| Detailed information |
|---|
| CancerLivER ID | 2267 |
| Biomarker | SPP1 |
| Biomarker Name/Symbol (given in Publication) | SPP1 or osteopontin |
| Biomolecule | RNAs and Protein |
| Subject | Human |
| Degree of Validity | SPP1 has good diagnostic value for metastatic HCC patients and validated on independent dataset |
| Experimental Condition | Metastatic HCC v/s Primary HCC |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Upregulated in PT than PN (with 3 fold change) |
| Level of significance | p < 0.01 |
| Source | Tissue |
| PMID | 12640447 |
| Type of Biomarker | Diagnostic |
| Pathway | Integrin Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. |
| Cohort | The 107 paired samples, including primary HCC, metastatic HCC and corresponding adjacent non-tumor liver tissue, were derived from 40 predominantly male and hepatitis B-positive Chinese patients with an average age of 50; 7 human hepatoma-derived cell lines (HuH1, HuH4, HuH7, MHCC97, SMMC7721, SK-H |
| Sensitivity | NA |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | Metastatic HCC v/s Primary HCC |
| Year of Publication | 2003 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |