| Detailed information |
|---|
| CancerLivER ID | 2524 |
| Biomarker | HIF1A |
| Biomarker Name/Symbol (given in Publication) | HIF1A |
| Biomolecule | RNAs |
| Subject | Human |
| Degree of Validity | Potential prognostic marker for disease free survival in HCC. The estimated 1-year and 5-year disease-free survival was significantly better in patients with low HIF1A expression in the non-malignant liver tissue when compared to those patients with high HIF1 expression (88.9% vs. 67.9% and 61.0% vs |
| Experimental Condition | HCC v/s non-tumor; predict recurrence of HCC in patients |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Upregulated in 17 HCC patients ( with fold change 2.14, ±0.93) and downregulated in 36 HCC patients (with fold change 0.75, ±0.26) in the HCC compared to corresponding non-malignant liver tissue |
| Level of significance | p < 0.001 |
| Source | Tissue |
| PMID | 20165955 |
| Type of Biomarker | Prognostic |
| Pathway | Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. |
| Cohort | Paired HCC and non-tumorous tissues from 53 HCC patients |
| Sensitivity | NA |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | HCC v/s non-tumor |
| Year of Publication | 2010 |
| Clinical trial | YES |
| NCT No# (Clinical trial) | NCT00866957,NCT02564614,NCT01801163 |