Target Organism : Brucella S2 vaccine strain

Total records found: 5

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_1884	40451960	2025	Screening and characterization of nucleic acid aptamers targeting Brucella surface antigens: identification and analysis of their corresponding binding sites	WS-6	GCTGCAATACTCATGGACAGCACGGCACGGGCTGTCGATCTCGAGGGAAACGGCACATGTGTCTGGAGTACGACCCTGAA	80	N/A	ssDNA	Brucella S2 vaccine strain	Outer membrane protein BamA (β-barrel assembly machinery A)	Identify aptamers against Brucella and conjugate them to liposomes for selective recognition and significantly reduced bacterial invasion of host cells.	WS-6 significantly reduced Brucella invasion, as evidenced by a decrease in qPCR Ct from 22.34 to 20.64 (P < 0.05), confirming a reduced intracellular bacterial load.	13	Indirect Enzyme-Linked Aptamer Assay (i-ELAA)	16.23 ± 5.84 nM	Therapeutics	Whole Cell-SELEX	5'-Biotinylated and 5'-FAM Labeled	N/A	The aptamer demonstrated stable binding to the Brucella S2 vaccine across a temperature range of 16–50°C, with optimal binding observed between 16°C and 50°C and under neutral conditions (pH 7.6) in 2h.	Best Candidate	N/A	N/A
ABdb_1885	40451960	2025	Screening and characterization of nucleic acid aptamers targeting Brucella surface antigens: identification and analysis of their corresponding binding sites	WS-26	GCTGCAATACTCATGGACAGCGGAACGCTGTCTCCTCATTCAATCTAGGAGTCTGCGTGAGTCTGGAGTACGACCCTGAA	80	N/A	ssDNA	Brucella S2 vaccine strain	Whole cell	Binds BamA β-barrel assembly protein → blocks/inhibits bacterial invasion into host cells.	N/A	13	Indirect Enzyme-Linked Aptamer Assay (i-ELAA)	20.33 ± 8.12 nM	Therapeutics	Whole Cell-SELEX	5'-Biotinylated and 5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1886	40451960	2025	Screening and characterization of nucleic acid aptamers targeting Brucella surface antigens: identification and analysis of their corresponding binding sites	WS-17	GCTGCAATACTCATGGACAGGACAACGTCCTGTACCAGCGCTACGCCAGATCAGTTTTAGGTCTGGAGTACGACCCTGAA	80	N/A	ssDNA	Brucella S2 vaccine strain	Whole cell	Binds BamA β-barrel assembly protein → blocks/inhibits bacterial invasion into host cells.	N/A	13	Indirect Enzyme-Linked Aptamer Assay (i-ELAA)	17.11 ± 6.35 nM	Therapeutics	Whole Cell-SELEX	5'-Biotinylated and 5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1887	40451960	2025	Screening and characterization of nucleic acid aptamers targeting Brucella surface antigens: identification and analysis of their corresponding binding sites	WS-32	GCTGCAATACTCATGGACAGGGGACTCAGGTCCCCGGGAGCGCAATGGTGGGGTTTTAATGTCTGGAGTACGACCCTGAA	80	N/A	ssDNA	Brucella S2 vaccine strain	Whole cell	Binds BamA β-barrel assembly protein → blocks/inhibits bacterial invasion into host cells.	N/A	13	Indirect Enzyme-Linked Aptamer Assay (i-ELAA)	13.08 ± 2.97 nM	Therapeutics	Whole Cell-SELEX	5'-Biotinylated and 5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1888	40451960	2025	Screening and characterization of nucleic acid aptamers targeting Brucella surface antigens: identification and analysis of their corresponding binding sites	WS-44	GCTGCAATACTCATGGACAGGGACCTGTCCCTGGCCTCTTAGGGTAAAATTTTGCCACAAGTCTGGAGTACGACCCTGAA	80	N/A	ssDNA	Brucella S2 vaccine strain	Whole cell	Binds BamA β-barrel assembly protein → blocks/inhibits bacterial invasion into host cells.	N/A	13	Indirect Enzyme-Linked Aptamer Assay (i-ELAA)	15.03 ± 4.2 nM	Therapeutics	Whole Cell-SELEX	5'-Biotinylated and 5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A