Browse result page of B3Pdb

The total number entries retrieved from this search are 335, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0522[Leu5] EnkephalinYGGFLTyr-Gly-Gly-Phe-LeuNANANA5LinearNANAO=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CC(C)CNANANANANANAIntracarotid injectionNANA NA Permeability NA NA NA Blood/brain ratio 69 Direct iodination 2413968
b3pdb_0523Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.00106 mL/(g x min) Direct iodination 20347901
b3pdb_0524Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANANANANANAIntravenous NANA NA Permeability NA NA NA Initial distribution volume 0.04384 ml/g Direct iodination 20347901
b3pdb_0525Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAEfflux study ICUNANANANANANA NA saturable NA NA NA half life, brain 7.75 min Direct iodination 11482845
b3pdb_0526Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.089 min-1 Direct iodination 11482845
b3pdb_0527Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.047 min-1 Direct iodination 20347901
b3pdb_0528Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAEfflux study ICUNANANANANANA NA saturable NA NA NA half life, brain 14.7 min Direct iodination 20347901
b3pdb_0529Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 88.69% Direct iodination 20347901
b3pdb_0530Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 11.31% Direct iodination 20347901
b3pdb_0531Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAHPLCNANANANANANA NA NA NA NA NA half life, serum 7 min Direct iodination 20347901
b3pdb_0532Endomorphin-1YPWF-NH2Tyr-Pro-Trp-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5NANAHPLCNANANANANANA NA NA NA NA NA half life, brain 205 min Direct iodination 20347901
b3pdb_0533Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANANANANANAIntravenous NANA NA non saturable NA NA NA Unidirectional influx rate constant 0.00114 mL/(g x min) Direct iodination 20347901
b3pdb_0534Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANANANANANAIntravenous NANA NA non saturable NA NA NA Initial distribution volume 0.05224 ml/g Direct iodination 20347901
b3pdb_0535Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAEfflux study ICUNANANANANANA NA saturable NA NA NA half life, brain 10.18 min Direct iodination 11482845
b3pdb_0536Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.032 min-1 Direct iodination 20347901
b3pdb_0537Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAEfflux study ICUNANANANANANA NA saturable NA NA NA half life, brain 21.97 min Direct iodination 20347901
b3pdb_0538Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.068 min-1 Direct iodination 11482845
b3pdb_0539Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 96.36% Direct iodination 20347901
b3pdb_0540Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 3.64% Direct iodination 20347901
b3pdb_0541Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAHPLCNANANANANANA NA NA NA NA NA half life, brain 88 min Direct iodination 20347901
b3pdb_0542Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAHPLCNANANANANANA NA NA NA NA NA half life, brain 3.8 min H3/C14 22181340
b3pdb_0543Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAHPLCNANANANANANA NA NA NA NA NA half life, serum 4 min Direct iodination 20347901
b3pdb_0544Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAShake FlaskNANANANANANA NA NA NA NA NA Log P 0.457 H3/C14 22181340
b3pdb_0545Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANAShake FlaskNANANANANANA NA NA NA NA NA Log D 1.57 Direct iodination 12226841
b3pdb_0546Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANABMECNANANANANANA NA Permeability NA NA NA Permeability coefficient 0.00005317 cm/s Direct iodination 1,22,26,841
b3pdb_0547Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANABMECNANANANANANA NA Permeability NA NA NA Initial distribution Initial distribution Initial distribution Initial distribution Initial distribu 4.02 ml/g Direct iodination 12226841
b3pdb_0548Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANABMECNANANANANANA NA Permeability NA NA NA Unidirectonal influx rate constant 0.0347 mL/(g x min) Direct iodination 12226841
b3pdb_0549Endomorphin-2, EndomYPFF-NH2Tyr-Pro-Phe-Phe-NH2NANANA4LinearNANAO=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4NANABMECNANANANANANA NA non saturable NA NA NA Permeability coefficientendoth 0.00000784 cm/s H3/C14 22181340
b3pdb_0550β-Casomorphin-5YPFPGTyr-Pro-Phe-Pro-GlyNANANA5LinearNAhuman,bovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C1NCCC1NANAEfflux study ICUNANANANANANA NA saturable NA NA NA half life, brain 22.4 min Direct iodination 8105102
b3pdb_0551β-Casomorphin-5YPFPGTyr-Pro-Phe-Pro-GlyNANANA5LinearNAhuman,bovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C1NCCC1NANAEfflux study ICUNANANANANANA NA saturable NA NA NA Brain elemination rate constant 0.031 min-1 Direct iodination 8105102
b3pdb_0552Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Unidirectional flux rate constant 0.00234 mL/(g x min) Direct iodination 8786534
b3pdb_0553Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA Initial distribution vaolume 0.0189 ml/g Direct iodination 8786534
b3pdb_0554Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANANANANANAin situ brain perfusionNANA NA Permeability NA NA NA permiability constant 0.00000039 cm/s Direct iodination 8786534
b3pdb_0555Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANAHPLCNANANANANANA NA NA NA NA NA % injected dose 0.089 %/g NA 8371162
b3pdb_0556Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANAHPLCNANANANANANA NA NA NA NA NA half life, brain 173 min Direct iodination 8786534
b3pdb_0557Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANAHPLCNANANANANANA NA NA NA NA NA half life, brain 112 min Direct iodination 8389867
b3pdb_0558Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANAShake FlaskNANANANANANA NA NA NA NA NA Log P -0.7 Direct iodination 8786534
b3pdb_0559Melanocyte-stimulatiPLG-NH2Pro-Leu-Gly-NH2NANANA3LinearNAhuman,bovineCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1NANABMECNANANANANANA NA saturable NA NA NA Permeability coefficient 0.0000916667 cm/s NA 8769896, 8786534
b3pdb_0560Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Unidirectional flux rate constant 0.00146 mL/(g x min) H3/C14 8769896
b3pdb_0561Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANANANANANAin situ brain perfusionNANA NA saturable NA NA NA Initial distribution vaolume 0.036 ml/g H3/C14 8769896
b3pdb_0562Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 87.25% H3/C14 8769896
b3pdb_0563Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANACapillary depletionNANANANANANA NA NA NA NA NA % capillary 12.75% H3/C14 8769896
b3pdb_0564Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANAHPLCNANANANANANA NA NA NA NA NA % injected dose 0.064 %/g NA 8371162
b3pdb_0565Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANAShake FlaskNANANANANANA NA NA NA NA NA Log P -0.48 Direct iodination 11454951
b3pdb_0566Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANAShake FlaskNANANANANANA NA NA NA NA NA Log P -1.12 H3/C14 8769896
b3pdb_0567Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANABMECNANANANANANA NA Permeability NA NA NA Permeability coefficient 0.00008207 cm/s NA 8667199
b3pdb_0568Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANABMECNANANANANANA NA Permeability NA NA NA Permeability coefficient 0.0000820667 cm/s NA 9392847, 8371162
b3pdb_0569Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNANANA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANANANANANAIn situ perfusion (single time)NANA NA Permeability NA NA NA Unidirectonal influx rate constant 0.00226 mL/(g x min) H3/C14 8769896
b3pdb_0570Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANANANANANAIn situ perfusion (single time)NANA NA saturable NA NA NA in vitro influx rate 3.54% Direct iodination 11337097
b3pdb_0571Tyr-Melanocyte-stimuYPLGTyr-Pro-Leu-GlyNA4LinearNAbovineO=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2NANACapillary deplition in situ b pNANANANANANA NA saturable NA NA NA Gas constant pellet 1.35% Direct iodination 11337097