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Browsing by Modifications

This page lists the various Chemical modifications, N-terminal modifications as well as the C-terminal modifications that were incorportated in the anti-cancer peptides compiled in CancerPPD 2.0. For more information see User Guide.

Chemical Modifications

Modification Name Total Entries
None
 5288
Tle = L-tert-leucine
 3
Hyp = hydroxyproline; Thi = thienylalanine; (D)Pip—(D)-piperidine-2-carboxylic acid
 2
Hyp = hydroxyproline; Thi = thienylalanine; (L)Pip—(L)-piperidine-2-carboxylic acid
 1
Hyp = hydroxyproline; Thi = thienylalanine; (L)Pip—(L)-piperidine-2-carboxylic acid;(D)Pip—(D)-piperidine-2-carboxylic acid
 1
Hyp = hydroxyproline; Thi = thienylalanine; Acc = 1-aminocyclohexane-1-carboxylic acid
 2
Hyp = hydroxyproline; Thi = thienylalanine; Apc =1-aminocyclopentyl-1-carboxylic acid
 2
Not Available
 37
Proline residues in trans-configuration
 1
Aib = 2-Aminoisobutyric acid
 1
U = 2-Aminoisobutyric acid
 14
Z =4-aminopiperidine-4-carboxylic acid , U = 2-Aminoisobutyric acid
 1
AHMOD replaced by Cha(L-cyclohexylalanine); MDA = 2-methyl decanoic acid; Aib = a-aminoisobutyric acid;AMAE = 2-[(20-aminopropyl) methylamino] ethanol
 17
MDA = 2-methyl decanoic acid; AHMOD = 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid; Aib = a-aminoisobutyric acid;AMAE = 2-[(20-aminopropyl) methylamino] ethanol
 2
AHMOD replaced by Cha(L-cyclohexylalanine); MDA = 2-methyl decanoic acid; Aib = a-aminoisobutyric acid; AMAE = 2-[(20-aminopropyl) methylamino] ethanol
 1
O=Ornithine
 6
Ahx = Amino Hexanoic Acid
 3
X = OLeu
 3
Lauric acid conjugated to the 17th Lys-residue
 3
Octanoic acid acid conjugated to the 17th Lys-residue
 3
Palmitic acid conjugated to the 17th Lys-residue
 3
Dip = β-diphenylalanine
 6
X = Beta- Alanine
 1
N-Me-L = N-methyl-Lysine
 10
Jeffamine linker
 6
Cu2+ bound
 8
Z = C10H7CH2C(O), M, 4-(Trifluoromethyl)-D-phenylalanine
 1
nL = nor-Leu
 5
β-Ala
 5
Dansylglycine = fluorescent amino acid residue located in the side chain of lysine
 8
thermal oxidation between the thiol group of cysteine residue in the two 2-arm branched
 4
Branched amide bond in the branching point was formed by the primary amine of lysine.
 4
chiral N3,N5-bis[(l-phenylalaninyl-l-leucinyl) substituted aryl or heterocyclic Schiff base]pyridine
 6
carboxylic acid derivatives
 10
ester derivatives
 16
L-7dimethylallyl at Trp
 24
Aha= α-aminohenoic acid
 5
5-hydroxytryptophan
 4
β-3-benzothienyl-1-Ala
 1
Orn = Ornithine
 1
Dab = 2,4-diaminobutyric acid
 4
Dap = 2,3-diaminopropionic acid
 1
Agb = (S)-2-amino-4 guanidinobutyric acid
 1
Homo-arginine
 1
S5= (S)-2-(4-pentenyl)alanine
 20
R8=(R)-2-(7-octenyl)alanine; S5= (S)-2-(4-pentenyl)alanine
 8
X = 2,3-Diaminopropionic Acid , Z = norleucine
 4
Z = norleucine
 1
S5 = (S)-N-Fmoc-2-(4′-pentenyl)alanine
 36
Structure in scheme 2
 21
Structure in scheme 1
 5
3-me-P = (3R)-3-methylproline; AHMOD = (2S,4S)-2-Amino-4-methyl-6-hydroxy-8-oxodecanoic acid; Aib = 2-Aminoisobutyric acid; β-alanine; N-(2-Hydroxyethyl)-1,2-propanediamine
 2
conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG)
 2
Ahx = aminohexanoic acid; Lactam Bridge between K2 and E10 and between K13 and E22
 1
Ahx = aminohexanoic acid; Lactam Bridge between K2 and E10
 1
Ahx = aminohexanoic acid; Lactam Bridge between K6 and E18
 1
Substitution of hydroxyl group at Tyrosine with sulfonyl fluoride
 2
x = Norleucine
 3
U = SelenoCys
 12
Z= pyroglutamic acid
 2
beta-alanyl
 3
X = 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, U = 2-Aminoisobutyric acid
 9
X = 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, U = 2-Aminoisobutyric acid
 1
X = 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, Z = 4-aminopiperidine-4-carboxylic acid, U = 2-Aminoisobutyric acid
 1
U = 2-Aminoisobutyric acid (Aib)
 2
A5c = 1-aminocyclopentane carboxylic acid, A6c = 1-aminocyclohexane carboxylic acid
 16
A6c = 1-aminocyclohexane carboxylic acid, Oic = octahydroindolecarboxylic acid
 8
A6c = 1-aminocyclohexane carboxylic acid; Tic = tetrahydroisoquinolinecarboxylic acid
 8
A5c = 1-aminocyclopentane carboxylic acid
 16
A6c = 1-aminocyclohexane carboxylic acid, Dab = diaminobutyric acid
 8
A6c = 1-aminocyclohexane carboxylic acid, Orn = Ornithine
 8
A6c = 1-aminocyclohexane carboxylic acid
 20
Pcat = L-4R-aminoproline ; Phex = L-4R-hexyloxyproline
 4
Nal = beta-naphthylalanine
 18
Dip = diphenylalanine
 10
Dextran
 2
Pem= Pemetrexed
 6
Ade = 3-aminodecanoyl, Hleu =hydroxyleucyl, Hasn = hydoxyasparaginyl
 7
Aoc = 3-aminooctanoic acid ,Hyp = 4- hydroxyproline, Dhb = didehydrobutyrine, Hse = Homoserine
 3
Anthranilic acid
 1
A* = Cαα -dialkylated glycine (Aaa1,1 )
 63
A* = Cα -dialkylated glycine (Aaa2,2 )
 120
(2,2-di(4-[trifluoromethyl]benzyl)-3-amino-propionic acid)
 8
(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
 8
A*=Lanthionine bridge between Alanine
 6
AC6C = cyclohexyl-1-carboxylic acid
 9
O = Ornithine
 6
Aib = 1-amino-isobutyric acid
 6
Nal = 3-(1-naphthyl)alanine
 3
Dip = diphenylalanine, O=ornithine
 3
Aib = 1-amino-isobutyric acid ,Pac = Paclitaxel
 9
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
 24
Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ]
 8
-(CH2)6-CH=CH-(CH2)3; a biradical linker links L(3) and A(10)
 8
-(CH2)6-CH=CH-(CH2)3; a biradical linker links D(5) and S(10)
 1
-(CH2)6-CH=CH-(CH2)3; a biradical linker links R(8) and R(15)
 6
-(CH2)6-CH=CH-(CH2)3; a biradical linker links S(8) and H(15)
 1
-(CH2)6-CH=CH-(CH2)3; a biradical linker links R(4) and F(11)
 2
-(CH2)6-CH=CH-(CH2)3; a biradical linker links R(15) and Q(17)
 2
-(CH2)6-CH=CH-(CH2)3; a biradical linker links I(6) and Y(13)
 2
-(CH2)6-CH=CH-(CH2)3; a biradical linker links S(8) and Q(15)
 2
-(CH2)6-CH=CH-(CH2)3; a biradical linker links S(1) and I(8)
 2
-(CH2)2-CH=CH-(CH2)3; a biradical linker links S(1) and I(8)
 1
-(CH2)6-CH=CH-(CH2)3; a biradical linker links K(2) and L(9)
 2
-(CH2)6-CH=CH-(CH2)2; a biradical linker links K(2) and L(9)
 1
-(CH2)6-CH=CH-(CH2)3; a biradical linker links A(3) and S(10)
 3
-(CH2)6-CH=CH-(CH2)3; a biradical linker links P(4) and K(11)
 3
-(CH2)6-CH=CH-(CH2)3; a biradical linker links K(5) and A(12)
 3
-(CH2)6-CH=CH-(CH2)3; a biradical linker links V(6) and L(13)
 3
-(CH2)6-CH=CH-(CH2)3; a biradical linker links R(8) and Q(15)
 3
staple between Ala4 and d-Ala11
 1
aza-glycine; Me=Methylation
 1