Detailed description page of B3Pdb
This page provides detail information of Selected ID b3pdb_0176 |
| Primary information | |
|---|---|
| B3PDB ID | b3pdb_0176 |
| Peptide Name | Angiopep-2 |
| PEPTIDE SEQUENCE (1-letter) | TFFYGGSRGKRNNFKTEEY |
| PEPTIDE SEQUENCE (3-letter) | ThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGluTyr |
| N-terminal modification | NA |
| C-terminal modification | NA |
| Chemical modification | Conjugated with Tratuzumab |
| Peptide Length | 19 |
| Conformation | Linear |
| Peptide Nature | NA |
| Source/Origin of peptide | NA |
| SMILES | NA |
| Cell Line | NA |
| In vitro CONCENTRATION | NA |
| In vitro METHOD | NA |
| In vitro RESULT | NA |
| ANIMAL MODEL | Male mice xenograft for BT 474 cell line intracerebrally |
| In vivo CONCENTRATION | 6 ml/kg |
| In vivo MODE OF DELIVERY | Intravenous |
| In vivo METHOD | In situ brain perfusion assay |
| In vivo RESULT | 10 time increase of Mab as compared to control in brain tissue |
| ACTION | NA |
| TRANSPORT TYPE | NA |
| SUBCELLULAR LOCALISATION | NA |
| COMBINATION | NA |
| PHYSICAL CONDITION | Breast cancer metastasis |
| RESPONSE | NA |
| RESULT | NA |
| LABEL | NA |
| PMID | 25492620 |