| Detailed information |
|---|
| CancerLivER ID | 2179 |
| Biomarker | lamin B1 |
| Biomarker Name/Symbol (given in Publication) | lamin B1 |
| Biomolecule | Protein |
| Subject | Human |
| Degree of Validity | Lamin B1 is a clinically useful biomarker for early stages of HCC in tumor tissues and plasma; but not validated on independent dataset |
| Experimental Condition | Normal vs HCC; significantly associated with the increased number of tumor nodules , the size of tumors, and tumor stage |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Upregulated in liver cancer patients |
| Level of significance | p < 0.01 |
| Source | Plasma |
| PMID | 19522540 |
| Type of Biomarker | Diagnostic and Prognostic |
| Pathway | Functions in nuclear envelope lamina and possesses a transcriptional coregulatory activity having an important role in DNA replication, cellular aging, and stress responses |
| Cohort | cohort of 75 liver patients (39 HCCs, 20 cirrhosis, and 16 nondiseased subjects) |
| Sensitivity | 76% |
| Specificity | 82% |
| Accuracy | NA |
| AUC | NA |
| Disease | Human liver cancer |
| Year of Publication | 2010 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |