Browse result page of B3Pdb

The total number entries retrieved from this search are 335, scroll left/right for detailed information.

B3pdbID	PEPTIDE NAME	PEPTIDE SEQUENCE (1-letter)	PEPTIDE SEQUENCE (3-letter)	N-TERMINAL MODIFICATION	C-TERMINAL MODIFICATION	CHEMICAL MODIFICATION	PEPTIDE LENGTH	PEPTIDE CONFORMATION	PEPTIDE NATURE	SOURCE/ORIGIN OF PEPTIDE	SMILES	CELL LINE	In vitro CONCENTRATION	In vitro METHOD	In vitro RESULT	ANIMAL MODEL	In vivo CONCENTRATION	In vivo MODE OF DELIVERY	In vivo METHOD	In vivo RESULT	ACTION	TRANSPORT TYPE	SUBCELLULAR LOCALISATION	COMBINATION	PHYSICAL CONDITION	RESPONSE	RESULT	LABEL	PMID
b3pdb_0124	BVDO3	H-Dmt-D-RAbaG-NH11	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	1 mg/Kg	Intravenous	Hot water tail flick test	100% maximum possible effect after 120 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0125	BVDO3	H-Dmt-D-RAbaG-NH12	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.5 mg/Kg	Intravenous	Hot water tail flick test	10% maximum possible effect after 5 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0126	BVDO3	H-Dmt-D-RAbaG-NH13	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.5 mg/Kg	Intravenous	Hot water tail flick test	40% maximum possible effect after 15 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0127	BVDO3	H-Dmt-D-RAbaG-NH14	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.5 mg/Kg	Intravenous	Hot water tail flick test	60% maximum possible effect after 30 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0128	BVDO3	H-Dmt-D-RAbaG-NH15	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.5 mg/Kg	Intravenous	Hot water tail flick test	70% maximum possible effect after 60 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0129	BVDO3	H-Dmt-D-RAbaG-NH16	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.5 mg/Kg	Intravenous	Hot water tail flick test	100% maximum possible effect after 120 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0130	BVDO3	H-Dmt-D-RAbaG-NH17	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.1mg/Kg	Intravenous	Hot water tail flick test	30% maximum possible effect after 5 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0131	BVDO3	H-Dmt-D-RAbaG-NH18	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.1mg/Kg	Intravenous	Hot water tail flick test	30% maximum possible effect after 15 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0132	BVDO3	H-Dmt-D-RAbaG-NH19	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.1mg/Kg	Intravenous	Hot water tail flick test	50% maximum possible effect after 30 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0133	BVDO3	H-Dmt-D-RAbaG-NH20	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.1mg/Kg	Intravenous	Hot water tail flick test	50% maximum possible effect after 60 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0134	BVDO3	H-Dmt-D-RAbaG-NH21	H-Dmt-D-Arg-Aba-Gly-NH2	Methylation	Amidation	Addition of amiNAbenzoic acid at arginine	4	Tetrapeptide	Cationic	NA	NA	NA	NA	NA	NA	C57BL6 mice	0.1mg/Kg	Intravenous	Hot water tail flick test	50% maximum possible effect after 120 minutes	Cross BBB and shows morphine like action with analgesic effects	NA	NA	NA	NA	NA	NA	NA	22289619
b3pdb_0140	Met-Enkephalins	YGGFM	Tyr-Gly-Gly-Phe-Met-OH	NA	NA	NA	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	20 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 2 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0141	Leu-Enkephalins	YGGFL	Tyr-Gly-Gly-Phe-Leu-OH	NA	NA	NA	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	20 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 2 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0142	Fmoc-Met-Enkephalin	YGGFM	Tyr-Gly-Gly-Phe-Met-OH	NA	NA	Addition of Fmoc group towards N terminal	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	20 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 2 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0143	Fmoc-Leu-Enkephalins	YGGFL	Tyr-Gly-Gly-Phe-Leu-OH	NA	NA	Addition of Fmoc group towards N terminal	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	20 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 4 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0144	Fmoc-Leu-Enkephalins	YGGFL	Tyr-Gly-Gly-Phe-Leu-OH	NA	NA	Addition of Fmoc group towards N terminal	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	10 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 4 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0145	HOOC-(CH2)10-Leu-Enk	YGGFL	Tyr-Gly-Gly-Phe-Leu-OH	Addition of HOOC-(CH2)10 group to Fmoc	NA	Addition of HOOC-(CH2)10 group to Fmoc	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	10 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 3 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0146	Fmoc-Leu-Enkephalins	YGGFL	Tyr-Gly-Gly-Phe-Leu-OH	NA	NA	End to end joining of two Fmoc-Leu-Enkephalin	5	Linear	NA	NA	NA	NA	NA	NA	NA	ICR male mice	10 micromole/Kg	Intraperitoneal	Hot water tail flick test	Analgesic effect seen within 3.5 seconds	NA	NA	NA	NA	Alzheimer	NA	NA	NA	22778833
b3pdb_0211	Bacteriophage derive	SVHGV	SerValHisGlyVal	NA	NA	NA	5	Linear	NA	T7 Bacteiophage derived	NA	NA	NA	NA	NA	Male wistar mice	NA	NA	NA	NA	Can cross BBB as well as Blood CSF barrier	Transendocytosis	NA	NA	Alzheimer	NA	NA	NA	26411801
b3pdb_0214	Bacteriophage derive	LGSVS	LeuGlySerValSer	NA	NA	NA	5	Linear	NA	T7 Bacteiophage derived	NA	NA	NA	NA	NA	Male wistar mice	NA	NA	NA	NA	Can cross BBB as well as Blood CSF barrier	Transendocytosis	NA	NA	Alzheimer	NA	NA	NA	26411801
b3pdb_0216	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 5% diffuse into acceptor chamber after 2 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0217	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 5% diffuse into acceptor chamber after 2 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0218	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly7% diffuse into acceptor chamber after 4 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0219	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 5% diffuse into acceptor chamber after 4 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0220	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 15% diffuse into acceptor chamber after 8 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0221	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 7% diffuse into acceptor chamber after 8 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0222	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 20% diffuse into acceptor chamber after 24 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0223	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 15% diffuse into acceptor chamber after 24 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0224	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 2% diffuse into acceptor chamber after 2 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0225	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 2% diffuse into acceptor chamber after 2 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0226	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly5% diffuse into acceptor chamber after 4 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0227	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 3% diffuse into acceptor chamber after 4 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0228	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 12% diffuse into acceptor chamber after 8 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0229	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 5% diffuse into acceptor chamber after 8 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0230	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 25% diffuse into acceptor chamber after 24 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0231	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Cyclic	Cationic	Chemically synthesized	NA	BCEC cell line	0.3 microgram of peptide per ml	Competition assay	Nearly 15% diffuse into acceptor chamber after 24 hours	NA	NA	NA	NA	NA	NA	NA	NA	peptide combined with paclitaxel and Doxorubicin	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0232	NA	RGD	ArgGlyAsp	NA	NA	NA	3	Linear	Cationic	Chemically synthesized	NA	NA	NA	NA	NA	BALB/c mice xenograft for U87MG glioma cells	5mg/Kg	Intravenous	Fluoroscent measurement	Significant amount of drugsa delivered in brain tissue	Peptide can deliver drugs into brain tissue	NA	NA	Doxorubicin+paclitaxel in 5mg/Kg combination	Brain glioma therapy	NA	NA	NA	27143884
b3pdb_0261	Leu-Enkephalins	YGGFL	Tyr-Gly-Gly-Phe-Leu	NA	NA	NA	5	Pentapeptide	NA	Intestine and Brain	N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O	NA	NA	Adult Wistar SPF rats	NA	NA	NA	NA	NA	NA	morphine-like actions and addictive properties	NA	NA	NA	NA	NA	NA	NA	744146
b3pdb_0262	Met-Enkephalins	YGGFM	Tyr-Gly-Gly-Phe-Met	NA	NA	NA	5	Pentapeptide	NA	Intestine and Brain	N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCSC)C(=O)O	NA	NA	Adult Wistar SPF rats	NA	NA	NA	NA	NA	NA	morphine-like actions and addictive properties	NA	NA	NA	NA	NA	NA	NA	744146
b3pdb_0266	BW443C	YRGF(4-NO2)P(Nh2)	H-Tyr-D-Arg-Gly-Phe (4-NO2)-Pro-NH2	NA	NA	NA	5	Linear	NA	NA	N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O(NH2)	NA	NA	NA	NA	NA	NA	NA	NA	NA	Poorly passes BBB	NA	NA	NA	NA	NA	NA	NA	3349235
b3pdb_0300	5-FAM-PPL	PPL	NA	NA	NA	NA	3	Linear	NA	cerebral microvascular endothelial cell line (hCMEC/D3)	NA	NA	NA	in vitro model of the human BBB	NA	confocal microscopy and mass spectrometry	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	26716467
b3pdb_0351	cRGD-Exo	RGDYK	Arg-Gly-Asp-D-Tyr-Lys	NA	NA	NA	5	Linear	NA	NA	NA	NA	NA	MCAO mice model	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	29040874
b3pdb_0409	Thyrotropin releasin	Pyr-HP	Pyr-His-Pro	NA	NA	NA	3	Linear	NA	human,mouse,rat	O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3	NA	NA	NA	NA	NA	NA	Intracarotid injection	NA	NA	NA	Permeability	NA	NA	NA	Blood/brain ratio	132	Direct iodination	2413968
b3pdb_0410	Thyrotropin releasin	Pyr-HP	Pyr-His-Pro			NA	3	Linear	NA	human,mouse,rat	O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3	NA	NA	BUI method	NA	NA	NA	NA	NA	NA	NA	non saturable	NA	NA	NA	BUI	5.54%	H3/C14	3935272
b3pdb_0411	Thyrotropin releasin	Pyr-HP	Pyr-His-Pro			NA	3	Linear	NA	human,mouse,rat	O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3	NA	NA	BUI method	NA	NA	NA	NA	NA	NA	NA	non saturable	NA	NA	NA	BUI	3.42%	H3/C14	3935272
b3pdb_0412	Thyrotropin releasin	Pyr-HP	Pyr-His-Pro			NA	3	Linear	NA	human,mouse,rat	O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3	NA	NA	BUI method	NA	NA	NA	NA	NA	NA	NA	non saturable	NA	NA	NA	BUI	260%	H3/C14	3935272
b3pdb_0413	Thyrotropin releasin	Pyr-HP	Pyr-His-Pro			NA	3	Linear	NA	human,mouse,rat	O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3	NA	NA	BUI method	NA	NA	NA	NA	NA	NA	NA	non saturable	NA	NA	NA	BUI	3.39%	H3/C14	3935272
b3pdb_0519	[Met5] Enkephalin	YGGFM	Tyr-Gly-Gly-Phe-Met	NA	NA	NA	5	Linear	NA	mouse,rat	O=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSC	NA	NA	NA	NA	NA	NA	Intracarotid injection	NA	NA	NA	Permeability	NA	NA	NA	Blood/brain ratio	48	Direct iodination	2413968
b3pdb_0520	[Met5] Enkephalin	YGGFM	Tyr-Gly-Gly-Phe-Met	NA	NA	NA	5	Linear	NA	mouse,rat	O=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSC	NA	NA	BMEC	NA	NA	NA	NA	NA	NA	NA	Permeability	NA	NA	NA	Permeability coefficient	0.00002 cm/s	NA	9392847
b3pdb_0521	[Met5] Enkephalin	YGGFM	Tyr-Gly-Gly-Phe-Met	NA	NA	NA	5	Linear	NA	mouse,rat	O=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSC	NA	NA	BMEC	NA	NA	NA	NA	NA	NA	NA	Permeability	NA	NA	NA	Permeability coefficient	0.0000774 cm/s	NA	8371162, 8769896