRB1_1506
16ORF3aDGTTSPISENoNoYesYesNoHLA-B*3701, HLA-B*3801, HLA-B*5102, HLA-B*5103, HLA-B*5201NA
17ORF3aSKIITLKKRWQLALSKGVHFVCNLLLNoNoYesYesYesHLA-A2, HLA-A*0205, HLA-A*1101, HLA-A20 Cattle, HLA-A2.1, HLA-B*5801, HLA-B60NA
#1:IEDB   #2:LBtope   #3:CTLpred   #4: VaxinPAD    #5:ProPred-I   #6:ProPred

Vaccine Target Proteins:
                   
                                       

|| CoronaVir || India_MOHFW || WHO Advisory || Status || Diagnostics Tests || Genome || Patient Mangagement || Drug Design || Raghava's Group ||

Disclaimer and Copyright
This web site maintains information or links, collected and compiled from a wide range of sources (e.g., literature, databases, internet). Our aim is to facilitate the community to fight against COVID-19 but WITHOUT ANY WARRANTY OF RELIABILITY.