CancerLivER: Biomarker Card

Biomarker Card: Comprehensive information about a biomarker


Biomarker ID 2442
Detailed information
CancerLivER ID2442
Biomarker IQGAP3
Biomarker Name/Symbol (given in Publication)IQGAP3
BiomoleculeRNAs
SubjectHuman
Degree of ValidityPotential biomarker and therapeutic target for HCC and upregulated in highly invasive HCC than less-invasive HCC and validated on independent dataset
Experimental Conditionless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients
Cancer typeHepatocellular carcinoma
RegulationUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 2.24 )
Level of significance p < 0.01
SourceTissue
PMID19945130
Type of BiomarkerPrognostic
PathwayG-protein signaling RAC1 in cellular process and Signaling by Rho GTPases
Cohort188 HCC patients, 59 were selected randomly for test analyses (V0 [HCCs without vascular invasion] = 29 cases, V1 [HCCs with microvascular invasion] = 14 cases, and V2 [HCCs with macrovascular invasion] = 16 cases), and another 129 cases were evaluated for validation analyses (V0 = 67 cases, V1 = 33
SensitivityNA
SpecificityNA
AccuracyNA
AUCNA
Diseaseless (L) invasive HCC v/s highly (H) invasive HCC
Year of Publication2010
Clinical trialNO
Clinical trial (NCT Number)NA

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