Browse result page of B3Pdb

The total number entries retrieved from this search are 318, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_0093BVDO2DmtNmeAFS-NH15H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test80% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0094BVDO2DmtNmeAFS-NH16H-Dmt-Nme-D-Ala-Phe-Ser-NH2MethylationAmidationNA4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0095BVDO3Dmt-N-Me-D-AAbaG-NH2Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0096BVDO3Dmt-N-Me-D-AAbaG-NH3Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0097BVDO3Dmt-N-Me-D-AAbaG-NH4Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0098BVDO3Dmt-N-Me-D-AAbaG-NH5Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0099BVDO3Dmt-N-Me-D-AAbaG-NH6Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0100BVDO3Dmt-N-Me-D-AAbaG-NH7Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0101BVDO3Dmt-N-Me-D-AAbaG-NH8Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0102BVDO3Dmt-N-Me-D-AAbaG-NH9Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0103BVDO3Dmt-N-Me-D-AAbaG-NH10Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0104BVDO3Dmt-N-Me-D-AAbaG-NH11Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0105BVDO3Dmt-N-Me-D-AAbaG-NH12Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0106BVDO3Dmt-N-Me-D-AAbaG-NH13Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0107BVDO3Dmt-N-Me-D-AAbaG-NH14Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0108BVDO3Dmt-N-Me-D-AAbaG-NH15Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0109BVDO3Dmt-N-Me-D-AAbaG-NH16Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0110BVDO3Dmt-N-Me-D-AAbaG-NH17Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0111BVDO3Dmt-N-Me-D-AAbaG-NH18Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0112BVDO3Dmt-N-Me-D-AAbaG-NH19Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0113BVDO3Dmt-N-Me-D-AAbaG-NH20Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0114BVDO3Dmt-N-Me-D-AAbaG-NH21Dmt-N-Me-D-Ala-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at alanine4TetrapeptideCationicNANANANANANAC57BL6 mice0.25mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0115BVDO3H-Dmt-D-RAbaG-NH2H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0116BVDO3H-Dmt-D-RAbaG-NH3H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0117BVDO3H-Dmt-D-RAbaG-NH4H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0118BVDO3H-Dmt-D-RAbaG-NH5H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0119BVDO3H-Dmt-D-RAbaG-NH6H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice4 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0120BVDO3H-Dmt-D-RAbaG-NH7H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0121BVDO3H-Dmt-D-RAbaG-NH8H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test60% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0122BVDO3H-Dmt-D-RAbaG-NH9H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test90% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0123BVDO3H-Dmt-D-RAbaG-NH10H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0124BVDO3H-Dmt-D-RAbaG-NH11H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice1 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0125BVDO3H-Dmt-D-RAbaG-NH12H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test10% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0126BVDO3H-Dmt-D-RAbaG-NH13H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test40% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0127BVDO3H-Dmt-D-RAbaG-NH14H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test60% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0128BVDO3H-Dmt-D-RAbaG-NH15H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test70% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0129BVDO3H-Dmt-D-RAbaG-NH16H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.5 mg/KgIntravenous Hot water tail flick test100% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0130BVDO3H-Dmt-D-RAbaG-NH17H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.1mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 5 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0131BVDO3H-Dmt-D-RAbaG-NH18H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.1mg/KgIntravenous Hot water tail flick test30% maximum possible effect after 15 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0132BVDO3H-Dmt-D-RAbaG-NH19H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.1mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 30 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0133BVDO3H-Dmt-D-RAbaG-NH20H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.1mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 60 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0134BVDO3H-Dmt-D-RAbaG-NH21H-Dmt-D-Arg-Aba-Gly-NH2MethylationAmidationAddition of amiNAbenzoic acid at arginine4TetrapeptideCationicNANANANANANAC57BL6 mice0.1mg/KgIntravenous Hot water tail flick test50% maximum possible effect after 120 minutes Cross BBB and shows morphine like action with analgesic effects NA NA NA NA NA NA NA 22289619
b3pdb_0136G23HLNILSTLWKYRHisLeuAsnIleLeuSerThrLeuTrpLysTyrArgNANANA12LinearNAPhage display of prion proteinsNANANANANABALB/c miceNAIntravenous Radioimaging0.052 + 0.019 of fluoroscent measured in btain tissue after 4 hours NA Transcytosis as well as BBB penetration NA NA NA NA NA NA 22536790
b3pdb_0137G23HLNILSTLWKYRHisLeuAsnIleLeuSerThrLeuTrpLysTyrArgNANANA12LinearNAPhage display of prion proteinsNANANANANABALB/c miceNAIntravenous Radioimaging0.047 + 0.031 of fluoroscent measured in btain tissue after 24 hours NA Transcytosis as well as BBB penetration NA NA NA NA NA NA 22536790
b3pdb_0138Scr-G23KISHLLNYRTWLLysIleSerHisLeuLeuAsnTyrArgThrTrpLeuNANANA12LinearNAPhage display of prion proteinsNANANANANABALB/c miceNAIntravenous Radioimaging0.013 + 0.006 of fluoroscent measured in btain tissue after 4 hours NA Transcytosis as well as BBB penetration NA NA NA NA NA NA 22536790
b3pdb_0139Scr-G23KISHLLNYRTWLLysIleSerHisLeuLeuAsnTyrArgThrTrpLeuNANANA12LinearNAPhage display of prion proteinsNANANANANABALB/c miceNAIntravenous Radioimaging0.008 + 0.002 of fluoroscent measured in btain tissue after 24 hours NA Transcytosis as well as BBB penetration NA NA NA NA NA NA 22536790
b3pdb_0151MPEG-PCL-TatNANAAddition of MPEG and ploygalactolactoneNAAddition of MPEG and PCLNALinearNAChemically synthesizedNANANANANAAdult Sprague-Dawley rats100 microliterIntravenous Fluoroscent screening by FITC labbled peptide maass in brain tissue0.5% fluoroscence observed in brain tissue NA NA NA NA NA NA NA NA 23992922
b3pdb_0175Angiopep-2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrNANAConjugated with Tratuzumab19LinearNANANANANANANAMale Crl:Cd-1 nude mice10mg/KgIntravenous Fluoroscent screening by FITC labbled peptide maass in brain tissueSignificant fluoroscdnt observed in brain tissue NA NA NA NA Breast cancer metastasis NA NA NA 25492620
b3pdb_0176Angiopep-2TFFYGGSRGKRNNFKTEEYThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyrNANAConjugated with Tratuzumab19LinearNANANANANANANAMale mice xenograft for BT 474 cell line intracerebrally6 ml/kgIntravenous In situ brain perfusion assay10 time increase of Mab as compared to control in brain tissue NA NA NA NA Breast cancer metastasis NA NA NA 25492620
b3pdb_0232NARGDArgGlyAspNANANA3LinearCationicChemically synthesizedNANANANANABALB/c mice xenograft for U87MG glioma cells5mg/KgIntravenous Fluoroscent measurementSignificant amount of drugsa delivered in brain tissue Peptide can deliver drugs into brain tissue NA NA Doxorubicin+paclitaxel in 5mg/Kg combination Brain glioma therapy NA NA NA 27143884