CancerLivER: Biomarker Card

Biomarker Card: Comprehensive information about a biomarker


Biomarker ID 2007
Detailed information
CancerLivER ID2007
Biomarker TOP2A
Biomarker Name/Symbol (given in Publication)TOP2A
BiomoleculeRNAs
SubjectHuman
Degree of ValidityPotential diagnostic marker for HCC and overexpressed in HCC v/s normal samples (validated in 3 datasets)
Experimental ConditionHCC v/s Normal
Cancer typeHepatocellular carcinoma
RegulationUpregulated (1.5 fold)
Level of significance p < 0.05
SourceTissue
PMID28977866
Type of BiomarkerDiagnostic
PathwayCancer Pathways include regulation of cellular protein metabolic process (GO:0032268), apoptotic process (GO:0006915), regulation of intracellular signal transduction (GO:1902531), cell cycle (GO:0007049), cell cycle phase transition (GO:0044770), pathways in cancer (Hsa05200), signaling pathways re
CohortIn GSE14520 dataset, 445 samples derived from HCC patients (225 tumor tissues and 220 non-cancerous tissues), for GSE6764, 45 samples ( 35 tumor tissues and 10 non- cancerous tissues). In addition, TCGA cohort have 84 HCC tumor samples and 42 paired adjcent non-cancer samples . Beside this, The norm
SensitivityNA
SpecificityNA
AccuracyNA
AUCNA
DiseaseHuman HCC
Year of Publication2017
Clinical trialNO
Clinical trial (NCT Number)NA

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